妊娠禁忌中药的文献研究

发布时间：2018-05-31 19:14

本文选题：妊娠禁忌中药 + 四性　；参考：《南京中医药大学》2017年硕士论文

【摘要】：背景:随着生活水平的提高,药品安全越来越受到人们的重视,尤其以妊娠期的药品安全为最。孕妇特有的生理特点使得她对药物的敏感度提升,成为用药安全最需要注意的群体。其次,随着药理实验的不断深入,许多常用中药被检测出含有妊娠毒性和遗传毒性,而一些传统的妊娠禁忌中药却被用于治疗妊娠期疾病。妊娠禁忌中药应该依照一个什么样的标准,才能做到安全用药,这就需要对妊娠禁忌中药进行新一轮的整理和分析。目的:整理本草文献和现代药理研究中出现的妊娠禁忌中药,建立数据库,并进行四性,五味,归经,功效,临床和药理实验分门别类的归纳和数据挖掘,以期能得出妊娠禁忌中药的相关特点,为妊娠禁忌中药的安全性评级提供参考。结果:共检索出妊娠禁忌中药1136味。进行数据挖掘,发现妊娠禁忌中药中药"性""的分布以温、寒、平、凉递减分布,热性所占比例较小;"味"的分布以苦、辛最多,约占总比例的70%,其次为甘酸咸;归经分布以肝经为最多,约占31%,其余肺、脾、胃、肾为分布较多的归经,均在10%以上,大肠、心经为9%,其余5经分布较少。相关对应分析发现,辛温、苦寒、苦温平为出现频率较高的性味组合。寒肝,温肝为出现频率最高的性归经组合。苦肝、辛肝为出现频率最高的味归经组合毒性对应分析结果显示,有毒药物占妊娠禁忌中药总和的29%。最常出现的几种功效为解毒、活血、止痛、祛风、清热、消肿、除湿、散瘀、止血、利湿、杀虫等,并进行了功效与性、味、归经之间的关联分析。临床实验文献总结中发现一些传统妊娠禁忌中药对于妊娠高血压、妊娠糖尿病、妊娠剧吐、宫外孕等疾病具有良好的疗效,药理实验文献总结中以有妊娠毒性、无妊娠毒性、兴奋子宫、遗传毒性、抗早孕、肿瘤进行了分类归纳。结论:本文对妊娠禁忌中药进行了整理和归纳,分析了药物性、味、归经、功效的特点以及相互关系,分类归纳了临床和药理实验的相关文献。为进一步研究妊娠禁忌中药,确立妊娠禁忌中药的安全性评级,以及妊娠禁忌中药的跨领域研究提供了文献基础,并为临床安全用药提供参考。
[Abstract]:Background: with the improvement of living standard, people pay more and more attention to drug safety, especially during pregnancy. The physiological characteristics of pregnant women make her more sensitive to drugs and become the most important group for drug safety. Secondly, with the deepening of pharmacological experiments, many commonly used Chinese medicines have been detected to contain gestational toxicity and genetic toxicity, while some traditional contraindications are used to treat gestational diseases. What kind of standard should be followed in pregnancy taboo Chinese medicine, which requires a new round of collation and analysis of pregnancy taboo Chinese medicine. Objective: to sort out the pregnancy contraindication Chinese medicine appeared in the literature and modern pharmacological research of this herb, to establish the database, and to make the induction and data mining of the four properties, five flavors, meridians, efficacy, clinical and pharmacological experiments. In order to obtain the relevant characteristics of pregnancy contraindication Chinese medicine, and provide a reference for the safety rating of pregnancy taboo Chinese medicine. Results: a total of 1136 kinds of pregnancy contraindications were found. Through data mining, it was found that the distribution of "sex" in pregnancy taboo Chinese medicine was temperature, cold, flat, cool decreasing distribution, the proportion of heat was small, the distribution of "taste" was bitter, the most, about 70% of the total proportion, followed by glycolic acid salt; The distribution of the meridian of the liver was the most, accounting for 31%, the other lungs, spleen, stomach and kidney were more than 10%, the large intestine and heart meridian were 9 parts, and the other 5 meridians were less. Correlation analysis showed that Xin Wen, bitter cold and bitter warm level were high frequency combinations of sexual taste. Cold liver, warm liver is the highest frequency of sexual meridian combination. Bitter liver, xinggan is the highest frequency of taste combination toxicity analysis results show that the toxic drugs accounted for 29% of the total gestational taboo Chinese medicine. The most common effects are detoxification, activating blood circulation, relieving pain, dispelling wind, clearing heat, eliminating swelling, dehumidification, dispersing stasis, hemostasis, dampness, killing insects, etc. In the summary of clinical experimental literature, it was found that some traditional Chinese medicine had good curative effect on pregnancy hypertension, gestational diabetes mellitus, hyperemesis of pregnancy, ectopic pregnancy and other diseases. Excitatory uterus, genetic toxicity, anti-early pregnancy, tumor were classified and summarized. Conclusion: the contraindications of traditional Chinese medicine for pregnancy are summarized and summarized. The characteristics of medicine, taste, meridian, efficacy and the relationship between them are analyzed, and the related literatures of clinical and pharmacological experiments are classified and summarized. It provides a literature basis for further study on pregnancy contraindication Chinese medicine, establishing the safety rating of pregnancy taboo Chinese medicine, and cross-domain research on pregnancy taboo Chinese medicine, and provides a reference for clinical safety drug use.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R28

【参考文献】