TSC1在膀胱尿路上皮癌中的表达情况及其临床意义

发布时间：2018-04-16 17:29

本文选题：膀胱尿路上皮癌 + 抑癌基因　；参考：《吉林大学》2017年硕士论文

【摘要】：目的:通过检测TSC1在正常膀胱组织与膀胱膀胱尿路上皮癌组织中的表达情况,研究TSC1与膀胱膀胱尿路上皮癌的早期诊断、临床病理以及预后的关系。方法:选取膀胱尿路上皮癌组织51例,正常膀胱组织5例。运用免疫组化的方法检测TSC1在膀胱尿路上皮癌组织和正常膀胱组织中的表达情况,并结合患者的临床资料分析讨论TSC1与膀胱尿路上皮癌的关系。结果:51例膀胱尿路上皮癌组织中TSC1的阴性表达率为58.8%,其中非肌层浸润组(Ta-T1)中TSC1的阴性表达率为52.4%,肌层浸润组(T2-)中TSC1的阴性表达率为88.9%,差异有统计学意义(P0.05)。在低分级组中TSC1的阴性表达率为44.4%,高分级组中TSC1的阴性表达率为75.0%,差异有统计学意义(P0.05)。术后随访12-36个月,随访的45例膀胱癌患者中其中复发者共19人,TSC1在复发组中的阴性表达率为73.7%,在未复发组中的阴性表达率为38.5%,差异有统计学意义(P0.05)。通过本次实验我们还发现TSC1的表达情况在肿瘤大小、患者性别以及患者年龄方面无明显差异(P0.05)。结论:TSC1在膀胱尿路上皮癌组织中的阴性表达率明显高于TSC1在正常膀胱组织中的阴性表达率,而且TSC1的表达与膀胱尿路上皮癌的临床分期、病理分级以及是否复发密切相关。可用于膀胱癌的早期诊断、临床分期、病理分级及预后评估。
[Abstract]:Objective: to study the relationship between TSC1 and bladder urothelial carcinoma in early diagnosis, clinicopathology and prognosis by detecting the expression of TSC1 in normal bladder and bladder urothelial carcinoma.Methods: 51 cases of bladder urothelial carcinoma and 5 cases of normal bladder were selected.Immunohistochemical method was used to detect the expression of TSC1 in bladder urothelial carcinoma and normal bladder tissue. The relationship between TSC1 and bladder urothelial carcinoma was discussed in combination with the clinical data of the patients.Results the negative expression rate of TSC1 was 58.8% in 51 cases of bladder urothelial carcinoma, including 52.4% in non-myometrial infiltration group (Ta-T1) and 88.9% in musculocutaneous infiltration group (P 0.05).In the low grade group, the negative expression rate of TSC1 was 44.4, and the negative expression rate of TSC1 in the high grade group was 75.05.The difference was statistically significant (P 0.05).The negative expression rate of TSC1 was 73.7 in the recurrent group and 38.5 in the non-recurrence group. The difference was statistically significant (P 0.05).We also found that there was no significant difference in the expression of TSC1 in tumor size, patient sex and patient age.Conclusion the negative expression rate of TSC1 in bladder urothelial carcinoma is significantly higher than that of TSC1 in normal bladder tissue, and the expression of TSC1 is closely related to the clinical stage, pathological grade and recurrence of bladder urothelial carcinoma.It can be used for early diagnosis, clinical stage, pathological grade and prognosis evaluation of bladder cancer.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R737.14

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