血清胆红素水平与择期PCI围手术期心肌损伤相关性的回顾性分析研究

发布时间：2018-03-12 18:44

  本文选题：胆红素　切入点：PCI　出处：《浙江大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:通过回顾性研究分析接受择期经皮冠脉介入治疗(percutaneous coronary intervention,PCI)患者术前血清胆红素水平与围手术期心肌损伤(periprocedural myocardial injury,PMI)的相关性。方法:本研究回顾性分析行择期PCI术的2356例连续病例,收集PCI术后8、16、24小时血清肌钙蛋白Ⅰ和CKMB峰值,以及PCI术前血清胆红素数据,终点事件为PMI(定义为PCI术后24小时内肌钙蛋白Ⅰ或CKMB峰值≥5倍参考值上限),通过logistic回归分析并探讨术前血清胆红素水平和围手术期心肌损伤的相关性。结果:两组间比较,PMI组患者术前胆红素水平低于非PMI组(13.2 vs14.1μmol/L,p=0.019)。经过多因素logistic回归分析提示术前高水平胆红素组(胆红素15.3μmol/L)患者与低水平胆红素组(胆红素10.6μmol/L)患者相比,术后PMI的发生风险较低(OR:0.699,95%CI:0.531-0.921,p=0.011)。结论:择期PCI术前血清胆红素水平与PMI的发生风险相关,较高的血清胆红素水平可以降低术后PMI的发生率。
[Abstract]:Objective: to analyze the correlation between preoperative bilirubin level and perioperative perioperative myocardial injury myocardial injury-PMIs in patients undergoing percutaneous coronary intervention (PCI) with percutaneous coronary intervention (PCI). Methods: PCI was performed retrospectively in this study. Of 2356 consecutive cases of surgery, The peak values of serum troponin I and CKMB and serum bilirubin before PCI were collected at 816 hours after PCI. The endpoint event was PMI (defined as troponin I or CKMB peak value 鈮，

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