赤木洗剂凝胶外敷治疗早期膝骨性关节炎的近期疗效观察

发布时间：2018-04-16 05:24

  本文选题：膝骨性关节炎 + 瘀血阻滞型　； 参考：《福建中医药大学》2017年硕士论文

【摘要】：目的:观察赤木洗剂凝胶治疗早期膝骨性关节炎临床疗效、安全性,总结该药的特点及优缺点,为临床应用赤木洗剂凝胶治疗该类型膝骨性关节炎提供理论依据,推广该中药凝胶剂型在临床中的应用。方法:收集山东省文登整骨医院骨关节三科自2016年02月至2016年08月门诊病人符合纳入标准的早期瘀血阻滞型膝骨性关节炎的患者40例,分为实验组、对照组。两组患者均同时口服硫酸氨基葡萄糖胶囊0.628gtid,实验组患者使用赤木洗剂凝胶外敷10gbid,对照组患者使用赤木洗剂烫洗bid,两组均以10d为1个疗程,连续使用3个疗程。实验组:每次使用凝胶治疗前用湿温毛巾清洁患膝皮肤,取赤木洗剂凝胶10g,用刮痧板以髌骨为中心上下10cm范围,均匀涂抹于患膝(包括乆窝部),每日早晚2次。连续使用3个疗程。对照组:患者自取赤木洗剂药包100g,加2L纯净水充分水煮熬制、反复过虑去渣得到赤木洗剂药液,每次使用时首先将加热药液,加热到病人皮肤能承受的温度。然后折叠好的厚度大小适中的纱布用药液浸泡湿备用,患者伸膝,将浸泡湿的纱布敷于以髌骨为中心上下10cm范围,每次30min,纱布温度低时予以更换,每日早晚2次,烫洗完毕后将药液装好置于冰箱保存。每包可重复加温使用10次。连续使用3个疗程。分别于治疗前、治疗后观察记录两组病人的疼痛评分、膝关节Lysholm评分和关节功能分级;观察记录治疗开始后两组病人第1、5、10、20、30天的皮肤刺激征情况。对收集到的数据使用SPSS20.0软件进行统计学分析,计量资料采用t检验或方差分析,计数资料应用卡方或秩和检验。结果:共收集纳入病人40例,其中实验组有1例自行服用干扰药物退出,对照组有2例因皮肤过敏暂停用药退出,实际完成病例37例。实验组平均治疗操作时间比对照组短(P0.05),操作更快捷简便;实验组和对照组的疼痛缓解效果相当(P0.05);对照组皮肤刺激性大于实验组(P0.05);实验组和对照组的膝关节功能分级改善效果相当(P0.05);实验组和对照组的膝关节功能活动改善程度相当(P0.05);症状体征疗效评定总有效率:实验组89.47%,对照组83.33%。结论:赤木洗剂凝胶对于早期瘀血阻滞型膝骨性关节炎有较好的疗效,且其使用安全、方便、快捷,可以在临床上推广使用。
[Abstract]:Objective: to observe the clinical efficacy and safety of Chimu lotion gel in the treatment of early knee osteoarthritis, summarize the characteristics, advantages and disadvantages of this medicine, and provide a theoretical basis for the clinical application of Chimu lotion gel in the treatment of this type of knee osteoarthritis.To popularize the clinical application of the traditional Chinese medicine gel type.Methods: a total of 40 cases of knee osteoarthritis with early blood stasis block type were collected and divided into experimental group and control group from February 2016 to August 2016 in three departments of bone and joint of Wendeng whole Bone Hospital of Shandong Province.The patients in both groups were given glucosamine sulfate capsule 0.628 gtid simultaneously. The patients in the experimental group were treated with Chimu lotion gel and the patients in the control group were treated with Chimu lotion. The patients in the control group were treated with Chimu lotion for a course of 10 days for 3 consecutive courses.Experimental group: the skin of the affected knee was cleaned with wet and warm towel before each treatment, and the skin of the affected knee was cleaned with the gel of Chimu lotion for 10 g. The upper and lower 10cm range of the patella was taken as the center of the palpation plate with the guesta plate. The skin was evenly smeared on the affected knee (including human nests, twice a day).Continuous use of 3 courses of treatment.The control group: the patients took 100 g of Chimu lotion package, added 2L pure water to boil and stay up, and repeatedly removed the slag to get the Chimu lotion solution. Each time, the heating solution was heated to the temperature that the patient skin could bear.Then the folded gauze of moderate thickness was soaked in the medicine solution, and the patient extended his knees. The wet gauze was applied to the upper and lower 10cm area centered on the patella. Each time for 30 minutes, the gauze was changed when the temperature of the gauze was low, twice a day, twice a day.After ironing and washing, put the medicine in the refrigerator and store it.Each package can be reheated 10 times.Continuous use of 3 courses of treatment.The pain score, knee joint Lysholm score and joint function grade were recorded before and after treatment, and the skin irritation symptoms of the two groups were recorded on the 30th day after treatment.The collected data were analyzed by SPSS20.0 software, the data were measured by t test or variance analysis, and the count data were analyzed by chi-square or rank sum test.Results: a total of 40 patients were included in the study group. One patient in the experimental group withdrew from taking interference drugs on his own and two patients in the control group were suspended because of skin allergy. 37 cases were actually completed.The average time of treatment in the experimental group was shorter than that in the control group (P 0.05), and the operation was faster and simpler than that in the control group.The pain relief effect of the experimental group and the control group was similar to that of the control group (P 0.05); the skin irritation of the control group was greater than that of the experimental group (P 0.05); the knee joint function grade of the experimental group and the control group was improved by P0.05; the function of the knee joint was improved in the experimental group and the control group.The total effective rate was 89.47 in the experimental group and 83.33 in the control group.Conclusion: Chimu lotion gel has good curative effect on early blood stasis type knee osteoarthritis, and its use is safe, convenient and quick, and can be popularized in clinic.
【学位授予单位】：福建中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R274.9

