温胃方治疗脾胃虚寒型慢性非萎缩性胃炎的临床研究

发布时间：2018-04-13 11:06

本文选题：温胃方 + 慢性非萎缩性胃炎　；参考：《福建中医药大学》2017年硕士论文

【摘要】：目的:通过观察温胃方治疗前后脾胃虚寒型慢性非萎缩性胃炎患者的临床症状、中医症候等变化情况,探讨温胃方治疗脾胃虚寒型慢性非萎缩性胃炎的认识及临床应用价值,评价其疗效性及安全性。方法:采取随机对照的研究方法,收集符合纳入标准的脾胃虚寒型慢性非萎缩性胃炎患者72例,按随机数字表法分为治疗组与对照组各36例,治疗组予中药"温胃方"治疗,对照组予西药"复方铝酸铋颗粒"治疗,两组均以6周为一疗程,对治疗前后两组的临床综合疗效、中医症候、临床症状、胃镜检查及病理检查改善情况进行疗效评定,以及血常规、肝肾功能、二便及心电图等安全指标,并进行统计分析,评价温胃方的疗效性及安全性。结果:1.两组共纳入72例受试者,治疗组与对照组各36例,治疗组完成33例,对照组完成34例,脱落率6.94%。2.总有效率:治疗组治疗脾胃虚寒型慢性非萎缩性胃炎治愈11例,显效12例,有效5例,无效5例,总有效率84.8%;对照组治愈5例,显效8例,有效12例,无效9例,总有效率73.5%,差异具有统计学意义(P0.05)。3.中医症候改善情况:治疗组在胃脘或脘腹胀满、四肢不温、胃脘疼痛、饮食减少、疲乏无力、大便稀溏等症候的改善优于对照组,其P分别为0.01、0.01、0.05、0.05、0.05、0.05。4.胃镜改善情况:治疗组临床治愈7例,显效6例,有效15例,无效5例,总有效率84.8%;对照组治愈2例,显效2例,有效23例,无效7例,总有效率79.4%,差异具有统计学意义(P0.05)。5.病理改善情况:治疗组临床治愈5例,显效8例,有效14例,无效6例,总有效率81.8%;对照组治愈3例,显效1例,有效20例,无效10例,总有效率70.6%,差异具有统计学意义(P0.05)。6.安全性:治疗后两组患者血常规、肝肾功能、二便及心电图均未见明显异常变化。结论:温胃方在改善脾胃虚寒型慢性非萎缩性胃炎患者的临床症状、中医症候及胃镜和病理检查,具有良好的疗效性和安全性。
[Abstract]:Objective: to observe the changes of clinical symptoms and symptoms of chronic non-atrophic gastritis of deficiency of spleen and stomach before and after treatment with Wenwei recipe, and to explore the recognition and clinical application value of Wenwei prescription in treating chronic non-atrophic gastritis of deficiency cold type of spleen and stomach.To evaluate its efficacy and safety.Methods: a randomized controlled study was conducted to collect 72 patients with chronic non-atrophic gastritis of spleen and stomach deficiency cold type. According to the method of random digital table, the patients were divided into treatment group (n = 36) and control group (n = 36). The treatment group was treated with traditional Chinese medicine "Wenwei prescription".The control group was treated with "compound bismuth aluminate granules", and the two groups were treated with 6 weeks as a course of treatment. The curative effects of the two groups were evaluated before and after treatment, including clinical symptoms, symptoms, gastroscopy and pathological examination.The safety indexes such as blood routine, liver and kidney function, stool and electrocardiogram were analyzed to evaluate the efficacy and safety of Wenwei prescription.The result is 1: 1.There were 72 subjects in the two groups, 36 cases in the treatment group and 36 cases in the control group, 33 cases in the treatment group and 34 cases in the control group, the shedding rate was 6.94.2.Total effective rate: 11 cases of chronic non-atrophic gastritis with deficiency of spleen and stomach were cured in the treatment group, 12 cases were effective, 5 cases were effective, 5 cases were ineffective, and the total effective rate was 84.8 cases in the treatment group, while in the control group, 5 cases were cured, 8 cases were markedly effective, 12 cases were effective, 9 cases were ineffective.The total effective rate was 73.5, and the difference was statistically significant (P 0.05).The improvement of TCM symptoms in the treatment group was better than that in the control group (P = 0.010.01), and the improvement of the treatment group was better than that of the control group (P < 0.01), and the improvement of the symptoms of the treatment group was better than that of the control group (P = 0.011, 0.01), the limbs were not warm, the stomachache, diet reduction, fatigue and loose stools were better than those in the control group (P < 0.05).In the treatment group, 7 cases were cured, 6 cases were effective, 15 cases were effective, 5 cases were ineffective, the total effective rate was 84.8 cases, while in the control group, 2 cases were cured, 2 cases were markedly effective, 23 cases were effective, 7 cases were ineffective, the total effective rate was 79.4%, the difference was statistically significant.Pathological improvement: in the treatment group, 5 cases were clinically cured, 8 cases were effective, 14 cases were effective, 6 cases were ineffective, the total effective rate was 81.8 cases, while in the control group, 3 cases were cured, 1 case was effective, 20 cases were effective, 10 cases were ineffective, the total effective rate was 70.6%, the difference was statistically significant.Safety: there were no obvious abnormal changes in blood routine, liver and kidney function, stool and electrocardiogram in the two groups after treatment.Conclusion: Wenwei prescription has good efficacy and safety in improving the clinical symptoms, symptoms of TCM, gastroscopy and pathological examination in patients with chronic non-atrophic gastritis of deficiency of spleen and stomach.
【学位授予单位】：福建中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259

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