类风湿关节炎发病与牙周炎的相关性分析

发布时间：2018-01-04 23:07

本文关键词：类风湿关节炎发病与牙周炎的相关性分析　出处：《新疆医科大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:分析类风湿关节炎与牙周炎的相关性,了解影响类风湿关节炎发病及疾病活动性牙周病学指标。方法:选择130例初治类风湿关节炎患者为RA组,50例未患RA的健康体检者为对照组,RA组根据牙周病指数,分为RA1组和RA2组,对RA组及对照组进行牙周病学检查和血清抗牙龈卟啉单胞菌抗体测定,同时对RA组行风湿病学相关检查,比较RA组与对照组间牙周状况及血清抗牙龈卟啉单胞菌抗体水平的异同,并分析RA患者的风湿病学与牙周病学检查指标之间的关系。结果:(1)一般资料:RA组130人,其中汉族79人,少数民族51人,年龄46.93±11.99岁。对照组50人,其中汉族36人,少数民族14人,年龄41.78±12.61岁。(2)RA组抗P.g抗体水平为40.39±55.58pg/ml;对照组抗P.g抗体水平为51.31±28.89pg/ml(t=-1.321,P=0.188)。(3)RA组中汉族与少数民族间抗P.g抗体水平差别无统计学意义(Z=-0.081,P=0.935)。对照组中汉族与少数民族间抗P.g抗体水平差别无统计学意义(Z=-0.720,P=0.472)。(4)经Pearson相关性分析,RA组血清抗P.g抗体水平与RF、抗AKA抗体、抗CCP抗体、ESR-DAS28评分及CRP-DAS28评分之间的相关性均无统计学意义。(5)RA组与对照组的牙周炎检出率的差别有统计学意义(X2=8.412,P=0.004),且易患中、重度牙周炎。(6)PDI和RA的标记性抗体抗CCP抗体呈显著正相关(r=0.398,P=0.044),但与RF、抗AKA抗体及DAS28之间均无显著相关。结论:RA患者的牙周炎检出率高于正常人群,且更易患中、重度牙周炎。牙周病指数和RA的标记性抗体抗CCP抗体呈显著正相关,但与RF、抗AKA抗体及DAS28之间均无显著相关。血清抗P.g抗体水平在RA患者和正常人群中无显著差异。血清抗P.g抗体和RA的诊断性指标(RF、抗AKA抗体及抗CCP抗体)及活动性指标(ESR-DAS28及CRP-DAS28)之间均无显著相关。
[Abstract]:Objective: to analyze the correlation between rheumatoid arthritis (RA) and periodontitis and to understand the indexes of rheumatoid arthritis (RA) and active periodontal disease. Methods: 130 patients with primary rheumatoid arthritis (RA) were selected as RA group. 50 healthy persons without RA were divided into RA1 group and RA2 group according to periodontal disease index. Periodontal diseases and serum antibodies against Porphyromonas gingivalis were detected in RA group and control group, and rheumatological examination was performed in RA group. To compare the periodontal status and serum antibody level of porphyromonas gingivalis between RA group and control group. The relationship between rheumatology and periodontal examination in RA patients was analyzed. The age was 46.93 卤11.99 years old. The control group consisted of 50 persons, including 36 Han nationality and 14 minority nationalities. The anti-P.g antibody level was 40.39 卤55.58 PG / ml in RA group aged 41.78 卤12.61 years. The level of anti-P.g antibody in the control group was 51.31 卤28.89pg / ml ~ (-1) -1.321. There was no significant difference in the level of anti-P.g antibody between Han nationality and minority nationality in group A (P < 0. 188, P < 0. 88, P < 0. 081, P < 0. 081). There was no significant difference in the level of anti-P.g antibody between Han and ethnic minorities in the control group. By Pearson correlation analysis, the serum levels of anti-P.g antibody, anti-RFR, anti-#en1# antibody and anti-#en2# antibody in RA group were analyzed. There was no significant correlation between ESR-DAS28 score and CRP-DAS28 score. There was significant difference in the detection rate of periodontitis between RA group and control group (P < 0.05). X2 + 8.412. There was a significant positive correlation between anti CCP antibody of severe periodontitis and RA, but it was associated with RF. There was no significant correlation between anti AKA antibody and DAS28. Conclusion the positive rate of periodontitis in patients with 0: RA is higher than that in normal subjects, and it is more susceptible to infection. In severe periodontitis, periodontal disease index was positively correlated with anti CCP antibody of RA, but it was associated with RF. There was no significant correlation between anti AKA antibody and DAS28. There was no significant difference in serum anti P g antibody level between RA patients and normal subjects. There was no significant correlation between anti AKA antibody and anti CCP antibody and the activity index of ESR-DAS28 and CRP-DAS28.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R593.22;R781.42

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