清热利湿方治疗痤疮疗效观察及痤疮患者面部特征定量分析

发布时间：2018-01-28 23:40

本文关键词： 痤疮清热利湿方疗效评价 VISIA 面部特征　出处：《南京中医药大学》2017年硕士论文　论文类型：学位论文

【摘要】：研究目的:探究清热利湿方治疗湿热蕴结型痤疮的疗效及痤疮患者面部特征分析。研究方法:门诊选取65例湿热蕴结型痤疮患者及20例健康受试者,痤疮患者随机分为治疗组33例和对照组32例,治疗组予清热利湿方中药汤剂口服,阿达帕林凝胶、氧氟沙星凝胶外用,对照组仅外用药膏,药物疗程为4周,患者分别于治疗前、治疗后4周进行皮损、症状积分评估。同时,痊愈病例在治疗结束后2个月进行随访,对受试者的病情变化、复发率情况进行记录。应用VISIA面部图像分析系统拍摄健康受试者及痤疮患者治疗前的面部照片,并记录皮肤色素斑、皱纹、纹理、毛孔、红色区和紫质的绝对分值。将每位受试者所有数据输入计算机,与健康受试者结果进行比较,经统计学处理分析痤疮患者与健康受试者皮肤特点及各项指标之间的关系。研究结果:治疗4周后,治疗组的皮损有效率为87.88%,对照组的皮损有效率为68.75%,治疗组的症状皮损综合症候的有效率为90.91%,对照组的综合症候有效率为62.50%,且两组的差异具有统计学差异(P0.05),对综合症候痊愈的患者治疗结束2月后进行随访,治疗组随访6例,复发1例,对照组随访1例,复发1例;痤疮患者在毛孔、紫质、红斑区的VISIA数值均高于健康受试者,且差异具有统计学意义(P0.05)。结论:清热利湿方治疗湿热蕴结型痤疮安全有效、复发率低;痤疮患者相较于健康受试者的不同主要表现在肤质的粗糙、皮肤痤疮丙酸杆菌的数量增多及皮肤炎症较高、肤色的改变,综合以上,VISIA面部图像分析仪对面部色素斑、皱纹、纹理、紫质、红色区的定量分析,或许可为痤疮的治疗效果带来一种更加客观、直观的临床评价办法。
[Abstract]:Objective: to analyze the efficacy and characteristics of facial acne patients qingrelishi side treatment of damp heat accumulation type acne. Methods: We selected 65 cases of outpatient shireyunjiexing acne patients and 20 healthy subjects, patients with acne were randomly divided into treatment group 33 cases and control group 32 cases, treatment group was treated with qingrelishi side Decoction oral, topical Adapalene Gel, Ofloxacin Gel, the control group was treated with ointment, drug treatment for 4 weeks, patients in the treatment of skin lesions before and after 4 weeks of treatment, symptom assessment. At the same time, cured cases were followed up for 2 months after the end of treatment, the subjects of the condition changes, the recurrence rate was recorded. Application of VISIA facial image analysis system in the treatment of patients taken in healthy subjects and acne before facial photographs, and recorded the skin pigment spots, wrinkles, texture, pore, red zone and Br absolute score. Each subject The subjects all the data into the computer, and the results were compared with healthy subjects, after statistical analysis of the relationship between acne patients and healthy subjects between the skin characteristics and indicators. Results: after 4 weeks of treatment, the lesions of the treatment group was 87.88%, the lesions of control group was 68.75%, syndrome the symptoms of skin lesions in treatment group the syndrome rate was 90.91%, the effective rate of control group was 62.50%, and the differences in the two groups had statistical differences (P0.05), follow-up of patients recovered syndrome treatment end after February, the treatment group 6 cases were followed up, 1 cases of recurrence, 1 cases of control group were followed up, recurrence in 1 cases of acne patients; in the pores, porphyrin, VISIA numerical erythema area were higher than that in healthy subjects, and the difference was statistically significant (P0.05). Conclusion: qingrelishi side is safe and effective in the treatment of damp heat accumulation type acne, acne patients compared with low recurrence rate; Different from healthy subjects is mainly manifested in the rough skin, skin inflammation and high number of skin P.acnes increased, the change of colour, based on the above, VISIA facial image analysis of facial pigmentation, wrinkles, texture, porphyrin, quantitative analysis of the red zone, or permission for the treatment of acne bring a kind of effect more objective, clinical evaluation methods are intuitive.

【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R275.9

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