柴夏牡蛎汤治疗良性单纯性甲状腺结节（气郁痰阻型）的临床疗效观察

发布时间：2018-03-10 04:13

本文选题：良性单纯性甲状腺结节　切入点：瘿病　出处：《黑龙江中医药大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:探究柴夏牡蛎汤治疗良性单纯性甲状腺结节患者甲状腺结节的临床疗效,并验证其安全性。方法:根据随机数字表法,将符合纳入标准的68例患者随机分为两组,柴夏牡蛎汤组和夏枯草颗粒组,每组34例,柴夏牡蛎汤组给予柴夏牡蛎汤,1剂/日,口服;夏枯草颗粒组给予夏枯草颗粒,1袋/次,2次/日,口服;同时配合基础治疗,共治疗3个月,治疗结束后观察两组患者的甲状腺最大结节大小(直径)、数目及中医证候分级量化表的影响。利用SPSS17.0统计学软件对数据结果进行处理和分析。结果:1.甲状腺最大结节大小(直径)方面:柴夏牡蛎汤组治疗前后,有极显著性差异(p0.01),夏枯草颗粒组治疗后与治疗前相比,有显著性差异(P0.05);治疗后柴夏牡蛎汤组与夏枯草颗粒组相比,有极显著性差异(P0.01)。2.甲状腺结节数目方面:柴夏牡蛎汤组治疗前后,无显著性差异(p0.05),夏枯草颗粒组治疗后与治疗前相比,无显著性差异(p0.05);治疗后柴夏牡蛎汤组与夏枯草颗粒组相比,无显著性差异(p0.05)。3.在中医症候积分方面:柴夏牡蛎汤组治疗前后,有极显著性差异(p0.01),夏枯草颗粒组治疗后与治疗前相比,有极显著性差异(P0.01);治疗后柴夏牡蛎汤组与夏枯草颗粒组相比,有极显著性差异(P0.01)。4.两组患者治疗前后甲状腺功能检查,无显著性差异(p0.05),患者服药后无恶心呕吐,腹泻,皮肤瘙痒等不良影响。结论1.柴夏牡蛎汤能缩小良性单纯性甲状腺结节患者的结节大小。2.柴夏牡蛎汤能显著改善良性单纯性甲状腺结节患者的中医证候。3.柴夏牡蛎汤不会引起患者的甲状腺功能的变化,且安全性好。
[Abstract]:Objective: to investigate the clinical efficacy and safety of Chaixia Oyster soup in the treatment of thyroid nodules in benign simple thyroid nodules. Methods: according to the random digital table, 68 patients with benign thyroid nodules were randomly divided into two groups. In the Chaixia Oyster soup group and the Prunus subtilis granule group, 34 cases in each group, the Chaixia Oyster soup group was given 1 dose per day of Chaixia Oyster soup, and the Prunella subtilis granule group was given 1 bag / twice a day for oral use; at the same time, it was treated with basic treatment. For a total of 3 months, After the treatment, we observed the influence of the largest thyroid nodule size (diameters, numbers and TCM syndromes grading) in the two groups. The data were processed and analyzed by SPSS17.0 software. Results: 1. The thyroid gland was the largest. Nodule size (diameter): before and after treatment in the Chaixia Oyster soup group, There was a significant difference between the two groups after treatment (P 0.05), and after treatment, there was a significant difference between the two groups (P 0.05), and after the treatment, there was a significant difference between the two groups. There was significant difference in the number of thyroid nodules: there was no significant difference in the number of thyroid nodules before and after treatment in the Chaixia Oyster soup group, and there was no significant difference between the two groups before and after treatment (P 0.05), and there was no significant difference in the number of thyroid nodules between the two groups after treatment. After treatment, there was no significant difference between the Chaixia Oyster soup group and the Prunus subtilis granule group. There was no significant difference in the score of TCM symptoms: before and after treatment, there was no significant difference between the Chaixia Oyster soup group and the Prunus subtilis granule group. There was a significant difference between the two groups after treatment (P 0.01), after treatment, there was a significant difference between the two groups (P 0.01), and after treatment, there was a significant difference between the Chaixia Oyster soup group and the Prunella granulosa group (P 0.01). 4. Before and after treatment, the thyroid function of the patients in the two groups was examined, and compared with that before and after treatment, there was a significant difference between the two groups. There was no significant difference (P 0.05). There was no nausea, vomiting and diarrhea after taking medicine. Conclusion 1. Chai Xia Oyster soup can reduce the nodule size of benign simple thyroid nodule patients. 2. Chai Xia Oyster soup can significantly improve the TCM syndrome of benign simple thyroid nodule patients. 2. Chaixia Oyster soup can significantly improve the TCM syndrome of benign simple thyroid nodule patients. 3. Chaixia Oyster soup can reduce the nodule size of benign simple thyroid nodule patients. Oyster soup does not cause changes in the thyroid function of patients, And the safety is good.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259

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