太极拳对帕金森病患者身心健康的影响及生化机制研究

发布时间：2018-02-20 15:27

本文关键词： 太极拳帕金森病运动功能生活质量机制生化指标　出处：《上海体育学院》2017年硕士论文　论文类型：学位论文

【摘要】：研究目的:帕金森病(PD)是一种复杂的神经退行性疾病,包括运动和非运动症状。PD伴发抑郁是PD患者最常见的非运动症状之一,目前尚无可逆性的治愈方法,因此,缓解PD患者的症状并提高其身心健康显得极其重要。本研究通过观察6个月有规律的太极拳练习对PD患者日常生活质量、运动功能及焦虑抑郁的影响,以及血液中5-羟色胺(5-HT)及其代谢物5-羟基吲哚乙酸(5-HIAA)、去甲肾上腺素(NE)及其代谢物高香草酸(HVA)和多巴胺(DA)及其代谢物二羟基苯乙酸(DOPAC)的变化,进一步探讨太极拳对PD患者身心健康的作用及内在生化调节机制。为PD患者的运动康复治疗提供理论和方法依据;同时对中国传统武术太极拳的科学化传播和发展具有理论和应用价值。研究对象与方法:自2016年5月—2016年12月,将通过中国人民解放军411医院以及上海市招募符合要求的16例(去除中途脱落的患者)PD患者作为实验对象,随机分为两组:实验组和对照组,每组各有8例。实验组进行太极拳练习,对照组进行普通拉伸运动及步态练习,两组患者每周均进行2次,每次60min,持续6个月。实验前后生活质量采用PDQ-39量表进行评分,运动功能采用UPDRS量表评价,抑郁及焦虑情况采用HAMD和HAMA量表评价,生化指标采用5-HT、5-HIAA、NE、HVA、DA、DOPAC进行评价。研究结果:1.生活质量6个月运动干预之后,实验组的日常生活质量(PDQ-39)总分较实验前有大幅下降,且实验前后相比差异具有显著性(P0.05)。实验后,实验组的日常生活质量比对照组有了明显提高,且差异具有显著性(P0.05)。2.UPDRS(I-Ⅲ)6个月运动干预之后,UPDRS I在精神、行为和情绪评分上实验组实验后大幅低于实验前,且实验前后比较差异具有显著性(P0.05);实验后两组比较差异具有显著性(P0.05)。UPDRS II在日常生活活动能力评分上实验组实验后大幅低于实验前,且实验前后比较差异具有显著性(P0.05);而对照组实验后评分与实验前相比略有升高;实验后两组比较差异具有显著性(P0.05)。UPDRS Ⅲ在运动功能评分上实验组实验后较实验前相比有大幅降低,且实验前后比较差异具有显著性(P0.05);实验后两组比较差异具有显著性(P0.05)。3.焦虑6个月运动干预之后,在HAMA得分上实验组实验后较实验前相比有大幅降低,且实验前后比较差异具有显著性(P0.05);实验前两组比较差异不具有显著性(P0.05),实验后两组比较差异具有高度显著性(P0.01)。4.抑郁6个月运动干预之后,在HAMD总分上实验组实验后较实验前相比有显著降低,且实验前后比较差异具有显著性(P0.05);实验前两组比较差异不具有显著性(P0.05),实验后两组比较差异具有显著性(P0.05)。5.生化指标6个月运动干预之后,在血清5-HT及其代谢物5-HIAA含量上,实验组实验后较实验前相比有显著升高,且实验前后比较差异具有显著性(P0.05);实验前两组比较差异不具有显著性(P0.05),实验后两组比较差异具有显著性(P0.05)。6个月运动干预之后,在血清NE及其代谢物HVA含量上,实验组实验后较实验前相比有显著升高,且实验前后比较差异具有显著性(P0.05);实验前两组比较差异不具有显著性(P0.05),实验后两组比较差异具有显著性(P0.05)。6个月运动干预之后,在血清DA及其代谢物DOPAC含量上,实验组实验后较实验前相比有显著升高,且实验前后比较差异具有显著性(P0.05);实验前两组比较差异不具有显著性(P0.05),实验后两组比较差异具有显著性(P0.05)。结论:1.太极拳练习对PD患者日常生活质量具有明显的改善作用。2.太极拳练习能有效的改善PD患者的情绪及身心整体功能,尤其体现在改善抑郁和焦虑方面。3.太极拳练习对PD患者外周血液中5-HT、5HIAA、NE、HVA、DA、DOPAC均有显著的改善,推测这些血液指标与PD伴发抑郁具有相互关系。
[Abstract]:Objective: Parkinson's disease (PD) is a complex neurodegenerative diseases, including motor and non motor symptoms of depression in.PD is one of the most common non motor symptoms in patients with PD, there is no reversible cure, therefore, alleviate the symptoms of PD patients and improve their physical and mental health is very important. The aim of this study was 6 months of Taijiquan Exercise on quality of life in patients with PD, effects of exercise function and anxiety and depression, and 5- in the blood serotonin (5-HT) and its metabolite 5- hydroxyindoleacetic acid (5-HIAA), norepinephrine (NE) and its metabolite homovanillic acid (HVA) and dopamine (DA) and its metabolite two hydroxy phenyl acetic acid (DOPAC) changes, further discussion of Taijiquan on the PD physical and mental health of the patients and the role of intrinsic biochemical regulatory mechanism. To provide theoretical and methodological basis for the treatment of exercise rehabilitation in patients with PD; at the same time to pass China Which has theoretical and practical value of traditional Wushu Taijiquan scientific communication and development. The research object and methods: from May 2016 to December 2016, the Chinese people's Liberation Army 411 Hospital of Shanghai City, who met the requirements of 16 patients (removal of expulsion of patients) in patients with PD as experimental object, randomly divided into two groups: experiment group and control group, with 8 cases in each group. The experimental group of Taijiquan exercise control group and exercise ordinary stretch gait training in two groups, were 2 times a week, every time 60min, lasted for 6 months. The quality of life before and after the experiment using the PDQ-39 scale score, motor function evaluated by UPDRS scale depression and anxiety, using HAMD and HAMA scale evaluation, biochemical index by 5-HT, 5-HIAA, NE, HVA, DA, DOPAC were evaluated. Results: 1. after 6 months of exercise intervention on quality of life, quality of life of the experimental group (PDQ-39) The total score decreased significantly compared with those before the experiment, and the experiment before and after compared with significant