毫火针联合0.1%他克莫司软膏治疗非节段型白癜风的自身对照研究

发布时间：2018-04-25 22:04

  本文选题：白癜风 + 毫火针　； 参考：《广州中医药大学》2017年硕士论文

【摘要】：目的:通过数码成像结合Image-Pro-Plus(IPP)图像处理分析软件的方法,观察毫火针联合他克莫司软膏治疗白癜风的临床疗效。方法:将符合纳入标准的45例白瘢风患者纳入试验,将其靶皮损按照自身对照的方法分为治疗侧、对照侧,治疗侧予毫火针针刺,每周1次,同时外用0.1%他克莫司软膏治疗,每天2次,对照侧单用0.1%他克莫司软膏治疗。两组均在治疗的第0周、第4周、第8周、第12周对靶皮损进行数码图像采集,应用IPP图像处理分析软件计算皮损面积,从而进行相应的统计学处理,同时记录试验中的不良反应。结果:纳入的45例患者,试验中3例患者脱落(均为失访),剩余42例完成规定疗程的治疗。观察皮损共计84块,治疗侧、对照侧各42块。治疗12周后,治疗侧总复色率为39.57%,高于对照侧的10.27%;治疗侧总有效率为80.95%,优于对照侧的59.52%,治疗侧显效率为30.95%,对照侧则为14.29%,两组有效率比较P0.05;治疗4、8、12周后,两组有效率对比,4周后治疗侧有效率为21.38%,对照侧为9.86%(P0.05);8 周后分别为 46.73%、28.26%(P0.05);12 周后分别为 80.95%、59.52%(P0.05)。治疗 4、8、12 周后,治疗侧复色率分别为 9.41%、19.62%、39.52%,对照侧复色率分别为2.04%、7.87%、10.27%,两组比较均P0.05。治疗12周后,皮损复色≥75%的皮损数治疗侧为11块,对照侧为2块。不同因素下两组组间靶皮损复色率比较,颜面部、躯干部两组比较P0.05,其它因素下治疗侧复色率均氋于对照侧。组内不同因素下靶皮损复色率比较,两组在年龄的疗效差异上P0.05,两组在病程≤3年与病程3年的复色率比较P值0.01,在躯干、四肢、手足部的复色率比较P0.01。两组在不同部位的复色率均为手足疗效最差,颜面部疗效最好,但治疗区疗效均氋于对照区。毫火针针刺治疗后均出现红斑、风团、刺痛、灼热感的即刻反应,单用0.1%他克莫司软膏治疗2例出现瘙痒刺痛,余均未出现不适,试验过程中未出现感染、疤痕、同形反应等严重不良反应。结论:毫火针联合0.1%他克莫司软膏治疗稳定期非节段型白癜风的疗效优于单用他克莫司软膏,且起效时间较短。毫火针联合他克莫司软膏治疗白癜风安全、有效,且患者依从性好。
[Abstract]:Objective: to observe the clinical effect of Fuhuo acupuncture combined with tacrolimus ointment in the treatment of vitiligo by digital imaging combined with Image-Pro-Plus-IPP image processing and analysis software. Methods: 45 patients with BCG were included in the trial. The target skin lesions were divided into two groups according to the self-control method: the therapeutic side, the control side and the therapeutic side, once a week, and 0.1% tacrolimus ointment was used externally, and the target skin lesion was treated with 0.1% tacrolimus ointment. Two times a day, the control side was treated with 0.1% tacrolimus ointment. In both groups, the target lesions were collected in the 0, 4, 8 and 12 weeks of treatment. The area of the lesions was calculated by using IPP image processing software, and the corresponding statistical processing was carried out. Adverse reactions in the test were also recorded. Results: of the 45 patients involved, 3 patients dropped out (all of them lost the visit, and the remaining 42 patients completed the prescribed course of treatment. A total of 84 lesions were observed, 42 in the therapeutic side and 42 in the control side. After 12 weeks of treatment, the total recovery rate of the treated side was 39.57, which was higher than that of the control side (10.27%), the total effective rate of the therapeutic side was 80.955, which was better than that of the control side (59.52%), the effective rate of the treatment side was 30.95%, the control side was 14.29, the effective rate of the two groups was higher than that of the control side (P0.05), and the total effective rate of the treatment side was 80.12 weeks after treatment, The effective rate of the two groups was 21.38 after 4 weeks, while that of the control group was 9.86 and that of the control group was 46.73and 28.2628 after 8 weeks respectively. After 12 weeks, it was 80.9552 and 59.52 respectively. After 12 weeks of treatment, the color recovery rate of the treated side was 9.41 and 19.62, respectively, and that of the control group was 2.044 and 7.87 respectively, and that of the control group was 10.27. The two groups were all compared with each other (P0.05). After 12 weeks of treatment, the number of lesions 鈮，

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