新癀片治疗火毒蕴结型早期肛周皮下脓肿的临床疗效观察

发布时间：2018-05-07 00:00

本文选题：早期肛周皮下脓肿 + 火毒蕴结型　；参考：《福建中医药大学》2017年硕士论文

【摘要】：目的:观察新癀片口服加外敷治疗火毒蕴结型早期肛周皮下脓肿的临床疗效。方法:将符合纳入标准的60名受试者按随机数字表随机分为治疗组和对照组。治疗组予新癀片口服加外敷,对照组则予口服黄连解毒汤。两组均以6天为治疗时限,观察患者临床症状、体征及辅助检查等指标的变化情况,观察新癀片口服加外敷治疗火毒蕴结型早期肛周皮下脓肿的临床疗效。结果:完成研究的病例共60例,治疗组(N=30)和对照组(N=30)。治疗前对两组病例的性别、年龄、肛周疼痛、指诊肛周病变肿块触痛、皮温、皮色及超声下肛周肿块大小、CPR等进行均衡性比较,差异均无统计学意义,组间基线一致,具有可比性。研究结果分析如下:(1)两组总体疗效对比情况:治疗组30例患者中,治愈9例,显效12例,有效率80%;对照组30例患者中,治愈5例,显效6例,有效率66.67%。对比两组总体疗效有显著性差异(P0.05)。(2)两组患者临床症状分布情况:两组患者肛周疼痛分布在治疗后及停药1月后对比均有显著性差异(P0.05),新癀片组疗效更显著。(3)两组患者临床体征分布情况:两组患者肛周病变肿块指诊疼痛在治疗后及停药1月后对比均有显著性差异(P0.05),新癀片组疗效更显著;两组患者肿块皮温、皮色在治疗后对比无显著性差异(P0.05),但停药一月后新癀片组疗效更显著(P0.05)。(4)两组辅助检查分布情况:两组患者超声下肛周肿块大小改善的情况在治疗后及停药1月后比较有显著差异(P.0.05),新癀片组疗效更显著;两组在治疗后CRP分布情况比较无显著差异(P.0.05),但停药一月后新癀片组疗效更显著(P.0.05)。(5)复发及不良反应情况:两组停药1月后的复发情况比较有显著性差异(P0.05),实验过程中,两组在用药过程中均未出现明显不良反应。结论:新癀片口服加外敷治疗火毒蕴结型早期肛周皮下脓肿,能明显减轻患者肛周疼痛、皮温及皮色,改善肿块大小及降低CRP等情况,尤其在减轻患者肛周疼痛、改善肿块大小上有明显优势。实验阶段尚未发现不良反应,短期复发率较低,是一种有效且相对较安全的治疗方法。
[Abstract]:Objective: To observe the clinical effect of the oral and external application of new tablets in the treatment of early perianal abscess of anorectal abscess. Methods: 60 subjects were randomly divided into the treatment group and the control group according to the random number table. The treatment group was given the new tablets orally plus external application, and the control group was given oral Huanglian Jiedu soup. The two groups were treated with 6 days as the treatment. To observe the changes of the clinical symptoms, signs and auxiliary examination of the patients, observe the clinical effect of the oral and external application of the new tablet in the treatment of the early perianal abscess of the poison implication type. Results: 60 cases were completed, the treatment group (N=30) and the control group (N=30). The sex, age, perianal pain, and finger diagnosis of the two groups of cases before treatment. The pain of perianal lesions, skin temperature, skin color and ultrasonic perianal mass size, CPR and so on were compared, the differences were not statistically significant, the baseline of the group was the same. The results were as follows: (1) the total effect of the two groups was compared: in the 30 patients of the treatment group, 9 cases were cured, 12 cases were markedly effective and 30 patients in the control group. In the 5 cases, 5 cases were cured, 6 cases were markedly effective, and the total effective difference between the two groups was significantly different (P0.05). (2) the distribution of clinical symptoms in the two groups: the two groups were significantly different in the distribution of perianal pain after the treatment and after the withdrawal of the drug after January (P0.05). (3) the distribution of clinical signs in the two groups: two groups. There were significant differences in the pain between the patients after the perianal lesion and after the drug withdrawal in January (P0.05), and the effect of the new group was more significant. There was no significant difference between the two groups of mass skin temperature and skin color (P0.05) after the treatment (P0.05). (4) the distribution of two groups of auxiliary examinations: two groups of patients. The improvement of the size of the perianal mass was significantly different after the treatment and after the withdrawal in January (P.0.05). The effect of the new group was more significant (P.0.05). There was no significant difference in the CRP distribution in the two groups after the treatment (P.0.05). (5) the recurrence and adverse reaction: the two group stopped after January. There was a significant difference in recurrence (P0.05). During the experiment, the two groups had no obvious adverse reactions during the course of the drug use. Conclusion: the oral and external application of new tablets in the treatment of early perianal abscess in the early perianal abscess can obviously reduce the pain of the anus, skin temperature and skin color, improve the size of the mass and reduce the condition of CRP. It is an effective and relatively safe treatment to light patients with perianal pain and to improve the size of the mass.

【学位授予单位】：福建中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R266

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