血脂及FABP4与结直肠肿瘤的相关性研究

发布时间：2018-03-31 14:04

本文选题：结直肠肿瘤　切入点：血脂　出处：《南京中医药大学》2017年硕士论文

【摘要】：背景:结直肠癌是目前最常见消化道肿瘤之一,发病率在国内一直呈上升趋势,尽管近年来结直肠癌综合防治水平有所提高,但是各地不平衡,国内总平均5年生存率在27%左右,仍然有30-40%病人死于复发和转移,结果仍然不是十分理想。目的:研究脂类代谢与结直肠肿瘤的相关性,对提高结直肠肿瘤的早期诊断和治疗水平可能具有重要价值,能够在结直肠肿瘤的预防及形成过程中进行干预,以及对预后提供更多的治疗方法。方法:1、回顾性分析结直肠癌组、结直肠腺瘤组与对照组患者的血脂指标及组间差异。2、分别检测结直肠肠癌组、结直肠腺瘤组、对照组患者血清标本中脂肪细胞型脂肪酸结合蛋白(FABP4)浓度值及血脂相关指标,分析三组间差别。结果:1、回顾性分析结直肠癌组、结直肠腺瘤组与对照组相比,肿瘤两组载脂蛋白A1(ApoAI)均低于对照组,差别有统计学意义(P0.05);结直肠癌组脂蛋白a(Lp(a))水平高于对照组,差别有统计学意义(P0.05);结直肠腺瘤组高密度脂蛋白胆固醇(HDL-C)水平低于对照组,差别有统计学意义(P0.05)。2、三组间血清标本中FABP4水平比较,差别无统计学意义(P0.05);肿瘤两组ApoAI及低密度脂蛋白胆固醇(LDL-C)平均低于对照组,差别有统计学意义(P0.05);结直肠癌组Lp(a)水平高于对照组,差别有统计学意义(P0.05)。结论:结直肠肿瘤患者ApoAI较对照组有明显差别,结直肠癌患者Lp(a)较对照组有明显差别,说明肿瘤在发生及发展过程中与ApoAI、Lp(a)代谢有一定的关联,为今后结直肠癌的预防、诊断及治疗提供了帮助及新方向;而肿瘤患者FABP4与对照组相比无统计学差异,仍需进一步的探索。
[Abstract]:Background: colorectal cancer is one of the most common digestive tract tumors at present. The incidence of colorectal cancer has been on the rise in China. Although the level of comprehensive prevention and treatment of colorectal cancer has improved in recent years, it is unbalanced in different regions. The average 5-year survival rate in China is about 27%, and 30-40% of the patients still die from recurrence and metastasis, the results are still not ideal. Objective: to study the correlation between lipid metabolism and colorectal tumors. It may be of great value in improving the level of early diagnosis and treatment of colorectal neoplasms, and can intervene in the prevention and formation of colorectal tumors. And to provide more treatment methods for prognosis. Methods: 1. Retrospective analysis of serum lipids in colorectal cancer group, colorectal adenoma group and control group, and the difference between two groups, respectively, to detect colorectal cancer group, colorectal adenoma group, and colorectal adenoma group. The concentration of FABP4 in serum of the control group and the related indexes of blood lipids were analyzed, and the differences among the three groups were analyzed. Results: 1. The retrospective analysis of colorectal cancer group and colorectal adenoma group was compared with that of the control group. The level of apolipoprotein A1A1ApoAII in tumor group was significantly lower than that in control group (P 0.05), and the level of lipoprotein A (LpP) in colorectal cancer group was higher than that in control group (P 0.05), and the HDL-C level in colorectal adenoma group was lower than that in control group (P < 0 05), and the level of HDL-C in colorectal adenoma group was lower than that in control group (P < 0 05). There was no significant difference in serum FABP4 level among the three groups, and the ApoAI and LDL-C in tumor group were lower than those in control group. The difference was statistically significant (P 0.05), and the level of LpChina in colorectal cancer group was higher than that in control group (P 0.05). Conclusion: ApoAI in colorectal cancer patients is significantly higher than that in control group, and there is a significant difference between the patients with colorectal cancer and the control group. The results indicate that the tumor is related to the metabolism of ApoAI-LpChina in the course of its occurrence and development, which provides a new direction for the prevention, diagnosis and treatment of colorectal cancer, but there is no significant difference in FABP4 between the tumor patients and the control group. Further exploration is still needed.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R735.34

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