基于ALFF的OSAHS患者脑功能变化及临床相关研究

发布时间：2018-01-15 19:10

本文关键词：基于ALFF的OSAHS患者脑功能变化及临床相关研究　出处：《新疆医科大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:探索阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea-hypopnea syndrome,OSAHS)患者和正常对照组的大脑神经元自发活动差异及其与OSAHS严重程度的关系。方法:收集30例OSAHS患者及体检健康者23例,均接受静息态功能磁共振(resting-state functional magnetic resonance imaging,rs-fMRI)扫描及MoCA评分,患者组进行多导睡眠监测,并在磁共振扫描前24h内进行了上气道CT测量,对两组图像数据进行处理比较并进行相关性分析。结果:与HC组相比,OSAHS组双侧海马旁回、颞叶及梭状回、右侧额叶及左侧小脑低频振幅活动明显增强,差异具有统计学意义(P0.005);双侧顶叶、两侧楔前叶及前扣带回的低频振幅活动减弱,差异具有统计学意义(P0.005);经Pearson相关性分析结果显示,双侧海马旁回、颞叶及梭状回与OSAHS组ALFF呈负相关,双侧顶叶ALFF值与OSAHS患者的呼吸暂停低通气指数(apnea-hypopnea index,AHI)呈显著负相关(P0.005);双侧楔前叶及前扣带回的ALFF值与MoCA评分之间呈显著正相关(P0.005)。结论:fMRI技术能够探测到OSAHS患者脑组织功能发生的变化,为OSAHS患者和正常对照者的鉴别与诊断提供有效的影像学方法。
[Abstract]:Objective: to explore obstructive sleep apnea-hypopnea syndrome in obstructive sleep apnea hypopnea syndrome. The relationship between the spontaneous activity of brain neurons and the severity of OSAHS in patients with OSAHS and normal controls. Methods: 30 patients with OSAHS and 23 healthy controls were collected. All patients received rest state functional magnetic resonance imaging. Rs-fMRI (rs-fMRI) scan and MoCA score, polysomnography was performed in the patient group, and the upper airway CT was measured within 24 hours before Mr scan. Results: compared with HC group, OSAHS group had bilateral parahippocampal gyrus, temporal lobe and fusiform gyrus. The low frequency amplitude activity in the right frontal lobe and left cerebellum was significantly increased (P 0.005). In bilateral parietal lobe, the low frequency amplitude activity of bilateral anterior cuneate lobe and anterior cingulate gyrus decreased, and the difference was statistically significant (P 0.005). The results of Pearson correlation analysis showed that bilateral parahippocampal gyrus, temporal lobe and fusiform gyrus were negatively correlated with ALFF in OSAHS group. Bilateral parietal lobe ALFF was negatively correlated with apnea hypopnea index (P0.005) in patients with OSAHS. There was a significant positive correlation between ALFF and MoCA score in bilateral anterior wedge and anterior cingulate gyrus (P0.005). Conclusion the brain tissue function of patients with OSAHS can be detected by the technique of FMRI. To provide an effective imaging method for the differentiation and diagnosis of OSAHS patients and normal controls.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R766;R445.2

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