原发性高血压与焦虑情绪的相关性研究

发布时间：2018-05-15 08:30

本文选题：原发性高血压 + 焦虑　；参考：《安徽医科大学》2017年硕士论文

【摘要】：目的:探讨原发性高血压与焦虑情绪的关系以及原发性高血压伴发焦虑情绪的危险因素。方法:采用随机抽样的方法,收集2016年3月至2016年8月于我院心血管内科门诊就诊的原发性高血压患者84例,男53例,女31例。收集2016年3月至2016年8月于我院肿瘤科、呼吸科住院的年龄、性别、文化程度等均与研究组相匹配的其他慢性病患者,包括肿瘤患者和慢性阻塞性肺疾病患者为疾病对照组,共47例,男26例,女21例。选取年龄、性别、文化程度等均与研究组相匹配的健康志愿者为正常健康对照组,共57例,男36例,女21例。对84例原发性高血压患者、47例其他慢性病患者以及57例健康对照分别评定汉密尔顿焦虑量表(Hamilton Anxiety Scale,HAMA)、广泛性焦虑量表(Generalized Anxiety Disorder7-item,GAD-7)、汉密尔顿抑郁量表(Hamilton Depression Scale,HAMD)、艾森克人格问卷(Eysenck Personality Questionnaire,EPQ)。将高血压组按高血压分级标准分为1级、2级、3级,分析比较不同等级高血压三组间的一般情况和各量表间的差异。并进一步比较,原发性高血压伴与不伴焦虑情绪的一般情况和各量表之间的差异。使用多因素Logistic回归分析寻找原发性高血压伴发焦虑情绪的危险因素。结果:原发性高血压组伴发焦虑情绪患者共29例,男14例,女15例,其焦虑发生率为34.52%;正常对照组焦虑患者共9人,男3例,女6例,其焦虑发生率为15.79%;其他慢性疾病组焦虑患者共12人,男11例,女1例,其焦虑发生率为25.53%。原发性高血压组焦虑发生率显著高于正常对照组和其他慢性疾病组(P均0.05);原发性高血压组艾森克人格问卷-内外向(EPQ-E)因子评分显著低于慢性病组(P0.05),但与健康对照组差异无显著性(P0.05);随着原发性高血压等级的增加,患者的焦虑和艾森克人格问卷-神经质(EPQ-N)因子评分逐渐增加,且1级和3级高血压之间焦虑和神经质评分具有显著差异(P0.05)。单因素分析显示女性、病程长、血压控制不佳、合并抑郁、高血压分级高、高血压危险分层高是原发性高血压伴发焦虑的相对危险因素。多因素Logistic回归分析示高神经质评分是原发性高血压伴发焦虑的独立危险因素。结论:焦虑发生与原发性高血压密切相关,其中神经质因子对焦虑发生起着重要作用。
[Abstract]:Objective: to investigate the relationship between essential hypertension and anxiety and the risk factors of anxiety in patients with essential hypertension. Methods: from March 2016 to August 2016, 84 patients with essential hypertension, 53 males and 31 females, were randomly selected. From March 2016 to August 2016, the patients with chronic diseases, including tumor patients and patients with chronic obstructive pulmonary disease (COPD), who were hospitalized in the Department of Oncology in our hospital from March 2016 to August 2016, were matched with the study group in terms of age, sex, education level, etc. There were 47 cases, 26 males and 21 females. A total of 57 healthy volunteers, 36 males and 21 females, were selected as normal control group. In 84 patients with essential hypertension, 47 patients with other chronic diseases and 57 healthy controls were assessed with Hamilton Anxiety scale, generalized Anxiety anxiety scale with generalized Anxiety disorder GAD-7, Hamilton Depression scale with Hamd, Eysenck Personality questionnaire with EPQQ. The hypertension group was divided into 1 grade, 2 grade and 3 grade according to the grade of hypertension, and the general situation and the difference of each scale among the three groups of different grades of hypertension were analyzed and compared. Furthermore, the general situation of essential hypertension with and without anxiety and the differences among the scales were compared. Multivariate Logistic regression analysis was used to find out the risk factors of anxiety in patients with essential hypertension. Results: there were 29 patients (14 males and 15 females) with anxiety in the group of essential hypertension, the incidence rate of anxiety was 34.522.In the control group, there were 9 patients with anxiety, 3 males and 6 females. The incidence of anxiety was 15.79 and the incidence of anxiety was 25.53 in 12 patients with other chronic diseases including 11 males and 1 female. The incidence of anxiety in the essential hypertension group was significantly higher than that in the normal control group and other chronic disease groups (P 0.05), and the Eysenck personality questionnaire (EPQ-EQ) score in the essential hypertension group was significantly lower than that in the chronic disease group (P 0.05), but it was significantly lower than that in the healthy control group. There was no significant difference between the two groups (P 0.05), and with the increase of the grade of essential hypertension, The scores of anxiety and Eysenck Personality questionnaire (Eysenck Personality Questions-EPQ-N) increased gradually, and there was significant difference in anxiety and neuroticism between grade 1 and grade 3 hypertension (P 0.05). Univariate analysis showed that long course of disease, poor blood pressure control, depression, high grade of hypertension and high risk stratification of hypertension were the relative risk factors of anxiety in patients with essential hypertension. Multivariate Logistic regression analysis showed that high neuroticism score was an independent risk factor for essential hypertension with anxiety. Conclusion: anxiety is closely related to essential hypertension, and neurotic factors play an important role in the occurrence of anxiety.
【学位授予单位】：安徽医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R544.11;R749.72

【参考文献】