血清PSA、PSAD预测前列腺癌骨转移的临床价值分析

发布时间：2018-01-11 00:07

本文关键词：血清PSA、PSAD预测前列腺癌骨转移的临床价值分析　出处：《新疆医科大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:探讨血清前列腺特异性抗原(PSA)及前列腺特异性抗原密度(PSAD)应用于预测前列腺癌骨转移的临床价值。方法:回顾性分析我院2010年1月-2016年10月经前列腺穿刺活检确诊的前列腺癌患者63例,均行核素骨扫描检查,根据检查结果分为前列腺骨转移组及前列腺癌非骨转移组,对两组患者的PSA及PSAD水平进行分析,得出PSA及PSAD与前列腺癌骨转移的关系。结果:前列腺癌骨转移组及非骨转移组的PSA及PSAD水平存在统计学差异。以PSA20ng/ml作为诊断标准预测前列腺癌骨转移,灵敏度为89.7%,特异度为76.5%,以血清PSAD0.4ng/(ml·cm3)作为诊断标准预测前列腺癌骨转移,灵敏度为86.2%,特异度为73.5%,两者的ROC曲线下面积分别为0.919和0.866,以血清PSA20ng/ml联合PSAD0.4 ng/(ml·cm3)作为标准预测临床前列腺癌骨转移,诊断的灵敏度为86.2%,特异度为85.3%。结论:PSA及PSAD均可应用于前列腺癌骨转移的预测,两者联合应用可提高前列腺癌骨转移的诊断价值,对于血清PSA20ng/ml联合PSAD0.4ng/(ml·cm3)的患者应高度怀疑骨转移的存在,积极进行骨扫描确定诊断。
[Abstract]:Objective: to study serum prostate specific antigen (PSA) and prostate specific antigen density (PSAD). Methods: 63 cases of prostate cancer diagnosed by prostate biopsy from January 2010 to 2016 were analyzed retrospectively. All patients were examined by bone radionuclide scan. According to the results, the patients were divided into two groups: bone metastasis group and non-bone metastasis group. The levels of PSA and PSAD in both groups were analyzed. The relationship between PSA and PSAD and bone metastasis of prostate cancer was obtained. The levels of PSA and PSAD in bone metastasis group and non-bone metastasis group were statistically different. PSA20ng/ml was used as diagnostic criterion to predict bone metastasis of prostate cancer. The sensitivity was 89. 7 and the specificity was 76. 5. Serum PSAD0.4ng/(ml 路cm 3 was used as diagnostic criteria for predicting bone metastasis of prostate cancer. The sensitivity was 86.2%. The specificity was 73.5 and the area under the ROC curve was 0.919 and 0.866, respectively. Serum PSA20ng/ml combined with PSAD0.4 ng/(ml 路cm 3 was used to predict bone metastasis of prostate cancer. The diagnostic sensitivity was 86.2%. Conclusion both PSAD and PSAD can be used to predict bone metastasis of prostate cancer, and the combination of them can improve the diagnostic value of bone metastasis of prostate cancer. For patients with serum PSA20ng/ml combined with PSAD0.4ng/(ml 路cm 3, bone metastasis should be highly suspected and bone scan should be actively performed to determine the diagnosis.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R737.25

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