逍遥散加减方治疗女性肝郁血虚型慢性便秘的临床疗效观察

发布时间：2018-01-03 17:36

本文关键词：逍遥散加减方治疗女性肝郁血虚型慢性便秘的临床疗效观察　出处：《南京中医药大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:观察逍遥散加减方治疗女性肝郁血虚型慢性便秘的临床疗效及安全性,为临床治疗女性慢性便秘提供参考。方法:采用随机分组的方法,将符合纳入标准的60例女性肝郁血虚型慢性便秘患者分为治疗组30例,予逍遥散加减方,对照组30例采用聚乙二醇4000散剂(福松)治疗,疗程为8周。以每周完全自发排便(SCBM)≥3次的患者比例,慢性便秘主要症状积分、中医证候疗效为评定指标,并在疗程结束后进行随访4周以观察远期疗效,结果采用SPSS 22.0统计学软件处理并分析。结果:1.每周SCBM≥3次:治疗第4周治疗组和对照组的SCBM≥3次患者比例分别为30%和26.7%;第8周两组SCBM≥3次患者比例为治疗组36.7%,对照组36.6%,均无统计学差异(P0.05)。2.主要症状:两组患者的症状经治疗均有不同程度减轻,但在排便费力、排便频率、粪便性状上两组无明显统计学差异(P0.05);而治疗组较对照组在排便不尽感方面改善明显(P0.05),治疗组主要症状总积分与对照组比较有统计学差异(P0.05)。3.中医证候:治疗组与对照组总有效率分别为90%和76.7%,治疗组在中医证候方面改善效果显著(P0.05)。4.远期疗效:疗程结束后半个月,治疗组与对照组每周SCBM≥3次的患者比例、两组便秘主症总评分比较无统计学差异(P0.05),症状改善情况相似,治疗后第一个月,治疗组患者每周SCBM≥3次的比例为30%,对照组比例为10%,两组具有统计学差异(P0.05);主症总评分对比,治疗组在疗效维持上优于对照组(P0.05)。整个治疗过程中,两组患者均未出现不良反应。结论:逍遥散加减方对于改善女性肝郁血虚型慢性便秘临床症状效果明显,尤其在中医证候和远期疗效方面更具优势。
[Abstract]:Objective: To observe the clinical efficacy and safety of Xiaoyaosan female liver blood deficiency type chronic constipation, provide the reference for the clinical treatment of women with chronic constipation. Methods: a randomized method, will meet the inclusion criteria of 60 cases of female Ganyu deficiency type chronic constipation patients were divided into treatment group of 30 patients treated with modified Xiaoyaosan, the control group of 30 patients with macrogol 4000 powder (Forlax) treatment, treatment for 8 weeks. The weekly complete spontaneous bowel movements (SCBM) more than 3 times the proportion of patients, the main symptoms of chronic constipation score, TCM efficacy as evaluation index, and in the 4 weeks after the end of treatment were followed up to observe the long-term effect, the SPSS 22 statistical software processing and analysis. Results: 3 times a week 1. SCBM higher than that after fourth weeks of treatment, the treatment group and the control group of SCBM is more than 3 times the proportion of patients were 30% and 26.7%; the proportion of eighth weeks and two in group SCBM is more than 3 times the patients into the treatment group 36.7%, 36.6% in the control group, there was no significant difference (P0.05.2.) the main symptoms: two groups of patients after treatment, symptoms were relieved in different degree, but in the defecation, defecation frequency, stool on the two groups had no significant difference (P0.05); the treatment group improved significantly than the control group in the endless sense (P0.05), the treatment group total score of main symptoms compared with the control group there were significant differences (P0.05).3. TCM: treatment group and control group, the total effective rate was 90% and 76.7% in the treatment group, TCM syndrome and improve the effect of long term effects of.4. (P0.05): half a month after the end of treatment, the proportion of patients the treatment group and the control group SCBM was more than 3 times a week, no significant differences between the two groups of main symptoms total score of constipation (P0.05), improvement of symptoms similar to that of the first month after treatment, the patients in the treatment group were more than 3 times a week SCBM ratio is 30%, the control group accounted for 10%, two groups With statistical difference (P0.05); the main symptoms total score between the treatment group in the efficacy of maintenance is better than the control group (P0.05). The whole course of treatment, no adverse reactions were observed in two patients. Conclusion: modified Xiaoyaosan for improving women's liver blood deficiency type chronic constipation symptoms effect is obvious, especially in the aspect of traditional Chinese medicine the syndrome and long-term curative effect has more advantages.

【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R256.35

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