健康人群面颈部皮肤生理学与VISIA成像学特征分析

发布时间：2018-03-28 03:25

  本文选题：皮肤生理　切入点：面部成像　出处：《安徽医科大学》2017年硕士论文

【摘要】：研究背景皮肤具有特殊的屏障作用,可抵御外界化学和物理因素的刺激,维持机体内环境的稳定,还具有保湿作用,防止过多水分的流失,保持角质层的含水量,调节肌肤的水分含量。通过定量测量面颈部皮肤生理特性和成像特征,分析相关参数及其关系,能够客观地评估皮肤年轻化、衰老速度及敏感程度。研究目的通过无创性功效学评价技术量化检测中国正常人群面颈部皮肤生理学特性和成像特征,分析其与性别、年龄的关系。研究方法将500名健康志愿者分为6个不同年龄组,利用无创性皮肤生理检测仪对其面颈部(前额、面颊、鼻尖及颈部)进行SC含水量、皮脂含量、TEWL、皮肤色素含量的测量,并采用VISIA面部成像系统对其中450名健康人面部皮肤的毛孔、紫质、皱纹、纹理、紫外线色斑等进行测量。研究结果不同年龄组间的TEWL值具有差异性(p0.05),鼻尖部高于前额部和面颊部,颈部TEWL值最低。女性的TEWL值低于男性(p0.05)。各年龄层SC含水量有差异性(p0.05),随年龄增加呈有统计学意义的下降(p0.05)。男性SC含水量低于女性,SC含水量也具有部位差异性,由高到低依次为颈部、前额、鼻尖、面颊部。皮脂含量受年龄和性别的影响,不同年龄组之间具有差异性(p0.05),16~25岁和26~35岁年龄组油脂含量最高。男性皮脂含量较同年龄组女性的高(p0.05)。鼻尖部和前额部油脂含量较高,其次为面颊、颈部。男性皮肤黑色素含量高于女性(p0.05),不同年龄组无组间差异性;女性黑色素含量随年龄增大而增多。面颈部血色素含量与年龄呈正相关(p0.05),男性血色素含量较女性高(p0.05)。皮肤表面pH值在面颊部最高,其次为前额、鼻尖、颈部。男性皮肤表面pH值较女性高;不同年龄组中,55~70岁年龄组皮肤表面pH值最高。面部紫外线色斑、皱纹以及纹理与年龄呈正性相关(p0.05),在相同年龄组中,男性高于女性。面部紫质分值与毛孔大小呈正相关。不同参数之间存在相关性,pH值与TEWL值在前额、面颊和颈部呈正相关。TEWL值与SC含水量在面颊、颈部及前额部呈正性相关。女性前额部皱纹分值与TEWL值呈正相关,紫外线色斑分值与SC含水量呈负相关。研究结论健康人群面颈部皮肤生理学及成像参数存在不同程度的差异性,并证实了各参数之间的相关性。另外,本研究首次结合VISIA面部成像特征,不仅能够更准确地指导护肤,而且也能更充分地评估皮肤年轻化。
[Abstract]:Background the skin has the special barrier function, can resist the external chemical and physical stimulation, maintain the stability of the body's environment, also has the function of moisturizing, preventing the excessive moisture loss, maintaining the water content of the cuticle, Adjust skin moisture content. Through quantitative measurement of skin physiological characteristics and imaging characteristics of face and neck skin, analysis of related parameters and their relationships, can objectively evaluate skin rejuvenation, Objective to study the physiological and imaging characteristics of facial and neck skin in Chinese normal population by non-invasive efficacy evaluation technique. Methods 500 healthy volunteers were divided into 6 age groups, and their face and neck (forehead, cheek, nose and neck) were measured with non-invasive skin physiological detector for SC water content. VISIA facial imaging system was used to measure the pores, purple, wrinkles, textures of the skin of 450 healthy people. The results showed that the TEWL values of different age groups were different (p0.05), and the nasal tip was higher than the forehead and cheek. The cervical TEWL value was the lowest. The TEWL value of the female was lower than that of the male. The water content of SC in all age groups was different (p0.05), and it decreased significantly with the increase of age. The water content of male SC was lower than that of female SC. The order from high to low is neck, forehead, nose tip, cheek. Sebum content is affected by age and sex. There was significant difference between different age groups (p 0.05). The highest oil content was found in the 25 and 2635 age groups. The sebum content in males was higher than that in females of the same age group (P 0.05). The fat content in nose tip and forehead was higher than that in cheek. Neck. The content of melanin in male skin was higher than that in female, and there was no difference among different age groups. The content of melanin in the face and neck was positively correlated with age, and the content of hemoglobin in male was higher than that in female. The pH value of skin surface was the highest in cheek, followed by forehead and nose tip. Neck. Male skin surface pH value is higher than that of female group; in different age group, 557 years old group has the highest skin surface pH value, and face ultraviolet spot, wrinkle and texture have positive correlation with age (p 0.05), in the same age group, There was a positive correlation between facial purple score and pore size. There was a positive correlation between pH value and TEWL value in forehead, a positive correlation between cheek and neck value and SC water content in cheek. There was a positive correlation between neck and forehead, and a positive correlation between female forehead wrinkle score and TEWL. Ultraviolet speckle score was negatively correlated with SC water content. Conclusion there are differences in skin physiology and imaging parameters of face and neck in healthy people, and the correlation between these parameters is confirmed. For the first time, this study combined with VISIA facial imaging features can not only guide skin care more accurately, but also evaluate skin rejuvenation more fully.
【学位授予单位】：安徽医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R334.5

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