相关自身免疫疾病中血清IgG亚型分布特点研究

发布时间：2018-04-02 04:24

  本文选题：IgG亚型　切入点：类风湿关节炎　出处：《新疆医科大学》2017年硕士论文

【摘要】：目的:分析IgG亚型在相关自身免疫性疾病中的分布特点。方法:本研究共纳入自治区人民医院风湿免疫科2015-2016确诊类风湿关节炎患者160例、系统性红斑狼疮100例、强直性脊柱炎104例,原发性干燥综合征初治患者70例。所有患者均符合国际指南诊断标准。健康对照组患者50例。采用散射比浊法检测各受试者血清IgG1、IgG2、IgG3、IgG4水平;比较分析各种自身免疫性疾病患者血清IgG亚型水平与健康对照者有无差异,尤其是IgG4水平是否升高,并结合各自身免疫性疾病患者的临床资料,分析具有不同临床特征的患者IgG亚型分布特点及其相关性。结果:1.通过比较自身免疫性疾病患者与健康对照者血清IgG亚型发现:pSS患者血清IgGl、IgG3、总IgG水平显著高于对照组;RA患者血清IgGl、IgG3水平显著高于对照组;SLE患者血清IgGl、IgG3、总IgG水平显著高于对照组;AS患者血清血清IgGl、IgG4水平显著高于对照组。2.通过对各自身免疫性疾病患者血清IgG亚型进行相互比较发现:pSS组患者血清IgGl、总IgG水平显著高于其他各疾病组,AS组患者血清IgG2、IgG4水平显著高于其他各疾病组,RA组患者血清IgG3水平其他各疾病组。3.通过对各自身免疫性疾病不同亚组间患者血清IgG亚型进行比较发现:IgG亚型在具有不同临床特征患者中的分布有明显不同。pSS组患者中有抗SSA、SSB抗体阳性、ESR升高者其血清IgGl水平明显高于无上述特征者;RA组患者中继发肺间质纤维化患者其血清IgG4水平明显升高;SLE组患者中补体下降、ESR增快者血清IgGl水平显著升高,有肾受累者血清各IgG亚型均有显著下降,而且以IgG2降低更为明显;AS组患者中提示炎症反应的CRP、IL-6升高伴随IgG3增高。结论:1血清IgG亚型在pSS、RA、SLE、AS疾病患者中的分布明显不同于健康人群。2血清IgG亚型在pSS、RA、SLE、AS疾病患者间的分布有着显著区别。3血清IgG4水平与类风湿关节炎患者肺间质纤维化存在一定相关性。4血清IgG4水平在强直性脊柱炎患者中明显升高,可能与既往使用生物制剂相关。
[Abstract]:Objective: to analyze the distribution of IgG subtypes in autoimmune diseases. Methods: a total of 160 patients with rheumatoid arthritis and 100 patients with systemic lupus erythematosus were enrolled in this study. 104 cases of ankylosing spondylitis and 70 cases of primary Sjogren's syndrome. All the patients were in accordance with the international standard of diagnosis and 50 cases of healthy control group. To compare and analyze the difference of serum IgG subtype level between patients with various autoimmune diseases and healthy controls, especially whether the level of IgG4 increased, and combined with the clinical data of the patients with autoimmune diseases. The distribution and correlation of IgG subtypes in patients with different clinical characteristics were analyzed. Results: 1.Through comparing the serum IgG subtypes of patients with autoimmune diseases with those of healthy controls, we found that the total IgG level in patients with IgG was significantly higher than that in controls. The serum IgG3 level of RA patients was significantly higher than that of control group, and the total IgG level was significantly higher than that of control group. 2. The serum IgG subtypes of patients with autoimmune diseases were studied. It was found that the serum IgGland total IgG levels of the patients with PSS were significantly higher than those of the patients with as and other diseases. The serum IgG3 levels of the patients with RA were significantly higher than those of the patients with RA and other diseases. Comparison of serum IgG subtypes in patients with different subgroups of immunological diseases. The distribution of IgG subtypes in patients with different clinical characteristics was significantly different. The serum IgGl level of patients with elevated anti-SSA-SSB antibody was significantly higher in PSS group. The level of serum IgG4 in patients with secondary pulmonary interstitial fibrosis was significantly higher than that in RA patients without the above characteristics. Serum IgG subtypes were significantly decreased in patients with renal involvement. Moreover, the decrease of IgG2 was more obvious in as group than that in as group. Conclusion the distribution of serum IgG subtype pSS1 in patients with as disease is significantly different from that in healthy people. 2. Serum IgG subtype in patients with pSSRAA SLEAS disease is significantly different from that in healthy people. There was a significant correlation between serum IgG4 level and pulmonary interstitial fibrosis in patients with rheumatoid arthritis. The level of serum IgG4 in patients with ankylosing spondylitis was significantly higher than that in patients with ankylosing spondylitis. May be related to the past use of biological agents.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R593.2

【参考文献】

相关期刊论文 前1条

1 李萍;李永哲;;IgG亚类检测在相关疾病中的临床意义[J];中华检验医学杂志;2012年03期

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