胃癌患者术前后体脂CT定量及其对预后影响的回顾性分析

发布时间：2018-04-11 03:05

本文选题：胃癌 + CT　；参考：《广西医科大学》2017年硕士论文

【摘要】：目的:通过CT测量的腹部脂肪指标,以及BMI,以及年龄、性别、肿瘤直径、分期、分级等指标对胃癌根治术后总生存时间的影响,以探讨各种因素在胃癌术后生存率的主要影响作用。材料和方法:搜集2011年9月至2015年12月在广西医科大学第一附属医院因胃癌住院患者,并经胃大部切除术手术治疗病理证实为胃癌患者62例。术前资料采集包括患者的性别、年龄、BMI、肿瘤直径、肿瘤分期及分级,以及术前术后6个月CT腹部脂肪测量参数,包括TAT(腹部总体脂肪)、VAT(腹部内脏脂肪)、SAT(腹部皮下脂肪)。采用生存分析统计方法评价CT体脂参数与其他因素对胃癌手术患者预后和生存率的影响。结果:术后随访,TAT、VAT和SAT值均较术前显著下降(P0.001)。所有患者的中位生存期为337天(249-425天)。在单因素分析中,肿瘤分期、术前TAT和术前SAT与生存时间有关(P0.05),即肿瘤分期较低、术前TAT较高、术前SAT较高者,生存时间较长。生存时间与其他特征如年龄、性别、肿瘤大小、肿瘤分级、BMI和VAT无显著相关。进一步多因素分析(Cox回归分析)结果显示术前SAT为影响胃癌预后的相关因素(P0.05),即独立影响因素。结论:术前SAT可能是预测胃癌患者术后生存期的生物学指标。术前SAT较高者,生存时间较长。
[Abstract]:Objective: to evaluate the effect of abdominal fat index, BMI, age, sex, tumor diameter, stage, grade and so on on the total survival time after radical gastrectomy.To explore the main effect of various factors on survival rate after operation of gastric cancer.Materials and methods: from September 2011 to December 2015, 62 patients with gastric cancer were treated by subtotal gastrectomy in the first affiliated Hospital of Guangxi Medical University.The data collected before operation included sex, age, tumor diameter, tumor stage and grade, and abdominal fat measurement parameters of CT 6 months after operation, including TAT (abdominal visceral fat) (abdominal visceral fat) and SAT (abdominal subcutaneous fat).Survival analysis was used to evaluate the effects of CT body fat parameters and other factors on the prognosis and survival rate of patients with gastric cancer.Results: the values of VAT and SAT were significantly lower than those before operation (P 0.001).The median survival time for all patients was 337 days, 249 to 425 days.In univariate analysis, tumor staging, preoperative TAT and preoperative SAT were related to survival time (P 0.05), that is, tumor stage was lower, preoperative TAT was higher, preoperative SAT was higher, survival time was longer.There was no significant correlation between survival time and other characteristics such as age, sex, tumor size, tumor grade and VAT.The results of multivariate analysis and Cox regression analysis showed that preoperative SAT was an independent factor for the prognosis of gastric cancer.Conclusion: preoperative SAT may be a biological marker for predicting postoperative survival of patients with gastric cancer.The survival time of the patients with high preoperative SAT was longer.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R735.2

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