维汉两民族根管治疗术后疼痛反应及镇痛效果的对比研究

发布时间：2018-03-03 19:45

本文选题：布洛芬　切入点：慢性根尖周炎　出处：《新疆医科大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:观察汉族与维吾尔族患者慢性根尖周炎行一次法根管治疗术后疼痛发生率及剧烈程度的差异,同时比较不同民族间布洛芬对于根管治疗术后镇痛效果的差异,为临床治疗提供参考。方法:本次临床实验分两个阶段,第一阶段(预实验)临床实验随机选取汉族、维吾尔族慢性根尖周炎患者各30名。汉族患者年龄在16至39岁之间有28人,40至59岁之间有2人,其中男性11人,女性19人;维吾尔族患者年龄在16至39岁之间有27人,40至59岁之间有3人,其中男性15人,女性15人。采用冠向下法行根管治疗,治疗结束后记录相关数据,统计各组根管治疗后疼痛(endodontic flare-up,E flare-up)发生率和急性发作指数(Flare-up index,FUI)。第二阶段实验随机选取汉族、维吾尔族单根管慢性根尖周炎患者各250人,行一次法根管治疗后,按照随机双盲的原则,将汉族患者术后分为实验组(汉)和对照组(汉);将维吾尔族患者术后分为实验组(维)、对照组(维)。实验组和对照组出现疼痛的患者均按照每次一粒,每日两次的服药剂量,分别服用布洛芬缓释胶囊和安慰剂(淀粉胶囊)三天。医师与患者在整个实验过程中,对于分组和服药情况均不知情。利用可视化痛觉量表(visual analogue scale,VAS)记录患者术后6小时、12小时、24小时、48小时、72小时和1周的疼痛程度。结果:第一阶段(预实验),汉族患者共有6人发生E flare-up,发生率为20.0%,FUI均值为0.75;维吾尔族患者共有10人发生E flare-up,发生率为33.3%,FUI均值为2.00。维吾尔族患者E flare-up的发生率和FUI均显著高于汉族患者。第二阶段实验在时间分布上,根管治疗后疼痛多发生于24至48小时之间,维吾尔族患者根管治疗后疼痛的发生率和剧烈程度均更显著。结论:慢性根尖周炎一次法根管治疗后,维吾尔族患者术后疼痛发生率高于汉族患者;服用布洛芬后汉族患者的镇痛效果更明显。
[Abstract]:Objective: to observe the pain incidence and severity of chronic periapical periodontitis in Han and Uygur patients, and to compare the analgesic effect of ibuprofen after root canal therapy among different nationalities. Methods: the clinical trial was divided into two stages. There were 28 patients with chronic periapical periodontitis in Uygur nationality aged from 16 to 39 years old and 2 patients aged between 40 and 59 years, including 11 males and 19 females. There were 27 Uygur patients between 16 and 39 years of age and 3 between 40 and 59 years of age, including 15 men and 15 women. Root canal therapy was performed with the method of crown down, and relevant data were recorded after treatment. The incidence of pain and acute attack index Flareindex-up (Flareindex-up) after root canal therapy in each group were analyzed. In the second stage, 250 patients with chronic periapical periodontitis of single root canal of Uygur nationality were randomly selected. According to the principle of random double blindness, the patients of Han nationality were divided into experimental group (Han) and control group (Han) after operation. Take ibuprofen sustained-release capsule and placebo (starch capsule) twice a day for three days. Visual analogue scale was used to record the pain degree of patients 6 hours, 12 hours, 48 hours, 48 hours, 72 hours and 1 week after operation. Results: the first stage (pre-experiment, Han nationality). There were 6 cases of E flare-up. the incidence rate of E flare-upwas 20.0% and the mean value of E flare-upis was 0.75 in 10 Uygur patients, and the incidence rate of E flare-upwas 3.33%. The incidence of E flare-up and FUI in Uygur patients were significantly higher than those in the second stage of Uygur patients. In the time distribution of the experiment, The incidence and severity of pain after root canal therapy in Uygur patients were more significant. Conclusion: after the treatment of chronic periapical periodontitis, the incidence and severity of pain in Uygur patients were higher than those in Uygur patients. Conclusion: the incidence and severity of pain after root canal therapy are more significant in Uygur patients. The incidence of postoperative pain in Uygur patients was higher than that in Han patients, and the analgesic effect of ibuprofen was more obvious.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R781.05

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