D-二聚体水平与结肠癌临床及预后的相关性研究

发布时间：2018-05-18 11:16

  本文选题：结肠癌 + 临床病理特征　； 参考：《新疆医科大学》2017年硕士论文

【摘要】：目的:探讨血浆D-二聚体水平与结肠癌临床病理特征之间的关系,分析血浆D-二聚体水平与结肠癌患者生存期之间的关系。方法:选择新疆军区总医院2006年1月-2011年12月期间确诊的结肠癌患者124例,完整录入患者一般信息,并对其进行随访。用统计学方法分别分析血浆D-二聚体水平与结肠癌患者临床病理特征和生存期之间的关系。结果:观察组D-二聚体水平高于体检组(P0.05),有淋巴结转移组D-二聚体水平高于无淋巴结转移组(P0.05),中低分化组D-二聚体水平高于高分化组(P0.05),Ⅲ、Ⅳ期患者的D-二聚体水平高于Ⅰ、Ⅱ期患者(P0.05),死亡组D-二聚体水平高于生存组(P0.05),血浆D-二聚体水平较高者5年生存率低于血浆D-二聚体水平较低者。单因素分析中年龄、TNM分期、淋巴结转移、分化程度和D-二聚体水平是影响结肠癌患者预后的重要影响因素,多因素分析中提示患者临床分期和D-二聚体水平是影响患者预后的独立因素。结论:D-二聚体水平与结肠癌临床病理特征以及预后呈正相关,对其进行检测对结肠癌临床的诊断和预后评估有一定临床价值。
[Abstract]:Objective: to investigate the relationship between plasma D-dimer level and clinicopathological features of colon cancer, and to analyze the relationship between plasma D-dimer level and survival time of colon cancer patients. Methods: 124 patients with colon cancer diagnosed in Xinjiang military region General Hospital from January 2006 to December 2011 were selected and their general information was recorded and followed up. The relationship between plasma D-dimer level and clinicopathological features and survival time of colon cancer patients was analyzed by statistical method. Results: the level of D-dimer in the observation group was higher than that in the control group, the level of D-dimer in the group with lymph node metastasis was higher than that in the group without lymph node metastasis, the level of D-dimer in the group with middle and low differentiation was higher than that in the group with high differentiation, the level of D-dimer in the patients with stage 鈪，

本文编号：1905623