穴位敷贴结合助孕散治疗多囊卵巢综合征不孕的临床研究

发布时间：2018-05-22 12:12

本文选题：助孕散 + 穴位敷贴　；参考：《广州中医药大学》2017年硕士论文

【摘要】：目的通过观察穴位敷贴结合助孕散治疗多囊卵巢综合征不孕的临床疗效,从而为临床穴位敷贴结合助孕散治疗多囊卵巢综合征不孕提供真实可靠的依据,客观评价穴位敷贴结合助孕散的临床应用价值。方法采用完全随机法将纳入研究的68名合格受试者随机分为治疗组:穴位敷贴+助孕散内服组(A组);对照组:单纯助孕散内服组(B组)。A组每日一剂,月经期停止服药,穴位敷贴方法:月经干净后第三天开始敷药,每天一次,至月经来潮停止,三个月为一疗程,共四个疗程,若怀孕则停止治疗。B组中药服用方法同A组,三个月为一疗程,共观察四个疗程,若怀孕则停止治疗。两组的年龄、病程、备孕时间、治疗前生殖内分泌指标研究分析,差异无统计学意义(P0.05),具有可比性。每月检测排卵一次,分别记录治疗前和治疗后患者B超监测卵泡与排卵情况、妊娠情况、内分泌激素测定数据整理并进行统计分析。结果1.排卵率情况A组患者共治疗200个周期,恢复排卵周期有111个,排卵率55.43%;B组共治疗284个周期,排卵周期有93个,排卵率32.73%。A组与B组治疗后组间比较,A组治疗后较B组治疗后有显著差异(P=0.0000.05),A组排卵率高于B组。2.妊娠率情况A组治疗后妊娠21例,未妊娠10例,妊娠率67.74%;B组治疗后妊娠17例,未妊娠14例,妊娠率54.84%。A组与B组治疗后组间比较,A组和B组治疗后妊娠率无统计学意义P=0.297(P0.05),但对治疗周期进行统计分析发现,A组的治疗周期明显小于B组,差异有统计学意义P=0.004(P0.05)3.睾酮情况分别对两组治疗前后T进行组内统计分析,A组与B组T指标治疗前后比较,差异具有统计学意义PA=0.00、PB=0.023(P0.05)。分别对两组治疗后T指标进行组间统计分析,差异具有统计学意义P=0.007(P0.05),对两组治疗前后T指标差值进行统计分析,A组与B组比较差异具有统计学意义P=0.004(P0.05)。研究结果表明,A、B两组都能降低患者T指标水平,但是A组对于T指标血液中的水平改善情况比B组好。4.LH/FSH 情况分别对两组治疗前后LH/FSH进行组内统计分析,A、B两组治疗前后比较,差异具有统计学意义PA=0.00、PB=0.013(P0.05),分别对两组治疗后LH/FSH比值进行组间统计分析,差异具有统计学意义P=0.000(P0.05),对两组治疗前后LH/FSH比值差值进行统计分析,A组与B组比较差异具有统计学意义P=0.000(P0.05)。数据表明A、B两组均能明显降低患者LH/FSH比值水平,对于LH/FSH比值水平的改善,A组优于B组。结论(1)两组均能改善患者排卵情况,且A组优于B组。同时,两组能提高妊娠率,A、B两组在治疗后妊娠情况相当,但是A组能明显缩短治疗周期。(2)两组均能明显降低患者血液中T指标水平情况,对于T指标水平的改善,A组疗效优于B组。(3)两组均能明显降低患者LH/FSH水平,对于LH/FSH水平的改善,A组优于B组。
[Abstract]:Objective to observe the clinical efficacy of acupoint application combined with Zhuyong powder in the treatment of infertility with polycystic ovary syndrome (PCOS), so as to provide a true and reliable basis for the treatment of polycystic ovary syndrome infertility. Objective to evaluate the clinical application value of acupoint application combined with Zhuyong powder. Methods A total of 68 eligible subjects were randomly divided into treatment group (group A) and control group (group A), group B (group B), group A (group A), group A (group A) and group A (group A). Acupoint application: the third day after menstruation is clean, once a day, until menstruation stops, three months as a course of treatment, a total of four courses of treatment, if pregnant, stop treatment group B Chinese medicine take the same method as group A, three months as a course of treatment, Observe a total of four courses of treatment, if pregnant, stop treatment. The age, course of disease, pregnancy preparation time and reproductive endocrine index before treatment in the two groups were studied and analyzed. There was no significant difference between the two groups (P 0.05), and the difference was comparable. Ovulation was detected once a month. B ultrasound was recorded before and after treatment to monitor follicle and ovulation, pregnancy, endocrine hormone test data and statistical analysis. Result 1. The ovulation rate in group A was 200 cycles, the recovery cycle was 111 cycles, the ovulation rate was 55.43B group (284 cycles), and the ovulation cycle was 93 cycles (93 cycles). The ovulation rate of group A was significantly higher than that of group B after treatment. The ovulation rate of group A was higher than that of group B (P < 0.05). The pregnancy rate in group A was 21 cases after treatment, 10 cases without pregnancy, 17 cases with pregnancy after treatment in group B, 14 cases without pregnancy. The pregnancy rate of group A was 54.84.There was no significant difference between group A and group B after treatment, but the treatment cycle of group A was significantly smaller than that of group B (P 0.004 P 0.053). Statistical analysis of T in two groups before and after treatment. The difference between group A and group B was statistically significant before and after treatment. The difference was statistically significant between group A and group B, and the difference was statistically significant between group A and group B before and after treatment. Statistical analysis was made between the two groups of T indexes after treatment, the difference was statistically significant (P0. 007 / P0. 05). The difference between group A and group B was statistically significant (P0. 004) and P0. 05% (P < 0. 05). The results showed that both group A and B could decrease the level of T index, but the improvement of blood level in group A was better than that in group B. the LH/FSH of group A before and after treatment was compared with that of group B before and after treatment. The difference was statistically significant (P < 0.05). The ratio of LH/FSH in two groups after treatment was statistically analyzed. The difference was statistically significant (P < 0.05). The difference of LH/FSH ratio between group A and group B was statistically significant (P = 0.000). The data showed that both group A and B could significantly reduce the ratio of LH/FSH, and the improvement of the ratio of LH/FSH in group A was better than that in group B. Conclusion both groups can improve ovulation, and group A is superior to group B. At the same time, the two groups could increase the pregnancy rate. The pregnancy rate of group A and group B were similar after treatment, but group A could shorten the treatment cycle significantly.) both groups could significantly reduce the level of T index in blood of patients. The improvement of T index in group A was better than that in group B (P < 0.05). The level of LH/FSH in group A was significantly lower than that in group B, and the level of LH/FSH in group A was better than that in group B.
【学位授予单位】：广州中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R246.3

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