乳腺非特殊型浸润性癌淋巴管瘤栓分级与预后相关性分析

发布时间：2018-01-28 12:12

本文关键词： 乳腺非特殊型浸润性癌临床特征淋巴管瘤栓分级预后　出处：《河北医科大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:探讨乳腺非特殊型浸润性癌(Invasive carcinomas of no special type,ICNST)的淋巴管瘤栓分级与预后相关性分析。方法:回顾性分析河北医科大学第四医院2006年1月-2008年12月确诊的ICNST患者共466例,整理患者的临床病理资料,并进行D2-40、ER、PR和HER2免疫组化染色,确定肿物淋巴管瘤栓及个数,并按照每高倍视野瘤栓核分裂及凋亡细胞数进行分级。电话随访患者的生存时间,采用spearman检验进行相关分析,Kaplan-Meier曲线描述患者生存率,Log-rank检验及Cox风险回归模型进行生存时间影响因素分析。结果:466例ICNST患者中,淋巴管瘤栓0级280例(60.09%),1级112例(24.03%),2级58例(12.45%),3级16例(3.43%)。相关分析结果表明:淋巴管瘤栓分级与淋巴结转移个数呈正相关(P0.001);单因素生存分析显示:ICNST患者组织学分级、淋巴管瘤栓分级、淋巴结转移个数、ER、PR、HER2表达及分子分型与ICNST患者生存时间相关(P0.05)。Cox比例风险模型多因素分析显示,淋巴管瘤栓分级及淋巴结转移个数情况是影响ICNST患者生存时间的独立预后因素(P0.05)。结论:ICNST患者的淋巴管瘤栓分级及淋巴结转移个数情况可预测其预后,提示病理医师要对这一特征予以关注。
[Abstract]:Objective: to investigate the invasive carcinomas of no special type in breast. ICNST). Methods: a total of 466 patients with ICNST diagnosed from January 2006 to December 2008 in 4th Hospital of Hebei Medical University were retrospectively analyzed. The clinicopathological data of the patients were collected and the number and number of lymphangioma embolus were determined by immunohistochemical staining of D2-40 ERN PR and HER2. According to the number of mitotic and apoptotic cells per high-power field tumor thrombus, the survival time of the patients was followed up by telephone, and the correlation analysis was carried out by spearman test. The survival rate was described by Kaplan-Meier curve. Log-rank test and Cox risk regression model were used to analyze the factors affecting survival time. Results among 466 patients with ICNST, 280 cases had lymphangioma thrombus grade 0 (60.09%). Grade 1, 112 cases (24.03) and grade 2 (58 cases, 12.45). The results of correlation analysis showed that the classification of lymphangioma thrombus was positively correlated with the number of lymph node metastasis (P 0.001). Univariate survival analysis showed histological grade, lymphangioma thrombus grade, lymph node metastasis and ERPR in the patients with ICNST. HER2 expression and molecular typing were correlated with survival time of ICNST patients. The classification of lymphangioma thrombus and the number of lymph node metastases were independent prognostic factors influencing the survival time of ICNST patients (P0.05). Conclusion the classification of lymphangioma thrombus and the number of lymph node metastases in patients with ICNST can predict the prognosis. It suggests that pathologists should pay attention to this feature.
【学位授予单位】：河北医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R737.9

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