中医药干预糖尿病患者便秘的临床研究

发布时间：2018-03-22 13:09

本文选题：中医　切入点：辨证论治　出处：《南京中医药大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:观察中医药辨证施治对糖尿病便秘患者的临床疗效,及对患者血糖的影响。方法:将80例符合糖尿病便秘诊断标准的患者,按照随机对照的原则,分为治疗组40例和对照组40例。治疗组采用基础治疗+中医药干预,对照组采用基础治疗+莫沙比利+大黄碳酸氢钠片。两组均以1个月为一个疗程,观察2个疗程,比较治疗前后两组患者的总体疗效、中医证候疗效、中医证候总积分、Bristol粪便质地分型、Wexner便秘评分、空腹血糖、糖化血红蛋白的改善情况。结果:临床研究表明:①总体疗效两组间比较差异不明显(P0.05),治疗组总有效率(95.00%)稍高于对照组(90.00%),表明两组总体疗效相当;②治疗组与对照组的中医证候总积分均较治疗前显著下降(P0.01),治疗组治疗后的中医证候总积分低于对照组(P0.05),中医证候疗效治疗组亦明显优于对照组(P0.01),治疗组总有效率(97.50%)亦高于对照组(85.00%);③Bristol粪便质地分型及Wexner便秘评分方面,两组治疗后均较治疗前明显改善(P0.01),但治疗后两组间比较差异均不明显(P0.05),表明两组在改善粪便质地及便秘症状方面效果相当;④空腹血糖及糖化血红蛋白方面,治疗组治疗后均较治疗前明显降低(P0.01),对照组治疗前后均无明显改善(P0.05),治疗后治疗组空腹血糖明显低于对照组(P0.01),糖化血红蛋白低于对照组(P0.05),表明在改善血糖方面治疗组效果优于对照组。结论中医辨证论治能够有效缓解糖尿病便秘患者的病情,改善其临床症状和粪便质地、降低血糖,具有标本同治的作用,尤其在起改善中医证候和降血糖方面效果优于莫沙必利、大黄碳酸氢纳片联合治疗。
[Abstract]:Objective: to observe the clinical effect of TCM syndrome differentiation and treatment on diabetic constipation patients and its effect on blood glucose. Methods: 80 patients who met the diagnostic criteria of diabetic constipation were divided into two groups according to the principle of randomized control. The treatment group was treated with traditional Chinese medicine, the control group was treated with moxapride rhubarb sodium bicarbonate tablet, and the two groups were treated with one month as a course of treatment and two courses of treatment. The total curative effect, syndromes of TCM, total integral of TCM syndromes, Bristol fecal texture typing and Wexner constipation score, fasting blood glucose were compared between the two groups before and after treatment. Results: the improvement of glycosylated hemoglobin. Results: the clinical study showed that there was no significant difference between the two groups in the overall curative effect of the two groups. The total effective rate of the treatment group was 95. 000.It was slightly higher than that of the control group, indicating that the overall curative effect of the two groups was equal to that of the control group. The total score of TCM syndromes in the treatment group was lower than that in the control group (P 0.05), the therapeutic effect of TCM syndrome in the treatment group was significantly better than that in the control group (P 0.01), and the total effective rate in the treatment group was also higher than that in the control group. 85.00 Bristol fecal texture typing and Wexner constipation score, The results showed that there was no significant difference between the two groups in improving fecal texture and constipation symptoms. 4 fasting blood glucose and glycosylated hemoglobin were significantly improved in the two groups after treatment, but there was no significant difference between the two groups after treatment, indicating that the two groups were effective in improving fecal texture and constipation symptoms. After treatment, the treatment group was significantly lower than that before and after treatment, while the control group had no significant improvement before and after treatment. After treatment, the fasting blood glucose in the treatment group was significantly lower than that in the control group, and the glycosylated hemoglobin was lower than that in the control group. Conclusion TCM treatment based on syndrome differentiation can effectively alleviate the condition of diabetic constipation patients. Improving its clinical symptoms and fecal texture, lowering blood sugar, it has the same effect of specimen treatment, especially in the improvement of TCM syndromes and hypoglycemic effect is better than mosapride, rhubarb bicarbonate tablet combined treatment.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259

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