乳腺癌患者中血清性激素水平与甲状腺肿瘤的相关性研究

发布时间：2018-01-09 13:08

本文关键词：乳腺癌患者中血清性激素水平与甲状腺肿瘤的相关性研究　出处：《广西医科大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:探讨在乳腺癌患者中,血清性激素水平与甲状腺肿瘤之间的相互关系及其临床意义。方法:收集广西医科大学附属肿瘤医院2013年11月至2016年11月60例初诊乳腺癌并同时经甲状腺彩超发现甲状腺肿瘤的患者,作为乳腺癌合并甲状腺肿瘤组;收集同时期年龄、体重指数、月经状况、初潮年龄及孕次相匹配的初诊单纯性乳腺癌患者60例,作为单纯性乳腺癌组,该组所有患者截至随访日期前经B超或CT检查亦无甲状腺肿瘤发生;对两组患者初始治疗前采用化学发光法检测的雌激素(E2)、孕激素(P)、泌乳素(PRL)、卵泡刺激素(FSH)、黄体生成素(LH)及睾酮(T)水平进行回顾性分析;根据甲状腺彩超对甲状腺肿瘤的检查结果,按甲状腺肿瘤大小(是否大于1cm)、单发或多发及是否有恶性征象进行分组,进一步比较性激素水平与乳腺癌中的甲状腺肿瘤临床特征(大小、单发或多发及是否有恶性征象)之间的关系。统计学分析采用t检验及非参数秩和检验。结果:乳腺癌合并甲状腺肿瘤组与单纯性乳腺癌组患者的各项性激素水平比较结果显示:乳腺癌合并甲状腺肿瘤组E2水平中位数较单纯性乳腺癌组高,差异有统计学意义(P=0.03);乳腺癌合并甲状腺肿瘤组PRL水平较单纯性乳腺癌组低,差异有统计学意义(P=0.001)。而P、FSH、LH及T水平两组之间差异无统计学意义(P值分别为0.109、0.337、0.295、0.104,P0.05)。对乳腺癌中的甲状腺肿瘤大小(是否大于1cm)、单发多发及是否有恶性征象进行分组,各组之间的E2、PRL水平差异无统计学意义(P0.05)。结论:1、乳腺癌合并甲状腺肿瘤患者和单纯性乳腺癌患者相比,血清E2水平升高,PRL水平降低,提示E2及PRL水平的变化可能与甲状腺肿瘤的发生有关。2、乳腺癌并发甲状腺肿瘤时,血清E2与PRL水平与甲状腺肿瘤的大小、单发多发及是否有恶性征象之间无明显相关性。
[Abstract]:Objective: to explore the diagnosis of breast cancer. The relationship between serum sex hormone level and thyroid tumor and its clinical significance. Methods:. From November 2013 to November 2016, 60 patients with breast cancer were collected from affiliated Cancer Hospital of Guangxi Medical University. As a group of breast cancer with thyroid neoplasms; A total of 60 patients with primary breast cancer who were matched with age, BMI, menstrual status, menarche age and pregnancy were collected as simple breast cancer group. All patients in this group had no thyroid neoplasms by B-ultrasonography or CT before the follow-up date. The estradiol, progesterone, prolactin (PRL) and follicle stimulating hormone (FSHs) were detected by chemiluminescence before initial treatment in both groups. The levels of luteinizing hormone (LH) and testosterone (T) were analyzed retrospectively. According to the results of thyroid tumors by thyroid color Doppler ultrasound, the thyroid tumors were grouped according to their size (> 1 cm), single or multiple, and malignant signs. To further compare sex hormone levels with the clinical features of thyroid tumors in breast cancer. Single or multiple and malignant signs). T test and nonparametric rank sum test were used in statistical analysis. Results: sex hormone levels in patients with breast cancer combined with thyroid neoplasms were compared with those in patients with simple breast cancer. The median E _ 2 level in breast cancer with thyroid neoplasms was higher than that in simple breast cancer. The difference was statistically significant (P < 0. 03). The level of PRL in breast cancer with thyroid tumor group was lower than that in simple breast cancer group, the difference was statistically significant. There was no significant difference in LH and T levels between the two groups (P = 0.109) and 0.337U 0.295 (0.104), respectively. P0.05. the size of thyroid tumor in breast cancer (> 1 cm), single multiple and malignant signs were divided into groups, E2 among each group. There was no significant difference in serum E 2 level between breast cancer patients with thyroid tumor and simple breast cancer patients (P 0.05). Conclusion compared with simple breast cancer patients, serum E 2 level is higher and lower than that in breast cancer patients with thyroid neoplasms. These results suggest that the changes of E2 and PRL levels may be related to the occurrence of thyroid neoplasms. The serum E2 and PRL levels and the size of thyroid neoplasms may be related to the occurrence of thyroid tumors in breast cancer. There was no significant correlation between single multiple and malignant signs.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R737.9;R736.1

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