新疆地区汉族、维吾尔族帕金森病患者中血清免疫球蛋白、补体水平的临床研究

发布时间：2018-03-08 12:24

本文选题：帕金森病　切入点：IgG　出处：《新疆医科大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:研究新疆汉族、维吾尔族帕金森病(PD)患者血清中免疫球蛋白(IgG、IgA、IgM)及补体(C3、C4)水平是否具有差异。方法选择104例原发性帕金森病患者(PD组),其中汉族64例,维吾尔族40例;选择135例健康体检者为对照组,其中汉族84例,维吾尔族51例。采用特种蛋白分析仪检测血清中免疫球蛋白(IgG、IgA、IgM)及补体(C3、C4)的水平,分析汉族、维吾尔族PD患者的血清免疫球蛋白(IgG、IgA、IgM)、补体水平(C3、C4)是否存在差异及其与PD的关系。结果:PD组IgG值高于对照组(P0.05)。维吾尔族PD组IgA值高于维吾尔族对照组(P0.05)。汉族PD组与汉族对照组IgG、IgA、IgM、C3、C4值差异均无统计学意义(P0.05),汉族PD与维族PD组各指标差异也无统计学意义(P0.05)。将与总体PD相关的五个因素(Ig G、IgA、IgM、C3、C4)进行Logistic回归分析提示,血清IgG每增加1个单位,PD的发生风险增加1.675倍(P=0.007,OR=1.675)。进一步将与汉族PD相关的5个因素(IgG、IgA、IgM、C3、C4)进行Logistic回归分析提示,汉族血清IgG每增加1个单位,汉族PD的发生风险增加2.096倍(P=0.029,OR=2.096)。但血清Ig G水平与维族PD无关。结论:PD患者IgG值高于正常人;维吾尔族PD患者IgA值高于正常维吾尔族人;汉族组中IgG升高可能增加PD发病的危险性。
[Abstract]:Objective: to study the difference of serum immunoglobulin (IgG) and complement C _ (3) (C _ (4)) in PD patients of Han nationality and Uygur nationality in Xinjiang. Methods: 104 cases of PD patients with primary Parkinson's disease were selected, including 64 cases of Han nationality and 40 cases of Uygur nationality. 135 healthy persons were selected as control group, including 84 Han nationality and 51 Uygur nationality. Whether there were differences in serum immunoglobulin (IgG) and complement level (C _ 3C _ 4) and their relationship with PD in Uygur patients with PD. Results the IgG value in the group of 10% PD was higher than that in the control group (P 0.05). The value of IgA in the group of Uygur PD was higher than that in the control group (P 0.05), and the value of IgA in the group of PD of Han nationality was higher than that of the control group (P 0.05). There was no significant difference in C _ 3C _ 3 C _ 4 between the two groups, and there was no significant difference in all indexes between PD and Uygur group (P < 0.05). The Logistic regression analysis showed that the five factors related to the total PD were Ig GG IgAU IgMU C _ 3C _ 4, and that there was no significant difference between the two groups (P < 0.05), and there was no significant difference between the two groups (P < 0.05), and there was no significant difference between the two groups (P < 0.05). The risk of serum IgG increased by 1.675 times per unit of PD. The Logistic regression analysis of 5 factors related to PD in Han nationality showed that the serum IgG of Han nationality was increased by 1 unit. The risk of PD in Han nationality was increased by 2.096 times, but the level of serum IgG was not correlated with Uygur PD. Conclusion the IgG value of the patients with PD at 20% is higher than that of the normal people, the IgA value of the patients with PD in Uygur is higher than that of the normal Uygur. Increased IgG may increase the risk of PD in Han nationality.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R742.5

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