泻肝安神汤加减方治疗老年性皮肤瘙痒症临床观察

发布时间：2018-03-27 11:16

本文选题：皮肤瘙痒症　切入点：老年性　出处：《新疆医科大学》2017年硕士论文

【摘要】：目的:采用泻肝安神汤加减方治疗肝旺脾虚型老年性皮肤瘙痒症,通过临床疗效的观察,客观评价泻肝安神汤加减方治疗老年性皮肤瘙痒症(肝旺脾虚型)的临床疗效,并探讨其疗效机理,旨在为老年性皮肤瘙痒症的中医辨证论治提供理论依据。方法:将135例符合纳入标准的老年性皮肤瘙痒症患者,分为两组:治疗组68例,对照组67例。两组均予以基础治疗:保湿剂外擦,治疗组口服泻肝安神汤加减方,对照组口服依巴斯汀片,两组均治疗4周。治疗结束时和治疗结束后1月各随访1次,研究结束。结果:治疗组66例完成试验,对照组66例完成试验,两组患者在性别、年龄、病程等方面经统计学处理无明显差异(P0.05),具有可比性。临床疗效比较:治疗组:治愈1例,显效11例,有效46例,无效8例,复发8例,总有效率87.88%,复发率12.12%,对照组:治愈0例,显效1例,有效34例,无效31例,复发19例,总有效率53.03%,复发率28.79%,两组总有效率相比,P0.05,表明两组疗效指数差异具有统计学意义。不良反应比较:两组患者在治疗过程中未出现头昏、呕吐、腹泻、嗜睡等不良反应。结论:泻肝安神汤加减方治疗肝旺脾虚型老年性皮肤瘙痒症疗效显著,肝旺脾虚是老年性皮肤瘙痒症的病机之一,为老年性皮肤瘙痒症的中医辨证论治提供了一定的理论依据。
[Abstract]:Objective: to use Xiegan Anshen decoction to treat senile skin pruritus with deficiency of liver and spleen, and to evaluate objectively the clinical effect of Xigan Anshen decoction on senile skin pruritus. The aim of this study was to provide a theoretical basis for the treatment of senile pruritus by differentiation of symptoms and signs. Methods: 135 patients with senile pruritus were divided into two groups: treatment group (n = 68), treatment group (n = 68), and treatment group (n = 68). 67 cases in the control group were treated with basic treatment: external rubbing of moisturizer, oral decoction of Xiegan Anshen decoction in the treatment group and Ebastine tablet in the control group. The two groups were treated for 4 weeks. Each group was followed up once at the end of the treatment and one month after the end of the treatment. Results: 66 patients in the treatment group and 66 patients in the control group completed the test. Comparison of clinical efficacy: 1 case was cured, 11 cases were markedly effective, 46 cases were effective, 8 cases were ineffective, 8 cases were relapse, the total effective rate was 87.88%, and the recurrence rate was 12.12%. In the control group, 0 cases were cured. There were significant effects in 1 case, effective in 34 cases, ineffective in 31 cases, recurrence in 19 cases. The total effective rate was 53.03 and the recurrence rate was 28.79. The total effective rate in the two groups was higher than that in the control group (P 0.05), which indicated that the difference of curative effect index between the two groups was statistically significant. Conclusion: Xiegan Anshen decoction is effective in treating senile skin pruritus with liver and spleen deficiency, which is one of the pathogenesis of senile pruritus. It provides a theoretical basis for the treatment of senile pruritus based on syndrome differentiation.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R275.9

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