浅表性膀胱肿瘤术后表柔比星热灌注化疗效果观察

发布时间：2018-04-11 05:17

本文选题：浅表性膀胱肿瘤 + 表柔比星　；参考：《青海大学》2017年硕士论文

【摘要】：目的:本研究旨在通过对初发浅表性膀胱肿瘤患者TUR-BT术后给予表柔比星射频热疗机下热灌注化疗与目前常规应用表柔比星灌注化疗对比效果观察,探索膀胱热灌注化疗对于降低初发浅表性膀胱肿瘤术后复发率的效果,借此为初发浅表性膀胱肿瘤患者术后提供更多有效的治疗选择。研究方法:方法:收集青海大学附属医院、山东大学第二附属医院、莱芜市人民医院泌尿外科2014年2月至2016年1月诊断为初发浅表性膀胱肿瘤患者共107例,分为试验组和对照组。其中试验组患者接受常规TUR-BT,术后给予表柔比星射频热疗机下灌注化疗,对照组患者接受常规TUR-BT,术后给予表柔比星灌注化疗。利用膀胱镜及泌尿系彩超观察两组患者1年内膀胱肿瘤复发情况。统计分析:组间数据使用χ2检验进行分析,以P0.05认为差别有统计学意义。结果:1、试验组患者共31例,1年内复发者6例,未复发者25例,复发率19.35%。2、对照组患者共76例,1年内复发者30例,未复发者46例,复发率39.47%3、两组数据应用χ2检验进行分析,χ2=3.992,P=0.046,差异有统计学意义。结论:(1)浅表性膀胱肿瘤经尿道膀胱肿瘤电切术后,规律给予药物灌注化疗可降低肿瘤复发率;(2)浅表性膀胱肿瘤经尿道膀胱肿瘤电切术后,规律给予表柔比星射频热疗机下热灌注化疗与普通灌注化疗相比,可有效降低肿瘤复发率。
[Abstract]:Objective: to observe the effect of epirubicin radiofrequency hyperthermic perfusion chemotherapy on patients with primary superficial bladder tumor after TUR-BT.To explore the effect of bladder hyperthermic infusion chemotherapy on reducing the recurrence rate of primary superficial bladder neoplasms, so as to provide more effective treatment options for patients with primary superficial bladder neoplasms.Methods: from February 2014 to January 2016, 107 patients with primary superficial bladder tumor were collected from the affiliated Hospital of Qinghai University, the second affiliated Hospital of Shandong University and the Urology Department of Laiwu people's Hospital.They were divided into two groups: experimental group and control group.The patients in the test group received routine TUR-BT, the patients in the control group received routine TUR-BT, and the patients in the control group received epirubicin infusion chemotherapy after operation.Cystoscopy and urography were used to observe the recurrence of bladder tumor in two groups within one year.Statistical analysis: the data between groups were analyzed by 蠂 2 test. The difference was statistically significant (P 0.05).Results in the control group, there were 31 cases, 6 cases recurred within one year, 25 cases did not recur, the recurrence rate was 19.35.2. In the control group, there were 76 cases, 30 cases recurred within one year, and 46 cases did not recur.The recurrence rate was 39.473.The data of the two groups were analyzed by 蠂 2 test. The difference was statistically significant.Conclusion (1) after transurethral resection of superficial bladder neoplasms, regular administration of drug infusion chemotherapy can reduce the recurrence rate of superficial bladder neoplasms after transurethral resection of bladder tumors.Regular administration of epirubicin in radiofrequency hyperthermia machine can effectively reduce the recurrence rate of tumor compared with that of common perfusion chemotherapy.
【学位授予单位】：青海大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R737.14

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