【参考文献】

中国期刊全文数据库 前10条

1 孙菊;陈豆;高洁;董晓丽;;中药熏洗配合蜡疗治疗膝关节骨性关节炎42例临床研究[J];现代中医药;2016年06期

2 谭惠予;冯云亮;;温针灸深刺犊鼻、内膝眼治疗膝关节骨性关节炎的临床疗效分析[J];中医临床研究;2016年14期

3 罗奎元;强宇靖;高慧琴;;威灵仙化学成分及药理作用研究进展[J];甘肃中医学院学报;2015年05期

4 邱玲芳;;海桐皮汤熏洗治疗膝关节骨性关节炎的研究进展[J];中外医疗;2015年17期

5 黄百光;黄红;孙红华;;手法配合中药熏洗治疗膝骨性关节炎的临床研究[J];临床医学工程;2015年04期

6 付玉玲;;针灸推拿配合中药治疗早期膝骨性关节炎的效果分析[J];中国卫生标准管理;2015年06期

7 刘强;洪加源;胡维界;;膝骨性关节炎治疗进展[J];医学综述;2015年03期

8 王向红;张建和;王生;王开峰;;关节解痛洗液熏洗治疗膝关节骨性关节炎43例[J];光明中医;2014年11期

9 刘立章;;对中药凝胶剂的研究[J];当代医药论丛;2014年15期

10 梁衍祥;罗立媛;刘海刚;吴继昆;;膝骨性关节炎的治疗研究进展[J];中国医药指南;2014年25期

中国重要会议论文全文数据库 前1条

1 黄朝晖;张素芳;;中药熏洗治疗膝关节骨性关节炎156例[A];首届江西省科协学术年会江西省中医药学术发展论坛论文集[C];2010年

中国博士学位论文全文数据库 前2条

1 莫永豪;温针灸治疗膝骨性关节炎的临床疗效观察[D];广州中医药大学;2015年

2 伍捷进;健骨颗粒冲剂治疗膝骨关节炎的实验研究与临床观察[D];南方医科大学;2012年

中国硕士学位论文全文数据库 前5条

1 毛雪文;温针灸结合剌络放血治疗膝骨性关节炎的临床研究[D];中国中医科学院;2015年

2 苏小龙;赤木洗剂外洗联合PRP关节腔注射治疗前交叉韧带松弛的研究[D];福建中医药大学;2014年

3 王鑫;苏木行血祛瘀活性成分研究[D];济南大学;2013年

4 王丽;温阳益气法治疗阳虚寒凝型膝骨关节炎的临床疗效观察[D];广州中医药大学;2013年

5 刘鑫;痛宁凝胶治疗膝关节骨性关节炎(肾虚筋脉瘀滞证)的临床疗效观察[D];湖南中医药大学;2012年

，

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