维、汉民族胃癌临床病理特征和EGFR、VEGF在胃癌组织中的表达及意义

发布时间：2018-03-10 22:01

本文选题：胃癌　切入点：临床病理特征　出处：《新疆医科大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:探讨新疆维吾尔族和汉族胃癌临床病理特征,并分析EGFR和VEGF在胃癌组织中的表达及与临床病理特征的关系以及二者的相关性,为疾病的评估和诊治提供帮助。方法:以2011年1月至2015年12月在我院行手术治疗的592例胃癌患者为研究对象,对其一般资料及临床病理等相关资料进行回顾性分析。采用免疫组化SP方法,检测其中230例胃癌组织中EGFR和VEGF的表达,并分析其与临床病理参数的关系及二者相关性。结果:592例胃癌中,维吾尔族胃癌164例,男女比为3.69:1,汉族428例,男女比为2.92:1,好发年龄均为51~70岁。维吾尔族胃癌肿瘤部位较汉族相比位置偏上(P0.05)。两民族胃癌病理组织学类型均以腺癌居多,进展期胃癌大体类型以BorrmannⅡ型为主。维吾尔族早期胃癌6例(3.7%),汉族49例(11.4%),与汉族相比维吾尔族早期胃癌所占比例偏少(P0.05)。维吾尔族胃癌T分期及TNM分期较汉族偏高(P0.05)。EGFR在胃癌组织中的阳性表达率为23.0%(53/230),VEGF的阳性表达率18.3%(42/230)。EGFR表达与淋巴结转移密切相关(P0.05),而与肿瘤部位、大小、分化程度、浸润深度、TNM分期及有无癌栓无关。VEGF与肿瘤分化程度、浸润深度、淋巴结转移及TMN分期密切相关(P0.05)。且二者表达呈相关性(P0.05)。结论:维吾尔族和汉族胃癌在临床病理学特征上既有相同点也有不同点,应采取相应的诊疗措施。EGFR和VEGF的表达在胃癌的发生、发展中起重要作用,二者表达呈相关性,为胃癌的靶向治疗提供依据。
[Abstract]:Objective: To investigate the Xinjiang Uygur and Han the clinicopathological features of gastric carcinoma, and to analyze the correlation between the expression of EGFR and VEGF in gastric carcinoma and its relationship with clinical pathological features and the two, to provide help for the assessment and diagnosis and treatment of the disease. Methods: from January 2011 to December 2015 in 592 cases of gastric cancer patients in our hospital underwent surgery for research the object, the general data and clinical pathological data were retrospectively analyzed. Using immunohistochemical SP method, the expression of EGFR and VEGF were detected in 230 cases of gastric carcinoma, and analyze its relationship with clinical pathological parameters and the correlation between the two. Results: 592 cases of gastric cancer, 164 cases of gastric cancer in Uygur men and women. Ratio of 3.69:1, 428 cases of Han nationality, male and female ratio of 2.92:1, good hair age 51~70. In gastric tumor site than the Han side compared to the location (P0.05). The two national pathology of gastric cancer histological types were In the most general types of adenocarcinoma, advanced gastric cancer with Borrmann II type. In 6 cases of early gastric cancer (3.7%), 49 cases of Han (11.4%), compared with Han Uygur proportion of early gastric cancer (P0.05). The less the T staging of gastric cancer and TNM staging than the Han high (P0.05) positive expression of.EGFR in gastric cancer tissues was 23% (53/230), the positive expression rate of VEGF was 18.3% (42/230) expression of.EGFR correlated with lymph node metastasis (P0.05), and the tumor size, degree of differentiation, depth of invasion, TNM staging and tumor thrombus.VEGF is not associated with the degree of tumor differentiation, invasion depth, lymph node metastasis and TMN staging are closely related (P0.05). And the two expression correlated (P0.05). Conclusion: the Uygur and Han in gastric cancer clinical and pathological features of both the same, should take corresponding treatment measures of.EGFR and the expression of VEGF in gastric cancer. Birth and development play an important role. The expression of the two is related, which provides a basis for the target treatment of gastric cancer.

【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R735.2

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