口腔科住院患者幽门螺杆菌感染现状调查及临床分析

发布时间：2018-01-20 00:21

  本文关键词： 幽门螺杆菌 口腔疾病 感染　出处：《大连医科大学》2017年硕士论文　论文类型：学位论文

【摘要】：研究目的:通过调查研究口腔科住院患者对幽门螺杆菌的认知情况及患者唾液内幽门螺杆菌感染现状,并对多种致感危险因素进行分析,总结口腔幽门螺杆菌同口腔科疾病的联系要点,为临床预防治疗提供数据支持及指导。研究对象及方法:选取对象为2016年7月～2016年12月间于大连医科大学附属第一医院口腔颌面外科病房就诊住院的患者,使用自制调查问卷,对患者幽门螺杆菌认知情况打分并记录结果。使用幽门螺杆菌尿素酶快速检测试剂盒(干化学法)对患者进行口内唾液幽门螺杆菌检测,记录检测结果;对测试患者进行年龄,性别,确定诊断,吸烟饮酒史及既往全身慢性疾病史等相关数据统计,使用SPSS20.0对相关数据进行统计学分析,组间数据对比使用卡方检验,P0.05为有统计学意义。研究结果:根据幽门螺旋杆菌认知度调查问卷调查,患者对幽门螺杆菌的认知率整体较低,缺乏相关方面的知识;在407位受检住院患者中,唾液幽门螺杆菌感染结果为阳性的患者有312位,占总体的76.66%;男性246人,幽门螺杆菌感染率77.24%,女性患者总人数161人,感染率为75.78%,性别差异无统计学意义(P0.05);不同年龄组幽门螺杆菌感染率,随年龄增长先上升后下降,30岁至50岁的中青年人群感染率升高,30岁以下及70岁以上患者感染率下降;不同口腔颌面外科疾病种类的患者H.pylori感染率,各组间相比,差异没有统计学意义(P0.05),其中口腔颌面部感染性疾病患者34人,感染率为79.41%,其次为口腔颌面部肿瘤患者146人,感染率为78.77%;慢性疾病患者的幽门螺杆菌感染率较高,54位高血压患者感染率83.33%,11位糖尿病患者阳性率为100%,13位同时罹患两种慢性病患者的感染率为92.31%,329位无上述两种慢性病患者的阳性率为74.16%,前三组感染率与最后一组分别比较,差异有统计学意义;受测人群中,吸烟者有144人,感染率90.97%,22位有饮酒患史者感染率为86.36%,同时有吸烟史及饮酒史的患者感染率最高,为96.08%,无吸烟史及饮酒史患者的感染率为59.47%,吸烟组、饮酒组、吸烟及饮酒组感染率分别与之相比,差异均具有统计学意义(P0.05)。研究结论:1.调查结果表明住院患者对幽门螺杆菌认知度较低,大部分患者不了解幽门螺杆菌的危害性以及是导致多种全身系统疾病的致病菌之一;应加强三级预防工作,做好相关知识普及,尤其是对口腔致病菌的危害性的宣教。2.本院口腔科住院患者幽门螺杆菌感染率76.66%,高于国内现有报道的健康人群感染率(30～60%)。针对口腔科患者的H.pylori检测很有必要,H.pylori的检出率可指示某些口腔相关疾病的存在。中青年为幽门螺杆菌感染高发人群,高血压、糖尿病及吸烟饮酒史与感染率高低正相关。3.幽门螺杆菌在口腔疾病中的作用及其与引起胃肠道疾病的机制相互间的关系,口腔幽门螺杆菌感染后的治疗条件、最佳治疗方案及检测手段仍需更多的理论研究探索,望成为今后研究重点。
[Abstract]:Objective: through the investigation and study status quo of Department of Stomatology patients with Helicobacter pylori infection of Helicobacter pylori in saliva of patients with cognition and hospitalization, and several induced risk factors were analyzed, summed up the contact points of oral Helicobacter pylori with diseases in Department of Stomatology, to provide data support and guide the treatment for clinical prevention. Subjects and methods: the selected object for the July 2016 to December 2016 in the First Affiliated Hospital of Dalian Medical University Department of oral and maxillofacial surgery ward treatment of hospitalized patients, using self-made questionnaire on Helicobacter pylori in patients with cognitive score and record the results. The rapid detection kit of Helicobacter pylori urease (dry chemical method) of patients were detected in saliva of Helicobacter pylori, recording the detection results of the test; age, gender, diagnosis and the smoking and drinking history and past history of chronic disease such as systemic Relevant statistical data, using SPSS20.0 statistical analysis of related data, data comparison between groups using chi square test, P0.05 had statistical significance. Results: according to H.pylori cognition questionnaire investigation on cognition in Helicobacter pylori infection rate is low, the lack of relevant knowledge; in 407 subjects in hospital in patients with Helicobacter pylori infection in saliva of patients with positive results for 312, accounted for 76.66% of the total; 246 men, 77.24% rate of Helicobacter pylori infection, the total number of 161 female patients, the infection rate was 75.78%, there was no significant difference (P0.05); different age groups of Helicobacter pylori infection rate. The first increased and then decreased with the increase of age 30 to 50 years old young people increased infection rate, rate of decline under the age of 30 and 70 years of age of infection in patients with oral and maxillofacial diseases; different types of patients and the infection rate of H.pylori, Between groups were compared, the difference was not statistically significant (P0.05), including oral and maxillofacial infections in 34 patients, the infection rate was 79.41%, followed by patients with oral and maxillofacial tumor 146, the infection rate was 78.77%; a higher rate of Helicobacter pylori infection in patients with chronic diseases, 54 patients with hypertension infection rate was 83.33%. 11 in diabetic patients the positive rate was 100%, 13 and two suffering from chronic disease infection rate was 92.31%, 329 of the two kinds of chronic diseases in patients with positive rate of 74.16%, the three groups were compared with the infection rate of the last group, the difference was statistically significant; measured by the crowd, there are 144 smokers people, the infection rate was 90.97%, the infection rate of 22 patients with alcohol history was 86.36%, while the highest rate of patients with history of smoking and drinking history of infection was 96.08%, smoking and drinking history of patients with the infection rate was 59.47%, the smoking group, smoking and alcohol drinking group, infection group Rates were compared, the differences were statistically significant (P0.05). Conclusion: the survey results show that 1. of hospitalized patients on Helicobacter pylori awareness is low, most patients do not understand the harm of Helicobacter pylori and pathogen causing many systemic diseases is one of the primary prevention should be strengthened; three, good the popularization of knowledge, especially for the harm of oral pathogens in our hospital department of stomatology hospital mission.2. patients with Helicobacter pylori infection rate of 76.66%, higher than the healthy population of domestic existing reported infection rate (30 ~ 60%). It is necessary for the detection of H.pylori Department of Stomatology patients, the detection rate can indicate some oral diseases related to the presence of H.pylori the youth. In high-risk population, Helicobacter pylori infection, hypertension, diabetes and smoking and drinking history and the infection rate level is positively related to the.3. of Helicobacter pylori in oral diseases and for The relationship between the mechanism of gastrointestinal diseases and the treatment conditions of oral Helicobacter pylori infection, the best treatment and detection methods still need more theoretical research and exploration.

【学位授予单位】：大连医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R78
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本文编号：1446095