基于数据挖掘的孙伟教授治疗慢性肾炎用药规律研究

发布时间：2018-01-04 17:35

本文关键词：基于数据挖掘的孙伟教授治疗慢性肾炎用药规律研究　出处：《南京中医药大学》2017年硕士论文　论文类型：学位论文

【摘要】：研究目的:挖掘孙伟教授临床治疗慢性肾炎病人病案资料,通过数据库的整理,统计,分析孙教授治疗慢性肾炎的用药规律,结合孙伟教授治疗慢性肾炎的学术思想,探索治疗慢性肾炎潜在的新方,为临床治疗慢性肾脏病提供新的证据,更好的从较为客观的角度,继承和发展名中医的经验。研究方法:收集孙伟教授在江苏省中医院门诊治疗的慢性肾炎患者75例,将病人基本信息,诊疗方药录入门诊信息数据库,整理出352个处方,经规范化处理后,统计分析孙伟教授治疗慢性肾炎的药物频数、性味、归经。将其中的高频药物进行归类、并且运用SPSS软件进行聚类分析研究,统计出孙伟教授治疗慢性肾炎的核心药物组合,结合研究分析结果,探讨孙伟教授学术思想,及以此思想指导下的用药规律。研究结果:孙伟教授治疗慢性肾炎常用药物共计156味,其中核心药物有黄芪、白术、党参、石韦、土茯苓,累计使用率达50%。治疗本病主要有补虚药、清热燥湿药、活血化瘀药,其中补虚药又以补气药为主,兼有补血、养阴药。药物性味甘温药物为主,归经以肝、脾、肾经为主。最终治疗慢性肾炎的潜在新方有黄芪、白术、石韦、土茯苓、苏梗、党参、杜仲和山萸肉、枸杞子、荔枝草、金樱子等,核心药对有黄芪、党参;石韦、土茯苓;川芎、当归;泽兰、泽泻;大黄、玉米须等。结论:本研究通过数据分析挖掘展示了孙伟教授"肾虚湿瘀"理论在慢性肾炎治疗中的运用,以及"平淡中出神奇"的治疗理念和具体的用药规律。
[Abstract]:Objective: to excavate the records of Professor Sun Wei's clinical treatment of chronic glomerulonephritis and analyze the rule of professor Sun's treatment of chronic glomerulonephritis through the collation of database and statistics. Combined with Professor Sun Wei's academic thought of treating chronic nephritis, explore the potential new treatment of chronic glomerulonephritis, provide new evidence for clinical treatment of chronic kidney disease, better from a more objective point of view. Methods: 75 cases of chronic glomerulonephritis treated by Professor Sun Wei in the outpatient clinic of Jiangsu Provincial traditional Chinese Medicine Hospital were collected. The basic information of patients and the prescription of diagnosis and treatment were entered into the outpatient information database. 352 prescriptions were sorted out. After standardized treatment, professor Sun Wei's drug frequency, sexual taste and classics were statistically analyzed. The high-frequency drugs were classified. And using SPSS software cluster analysis research, statistics Sun Wei treatment of chronic glomerulonephritis of the core drug combination, combined with the results of the study, the academic thoughts of Professor Sun Wei. Results: professor Sun Wei in the treatment of chronic nephritis commonly used drugs a total of 156, among which the core drugs are Astragalus, Atractylodes macrocephala, Codonopsis pilosula, Shiwei, Tuckahoe. The cumulative utilization rate reached 50. The main treatment of this disease is deficiency medicine, heat dryness and dampness medicine, blood circulation and blood stasis medicine, among which tonifying deficiency medicine is mainly to tonify qi, and also to nourish blood, nourish yin medicine. The potential new prescription for the treatment of chronic glomerulonephritis is Astragalus membranaceus, Atractylodes macrocephala, Shiwei, Tuckahoe, Perilla thuringii, Codonopsis, Eucommia ulmoides and Cornel, Lycium chinensis, Litchi Grass, Amur etc. The core drug has Astragalus, Codonopsis pilosula; Shiwei, Poria cocos; Ligusticum chuanxiong, Angelica sinensis; Zelan, alisma; Conclusion: this study shows the application of Professor Sun Wei's theory of "Kidney deficiency and dampness stasis" in the treatment of chronic nephritis through data analysis and mining. As well as the "plain out of the magic" treatment philosophy and specific drug law.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R249;R277.5

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