养血定风汤联合自血疗法治疗慢性荨麻疹的临床观察

发布时间：2018-04-14 02:03

本文选题：慢性荨麻疹 + 养血定风汤　；参考：《黑龙江中医药大学》2017年硕士论文

【摘要】：目的:比较养血定风汤联合自血疗法与单纯使用西药在治疗慢性荨麻疹(血虚风燥型)的临床疗效。观察治疗过程中的不良反应和治疗前后对患者生活质量的影响,探讨中西结合治疗在临床上的优势。方法:选取门诊患者中符合纳入标准的80例慢性荨麻疹患者随机分为治疗组和对照组,每组40例。其中治疗组给予养血定风汤合并自血疗法;对照组给予口服依巴斯汀片。记录治疗前两组患者的各项症状积分、生活质量评分及血清学指标。治疗4周后再次记录观察这些指标及治疗过程中的不良反应情况。对比两组患者治疗前后各症状积分有无明显变化、对生活质量的影响及不良反应等情况。比较治疗后两组患者各项对比有无显著差异。观察患者血清总IgE、IL-4、IFN--γ的水平变化。结果:治疗后治疗组12人临床症状消失,18人症状明显改善,5人症状得到缓解;对照组6人症状消失,10人症状明显改善,15人缓解。治疗组痊愈率高于对照组。经过4周疗程后,治疗组和对照组临床各症状积分较治疗前明显降低,患者症状明显减轻。治疗后的两组间积分差异显著,有统计学意义,说明治疗组的疗效优于对照组。根据生活质量调查表发现,治疗后两组生活质量均得到改善。组间比较,治疗后治疗组生活质量积分明显低于对照组,两组比较差异具有显著性(P0.05)。养血定风汤联合自血疗法能够降低荨麻疹对患者生活质量的影响。观察血清学指标检验发现,治疗后两组患者血清总IgE、IL-4水平较治疗前降低,IFN-γ较治疗前升高。治疗后组间比较,养血定风汤联合自血疗法对血清指标的影响更大,差异具有统计学意义(P0.05)。结论:1.养血定风汤联合自血疗法相对于单纯使用西药能更好缓解慢性荨麻疹患者(血虚风燥型)的痛苦,改善临床症状。2.养血定风汤联合自血疗法可降低慢性荨麻疹对患者生活质量的影响。3.养血定风汤联合自血疗法可降低患者血清总IgE、IL-4水平,提高IFN-γ水平,对免疫功能起到一定干预作用。
[Abstract]:Objective: to compare the clinical efficacy of Yangxue Dingfeng decoction combined with self-blood therapy and western medicine alone in the treatment of chronic urticaria (blood deficiency and wind dryness).To observe the adverse reactions in the course of treatment and the influence on the quality of life of the patients before and after treatment, and to explore the clinical advantages of the combination of Chinese and Western treatment.Methods: 80 patients with chronic urticaria were randomly divided into treatment group (n = 40) and control group (n = 40).The treatment group was treated with Yangxue Dingfeng decoction combined with self-blood therapy, while the control group was given oral Ebastine tablets.Symptom score, quality of life score and serological index were recorded before treatment.These indexes and adverse reactions were observed 4 weeks after treatment.The symptom scores before and after treatment, the effects on quality of life and adverse reactions were compared between the two groups.There were significant differences between the two groups after treatment.To observe the level of IFN- 纬 in serum of patients with total IgE and IL-4.Results: after treatment, the clinical symptoms of 12 patients in the treatment group disappeared and the symptoms of 18 patients improved significantly. In the control group, the symptoms disappeared in 6 patients and 10 patients in the control group.The cure rate in treatment group was higher than that in control group.After 4 weeks of treatment, the clinical symptom scores of the treatment group and the control group were significantly lower than those before treatment, and the symptoms of the patients were obviously alleviated.There was significant difference between the two groups after treatment, indicating that the curative effect of the treatment group was better than that of the control group.According to the quality of life questionnaire, both groups were improved after treatment.The scores of quality of life in the treatment group were significantly lower than those in the control group after treatment, and there was a significant difference between the two groups (P 0.05).Yangxue Dingfeng decoction combined with self-blood therapy can reduce the quality of life of patients with urticaria.The serum levels of total IgEN IL-4 in the two groups were lower than those before treatment and IFN- 纬 was higher than that before treatment.After treatment, the effect of Yangxue Dingfeng decoction combined with self-blood therapy on serum indexes was greater, and the difference was statistically significant (P 0.05).Conclusion 1.Yangxue Dingfeng decoction combined with self-blood therapy can relieve the pain of patients with chronic urticaria (blood deficiency wind dryness) and improve clinical symptoms. 2.Yangxue Dingfeng decoction combined with self-blood therapy can reduce the effect of chronic urticaria on the quality of life of patients. 3.Yangxue Dingfeng decoction combined with self-blood therapy can reduce the level of serum IgE IL-4, increase the level of IFN- 纬, and play an intervention role in immune function.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R275.9

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