任脉穴位贴敷联合翁沥通胶囊治疗良性前列腺增生症临床研究

发布时间：2018-03-14 04:15

本文选题：良性前列腺增生　切入点：穴位贴敷　出处：《北京中医药大学》2017年硕士论文　论文类型：学位论文

【摘要】：良性前列腺增生症(BPH)是老年男性的一种常见病,临床主要表现是尿频、尿急、夜尿增多、排尿困难等,严重影响了老年患者的生活质量。目前前列腺增生症的治疗主要包括药物治疗和手术治疗,而前列腺增生常发生于老年人群,很多患者年龄大、体力衰弱或合并有严重的心肺疾患,难以耐受手术创伤,而长期单独药物治疗难以奏效,张耀圣教授通过多年临床实践,提出前列腺疾病"分经论治"的新理论,认为其中前列腺增生与任脉相关,病理以阴质结聚、阳气虚弱为主,前期根据此理论进行的中药内服临床试验取得很好的效果,本次研究是在此理论的基础上进行的一次外治法的研究,即选择任脉穴位进行外治贴敷,其具有简便易行、易为患者接受、无痛、毒副作用少、患者依从性好等特点,在临床中发挥出优势,值得进一步的研究和推广。目的:本次研究通过任脉穴位贴敷联合翁沥通胶囊治疗良性前列腺增生症,并观察患者IPSS评分、生活质量评分、中医证候评分的变化,客观评价任脉穴位贴敷的临床有效性以及安全性。方法:采用随机、对照的临床研究方法,选取良性前列腺增生症(痰瘀互阻型)患者40例,随机分为对照组和治疗组,对照组服用翁沥通胶囊,3粒/次,2次/日。治疗组在服用翁沥通胶囊基础上配合任脉穴位贴敷,贴敷为1次/日。2周为一个疗程,共观察2个疗程,即4周。4周后,观察两组治疗前后患者国际前列腺症状评分、排尿症状对生活质量的影响、中医症状评分。所有的结果采用SPSS20.0软件进行统计分析,P0.05表示差异有统计学意义。结果:治疗两个疗程后,治疗组总有效率为85%,对照组总有效率为70%,两者对比治疗组优于对照组(P0.05)。两组在国际前列腺症状评分(I-PSS)、排尿症状对生活质量(QOL)的影响以及中医证状评分方面均较治疗前有明显改善,在I-PSS和QOL方面治疗组优于对照组,差异有统计学意义(P0.05)。结论:服用翁沥通胶囊可以改善良性前列腺增生患者的临床症状,降低国际前列腺症状评分,提高生活质量,而配合任脉穴位贴敷则能够更明显改善良性前列腺增生患者的临床症状、降低IPSS评分,各方面相比要优于对照组。因观察时间短而且前列腺体积与临床症状无明显相关性,所以未对前列腺体积变化做进一步统计。本次研究结果验证了任脉穴位贴敷对良性前列腺增生症患者有效性,并且因其临床的安全性以及廉价、易操作的临床特点也便于进一步的推广应用,而且又验证了张耀圣教授"前列腺经络归属"的新理论,为下一步进行大规模的临床研究以及动物实验研究打下基础。
[Abstract]:Benign Prostate Hyperplasia (BPH) is a common disease in elderly men. The main clinical manifestations are frequent urination, urgency, increased nocturnal urine, difficulty in urinating, etc. This has seriously affected the quality of life of elderly patients. At present, the treatment of benign prostatic hyperplasia mainly includes drug therapy and surgical treatment, and prostatic hyperplasia often occurs in the elderly, many of whom are older. Physical weakness or severe cardiopulmonary diseases make it difficult to withstand surgical trauma, while long-term drug therapy alone is difficult to work. Professor Zhang Yao-sheng has put forward a new theory of "treating prostate diseases by dividing the meridians and treating them" through many years of clinical practice. It is considered that prostatic hyperplasia is related to any pulse, and the pathology is mainly due to the accumulation of yin and deficiency of yang qi. The clinical trial of Chinese herbal medicine on the basis of this theory in the early stage has achieved very good results. This study is based on this theory of a study of external treatment, that is, choose any pulse point to apply external treatment, its easy to be easily accepted, painless, less toxic and side effects, good compliance of patients, and so on. It is worth further research and popularization in clinical practice. Objective: this study treated benign prostatic hyperplasia with Ren Mai acupoint application and Weng Leitong capsule, and observed the patients' IPSS score and quality of life score. The change of TCM syndrome score, objective evaluation of clinical efficacy and safety of acupoint application of Ren vein. Methods: 40 patients with benign prostatic hyperplasia (phlegm and blood stasis mutual obstruction) were selected by randomized and controlled clinical study. The control group was randomly divided into control group and treatment group. The control group took 3 capsules of Weng Leitong capsule twice a day. The treatment group was treated with Zengmai acupoint application on the basis of Weng Leitong capsule, and the treatment group was applied once a day for 2 weeks as a course of treatment, and 2 courses of treatment were observed. After 4 weeks, 4 weeks later, the international prostate symptom scores and the effect of urination symptoms on the quality of life were observed before and after treatment in the two groups. Scores of TCM symptoms. All the results were statistically analyzed by SPSS20.0 software. Results: after two courses of treatment, the difference was statistically significant. The total effective rate of the treatment group was 85 and the total effective rate of the control group was 70. The treatment group was superior to the control group in P0.05. Both groups were better than the control group in the international prostate symptom score (I-PSSN), the effect of urination symptoms on the quality of life (QOL) and the TCM syndromes score. There was a marked improvement before the treatment. The treatment group was superior to the control group in I-PSS and QOL, and the difference was statistically significant (P 0.05). Conclusion: Weng Li Tong capsule can improve the clinical symptoms of patients with benign prostatic hyperplasia, reduce the international prostate symptom score, and improve the quality of life. The clinical symptoms of patients with benign prostatic hyperplasia can be improved more obviously and the IPSS score can be reduced with the application of acupoint application of Ren Mai, which is better than that of the control group in all aspects. Because the observation time is short and the volume of prostate has no obvious correlation with clinical symptoms, Therefore, no further statistics were made on the changes of prostate volume. The results of this study confirmed the effectiveness of Ren Mai acupoint application in patients with benign prostatic hyperplasia, and because of its clinical safety and low cost, The easy-to-operate clinical features are also convenient for further popularization and application, and the new theory of Professor Zhang Yao-sheng 's "the attribution of the prostate meridian" is verified, which lays the foundation for the next large-scale clinical research and animal experimental research.
【学位授予单位】：北京中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R277.5

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