滋阴补阳方治疗肾虚型RIF的临床研究

发布时间：2018-01-13 19:11

本文关键词：滋阴补阳方治疗肾虚型RIF的临床研究　出处：《南京中医药大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:观察滋阴补阳方治疗肾虚型反复种植失败的临床疗效,探讨滋阴补阳中药是否改善肾虚型RIF患者的临床结局及其可能的作用机理,为中西医结合治疗该病提供新的思路和方法。方法:将54例研究对象随机分为治疗组和对照组,对照组服用多维元素片每日1片,连用3个月经周期后进入移植周期,移植周期不停药。治疗组在对照组的基础上,加用滋阴补阳方序贯调治3个周期,移植周期亦不停药。比较两组中医证候、内分泌激素、子宫内膜容受性、胚胎着床率和临床妊娠率等,评估滋阴补阳方治疗肾虚型RIF的总体疗效。结果:①治疗组治疗后肾虚、月经症状积分均比治疗前低,有显著差异(P0.01);组间对比,治疗组治疗后总积分显著低于对照组(P0.01)。②治疗组患者治疗后FSH较治疗前降低,差异有统计学意义(P0.01),治疗前后E2、LH、AMH无明显差异(P0.05);组间比较,两组患者治疗后只有FSH比较有显著差别(P0.01)。③治疗组患者子宫内膜厚度、体积、A型子宫内膜数、PI、RI、VI治疗后均较治疗前改善,差异有统计学意义(P0.05)。组间比较:治疗组患者治疗后内膜的厚度、体积、A型子宫内膜比例、VI均高于对照组,PI低于对照组,有明显差异(P0.05);治疗组RI治疗后有下降趋势,但与对照组相比,无明显差别(P0.05)。④治疗组治疗后9例妊娠,2例生化妊娠,临床妊娠率36%,胚胎着床率26%,总有效率92%;对照组4例妊娠,3例生化妊娠,临床妊娠率15.38%,胚胎着床率9.62%,总有效率为38.46%。结论:滋阴补阳方能改善肾虚型RIF患者的肾虚证候、月经症状、子宫内膜容受性,降低FSH水平,提高胚胎着床率,并有望进一步提高临床妊娠率。
[Abstract]:Objective: to observe the clinical effect of nourishing yin and tonifying yang prescription in the treatment of repeated implantation failure of kidney deficiency type, and to explore whether the traditional Chinese medicine for nourishing yin and reinforcing yang can improve the clinical outcome and possible action mechanism of RIF patients with kidney deficiency type. Methods: 54 patients were randomly divided into treatment group and control group. Treatment group on the basis of the control group, the treatment group with yin tonifying Yang prescription sequential treatment of 3 cycles, the transplantation cycle is also non-stop drugs. Compare the two groups of TCM syndrome. Endocrine hormone, endometrial receptivity, embryo implantation rate and clinical pregnancy rate were evaluated to evaluate the overall efficacy of Ziyin Buyang recipe in the treatment of kidney deficiency type RIF. The scores of menstrual symptoms were significantly lower than those before treatment (P 0.01). The total score of the treatment group was significantly lower than that of the control group after treatment, the FSH of the treatment group was significantly lower than that of the pre-treatment group, the difference was statistically significant (P 0.01). There was no significant difference in AMH between before and after treatment (P 0.05). There was significant difference in endometrial thickness and volume of type A endometrium between the two groups after treatment with FSH. VI was improved after treatment, the difference was statistically significant (P 0.05). Comparison between groups: the thickness of endometrium and volume of type A endometrium in the treatment group were higher than those in the control group. Pi was lower than that of control group (P 0.05). The RI of the treatment group decreased after treatment, but there was no significant difference between the treatment group and the control group (P 0.054.The clinical pregnancy rate was 36%). The embryo implantation rate was 26% and the total effective rate was 92%. The clinical pregnancy rate was 15.38 and the embryo implantation rate was 9.62%. The total effective rate was 38.46.Conclusion: the prescription of nourishing yin and tonifying yang can improve the syndrome of kidney deficiency, menstrual symptoms, endometrial receptivity, decrease the level of FSH and increase the rate of embryo implantation in RIF patients with kidney deficiency. It is expected to further improve the clinical pregnancy rate.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R271.9

【相似文献】