睡眠障碍伴焦虑抑郁状态的T2DM患者血糖及相关因素特点分析

发布时间：2018-03-29 03:22

本文选题：睡眠障碍　切入点：焦虑抑郁状态　出处：《青海大学》2017年硕士论文

【摘要】：【目的】了解睡眠障碍伴焦虑抑郁状态对2型糖尿病患者血糖及相关指标的影响。【对象与方法】随机抽取2015年12月-2016年12月期间在青海大学附属医院内分泌科住院的已确诊为T2DM的病人共400名(男152名,女248名),对选中的所有研究对象进行PSQI、SDS、SAS的问卷调查,据睡眠质量及焦虑抑郁状态的存在状况分四组,分别收集记录研究目标的Gender、Age、病程、Height、Weight、SBP、DBP、FPG、PBG、HbA1c、FINS、空腹C肽、胰岛素的使用等。并用公式计算BMI、HOMA-β,HOMA-ISI,HOMA-IR。统计学分析应用SPSS19.0完成。【结果】睡眠障碍伴T2DM组,焦虑抑郁状态伴T2DM组、睡眠障碍伴焦虑抑郁状态的T2DM组与单纯2型糖尿病组相比,FPG、PBG、HbA1c、空腹C肽皆升高(P0.05),HOMA-IR升高(P0.008),HOMA-ISI降低(P0.008)。睡眠障碍伴T2DM组,焦虑抑郁状态伴T2DM组、睡眠障碍伴焦虑抑郁状态的T2DM组三组间FPG、PBG、空腹C肽无明显差异(P0.05),HOMA-ISI、HOMA-IR无明显差异(P0.008)。睡眠障碍伴焦虑抑郁状态的T2DM组较睡眠障碍伴T2DM组、焦虑抑郁状态伴T2DM组糖化血红蛋白水平高(P0.05);单纯2型糖尿病,睡眠障碍伴T2DM组、焦虑抑郁状态伴T2DM组、睡眠障碍伴焦虑抑郁状态的T2DM组四组间胰岛素使用无明显差异(P0.05)。【结论】睡眠障碍、焦虑抑郁状态对2型糖尿病患者的FPG、PBG、HbA1c、空腹C肽、HOMA-IR,HOMA-ISI都有影响,使FPG、PBG、HbA1c、空腹C肽、HOMA-IR等升高,HOMA-ISI降低。且在2型糖尿病患者中,睡眠障碍合并焦虑抑郁状态比焦虑抑郁状态、睡眠障碍单独存在时糖化血红蛋白水平偏高。
[Abstract]:[objective] to investigate the effect of sleep disorder with anxiety and depression on blood glucose and related indexes in patients with type 2 diabetes mellitus. [objects and methods] randomly selected from December 2015 to December 2016 in Department of Endocrinology, affiliated Hospital of Qinghai University. A total of 400 patients (152 men) have been diagnosed with T2DM in the hospital. 248 female subjects were investigated by PSQI SDSSAS questionnaire. According to sleep quality and anxiety and depression status, the subjects were divided into four groups. The Gendern age, the course of disease, the HbA1cFINS, and the fasting C-peptide were collected and recorded respectively. The use of insulin and so on. To calculate the BMI-HOMA- 尾 -HOMA-ISI HOMA-IR.The statistical analysis was performed with SPSS19.0. [results] Sleep disorder with T2DM, anxiety and depression with T2DM, Compared with type 2 diabetes mellitus group, T2DM group with sleep disorder with anxiety and depression had higher fasting C-peptide (P 0.05) and HOMA-IR, lower HOMA-ISI (P 0.008), sleep disorder with T2DM, anxiety and depression with T2DM. There was no significant difference in fasting C-peptide between the three groups of T2DM with sleep disorder and anxiety and depression. There was no significant difference in fasting C-peptide between the three groups (P 0.05). There was no significant difference in HOMA-ISI HOMA-IR between the three groups. The T2DM group with sleep disorder with anxiety and depression was higher than the T2DM group with sleep disorder with T2DM. The level of glycosylated hemoglobin was high in T2DM group, type 2 diabetes mellitus, sleep disorder with T2DM group, anxiety and depression state with T2DM group. There was no significant difference in insulin use among the four groups of T2DM patients with sleep disorder and anxiety depression. [conclusion] Sleep disorder, anxiety and depression state have influence on PBGG HbA1c and fasting C-peptide HOMA-IRN HOMA-ISI in type 2 diabetic patients. The levels of HbA1c, HOMA-IR and HOMA-ISI were decreased in patients with type 2 diabetes mellitus, and the level of glycosylated hemoglobin in patients with type 2 diabetes mellitus was higher than that in patients with type 2 diabetes mellitus, and the level of glycosylated hemoglobin in patients with sleep disorder alone was higher than that in patients with type 2 diabetes mellitus.
【学位授予单位】：青海大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R740;R749;R587.1

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