大株红景天联合普罗布考对脑梗死疗效及相关因素影响的对照研究

发布时间：2018-03-26 20:32

本文选题：大株红景天注射液　切入点：普罗布考　出处：《河北医科大学》2017年硕士论文

【摘要】：目的:探究与分析大株红景天联合普罗布考治疗脑梗死的临床疗效及对相关因素的影响。方法:选取廊坊市人民医院自2015年3月至2015年12月收治的脑梗死患者120例,采取随机数字表法分为A、B、C三组,每组各40例,三组患者均给予健康教育、饮食指导、适量运动,平稳控制基础疾病等治疗,在保证治疗质量的前提下,A组给予常规治疗:包括抗血小板聚集、降血脂、降血压、降血糖、扩张冠状动脉等治疗,并酌情使用脱水剂。B组给予常规治疗+大株红景天注射液。C组给予常规治疗+大株红景天注射液+普罗布考。观察指标包括:(1)治疗前后脑梗死患者美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)、日常生活能力指数评估量表(Barthel Index,BI)、改良Rankin量表(Modified Rankin Scale,MRS)、吞咽功能障碍分级量表(洼田饮水试验分级)、简易精神状态检查表(Minimum Mental State Examination,MMSE)变化。(2)治疗前后颈动脉斑块的大小、厚度变化。(3)血脂指标:总胆固醇(total cholesterol,TC)、甘油三脂(Triglyceride,TG)、高密度脂蛋白(high density lipoprotein,HDL)、低密度脂蛋白(low densith lipoprotein,LDL)变化。(4)C反应蛋白(C-reactive protein,CRP)、扩血管物质降钙素基因相关肽(Calcitonin gene-related peptide,CGRP)、同型半胱氨酸(homocystine,Hcy)变化。(5)肝肾功能、心功能、心肌酶变化及心电图变化。并通过SPSS19.0进行统计,所得到的结果再利用t进行检验,对每个变量之间所存在的差异进行统计,观察有无统计学意义?结果:三组治疗后与治疗前相比NHISS评分、MRS评分均显著降低,BI指数、洼田饮水试验分级、MMSE评分均显著增高,颈动脉斑块大小、厚度均减小,TC、TG及LDL-C均降低,HDL-C升高,C组治疗后与B组治疗后、CRP、CGRP及Hcy均降低,差异有统计学意义。与A组治疗后相比,B、C组治疗后NHISS评分、MRS评分均显著降低,BI指数、洼田饮水试验分级、MMSE评分均显著增高,颈动脉斑块大小、厚度均减小,TC、TG及LDL-C均降低,HDL-C升高,CRP、CGRP及Hcy均降低,差异有统计学意义。C组治疗后与A、B组治疗后相比NHISS评分、MRS评分均显著降低,BI指数、洼田饮水试验分级、MMSE评分均显著增高,颈动脉斑块大小、厚度均减小,TC、TG及LDL-C均降低,HDL-C升高,CRP、CGRP及Hcy均降低,差异有统计学意义,(P0.05)。三组患者行肝、肾功能、心功能、心肌酶变化及心电图变化等检查均未见异常。结论:大株红景天联合普罗布考治疗脑梗死的临床疗效突出,可明显缓解病情,改善异常指标,安全有效。
[Abstract]:Objective: to investigate and analyze the clinical effect of Rhizoma Rhodiola and Probucol in the treatment of cerebral infarction. Methods: 120 patients with cerebral infarction treated in Langfang people's Hospital from March 2015 to December 2015 were selected. Patients in each group were given health education, diet guidance, moderate exercise, stable control of basic diseases, and so on, and were divided into three groups with 40 cases in each group by random digital table method, and the patients in each group were treated with health education, diet guidance, moderate exercise, stable control of basic diseases, and so on. Under the premise of ensuring the quality of treatment, group A was given routine treatment, including antiplatelet aggregation, lowering blood lipid, lowering blood pressure, lowering blood sugar, dilating coronary artery, etc. As appropriate, group B was given routine treatment with large strain of Rhodiola injection. C group was given routine treatment of probucol injection of large strain Rhodiola injection. The observed indexes include: 1) National Health of patients with Cerebral Infarction before and after treatment. The National Institute of Health stroke scale, the activity of Daily living Index (ADL), the modified Rankin scale (modified Rankin scale), the dysphagia scale (Wadi Water Test scale), the Minimum Mental State examination scale (MMSE), the modified Rankin scale (modified Rankin scale), the National Institute of Health stroke scale (NIH), the modified Rankin scale (modified Rankin scale), the modified Rankin scale (modified Rankin scale), the modified Rankin scale (modified Rankin scale), the scale of dysphagia, the Minimum Mental State examination scale (MMSE). (2) carotid plaque size before and after treatment, Changes in blood lipids: total cholesterol cholesterol total cholesterol cholesterol total TCN, triglyceride-triglyceride TGG, high density lipoprotein high density protein HDLX, low density lipoprotein low densith lipoprotein change. C-reactive CRPN, calcitonin gene-related gene-related gene-related, homocysteine (HDL4), C-reactive protein (C-reactive protein), calcitonin gene-related peptidea (calcitonin gene-related peptidet), changes in serum lipids and blood lipids: total cholesterol: total cholesterol: total cholesterol; triglyceride; High density lipoprotein; low density lipoprotein; low density lipoprotein; C-reactive protein; calcitonin gene-related peptide; calcitonin gene-related gene-related; Hcy5) liver and kidney function, Cardiac function, myocardial enzyme changes and electrocardiogram changes. And through SPSS19.0 statistics, the results obtained by t test, the differences between each variable for statistical observation, there is no statistical significance? Results: after treatment, the NHISS scores and Mrs scores in the three groups were significantly lower than those before treatment, and the scores of Wata drinking water test were significantly higher than those before treatment, and the carotid plaque size was significantly increased. The thickness of TG and LDL-C decreased significantly after treatment in group C and group B, the NHISS scores and Mrs scores in group C were significantly lower than those in group A, and the scores of NHISS and Mrs in group C were significantly lower than those in group B after treatment, and there was a significant difference between group C and group B after treatment, and the scores of NHISS and Mrs in group C were significantly lower than those in group A, and the scores of NHISS and Mrs in group C were significantly lower than those in group A. The scores of MMSE were significantly increased, carotid plaque size and thickness were decreased, HDL-C was increased and Hcy and CGRP were decreased. The difference was statistically significant. The NHISS scores and Mrs scores in group C were significantly lower than those in group A B after treatment. The scores of NHISS scores and carotid plaques were significantly higher in group C than in group B, and the scores of Wadi drinking water test were significantly higher than those in group A and B, and the size of carotid plaques was significantly increased in group C. The thickness of TG and LDL-C were all decreased, HDL-C was increased, CGRP and Hcy were decreased, the difference was statistically significant (P 0.05). The three groups were given liver, renal function and cardiac function. Conclusion: the clinical effect of RDRC combined with Probucol in the treatment of cerebral infarction is obvious, which can obviously alleviate the condition, improve the abnormal index, and be safe and effective.
【学位授予单位】：河北医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R743.3

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