difference (P0.05). After the experiment, the quality of daily life in the experimental group than the control group was obviously improved, and the difference was significant (P0.05).2.UPDRS (I- III) after 6 months of exercise intervention, UPDRS I in the spirit, and behavior the experimental group after the experiment on mood scores significantly lower than before the experiment, and there was significant difference between before and after the experiment (P0.05); the difference between the two groups was significant after the experiment (P0.05).UPDRS II in the activities of daily living scores of the experimental group after the experiment is significantly lower than before the experiment, and there was significant difference between before and after the experiment (P0.05); and the control group after the experiment compared with the score before the experiment increased slightly; the difference between the two groups was significant after the experiment (P0.05).UPDRS III experimental group in motor function score after than before the experiment significantly decreased compared to before the experiment, and After comparing the difference was significant (P0.05); the difference between the two groups was significant after the experiment (P0.05) after 6 months of exercise.3. anxiety intervention, HAMA score in the experimental group after the experiment than before the experiment significantly decreased compared to before and after the experiment, and the difference was significant (P0.05) between the two groups before the experiment; the difference was not significant (P0.05), the difference between the two groups has a significant difference after the experiment (P0.01) after.4. depression 6 months of exercise intervention, the total score of HAMD in the experimental group after the experiment is compared before the experiment significantly reduced, and the difference between before and after the experiment was significant (P0.05); the two groups before experiment the difference was not significant (P0.05), the difference between the two groups was significant after the experiment (P0.05) after.5. biochemical indexes 6 months exercise intervention on serum 5-HT and its metabolite 5-HIAA content, the experimental group after the experiment was significantly increased compared to before the experiment, and the experiment The difference was significant (P0.05); the difference between the two groups was not significant (P0.05), the difference between the two groups was significant after the experiment (P0.05) after.6 months of exercise intervention, the serum NE and its metabolite HVA content, the experimental group after the experiment was significantly increased compared to before before and after the experiment, and the difference was significant (P0.05); the difference between the two groups was not significant (P0.05), the difference between the two groups was significant after the experiment (P0.05) after.6 months of exercise intervention, the serum DA and its metabolite DOPAC content, the experimental group after the experiment was compared with before experiment before and after the experiment were significantly increased, and the difference was significant (P0.05); the difference between the two groups was not significant (P0.05), the difference between the two groups was significant after the experiment (P0.05). Conclusion: 1. Taijiquan Exercise on quality of life in patients with the PD The effect of Taijiquan exercise can.2. the whole function of emotional and physical improvement of PD patients effectively, especially the practice of PD in peripheral blood of patients with 5-HT, in the improvement of depression and anxiety of.3. 5HIAA Chi NE, HVA, DA, DOPAC, significant improvements have speculated that the blood index and associated with PD depression has a relationship.

【学位授予单位】：上海体育学院
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R742.5;G852.11

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