中药外敷治疗良性单纯性甲状腺结节的临床疗效观察

发布时间：2018-06-10 16:48

本文选题：中药外敷 + 良性单纯性甲状腺结节　；参考：《黑龙江中医药大学》2017年硕士论文

【摘要】：目的:观察中药外敷治疗良性单纯性甲状腺结节(肝郁痰凝血瘀型)的临床疗效,研究该膏药方对良性单纯性甲状腺结节的影响,以及该膏药方的有效性和安全性,并对本次研究内容及数据结果进行总结和分析后进一步规范中药外敷的技术操作方法,以期找到一种有效、安全、规范、便于临床操作的中医外治本病的方法。方法:此次研究采用的是随机对照方法,将符合良性单纯性甲状腺结节(肝郁痰凝血瘀型)诊断标准的60例患者随机分为两组,治疗组予以中药外敷联合口服夏枯草颗粒,对照组为口服夏枯草颗粒,观察12周。12周后进行临床疗效评价,评估治疗前后两组患者临床症状和体征的变化,以及相关指标的变化,包括甲状腺最大结节直径、甲状腺功能、肝肾功能、血常规、安全性指标、中医症候积分以及疗效评分,并做记录。对照治疗前后是否改善、好转还是没有变化,对实验结果进行统计学分析。本次观察全部数据采用SPSS 17.0软件进行统计学分析。结果:符合纳入标准的患者,治疗前两组患者的性别、年龄、病程、甲状腺结节的最大结节直径等无显著性差异(P0.05),说明两组数据具有可比性。在总的有效率、中医症状疗效、中医症状积分、甲状腺结节缩小程度等方面,存在着差异(P0.05)。结合实验研究结束后的随访表明,在中药外敷联合口服夏枯草颗粒治疗良性单纯性甲状腺结节方面的复发率优于单纯口服夏枯草颗粒。结论:从初步临床研究分析,中药外敷联合口服夏枯草颗粒可以改善良性单纯性甲状腺结节患者的临床症状、缩小结节大小、降低复发率,未引起患者的甲状腺功能及甲状腺抗体的变化,未见肝肾功能的损害,此方法安全、经济、有效、可靠,其作用机制值得进一步研究,为广大患者降低痛苦。
[Abstract]:Objective: to observe the clinical effect of external application of traditional Chinese medicine on benign simple thyroid nodules (liver stagnation, phlegm and blood stasis), and to study the effect of the plaster on benign simple thyroid nodules, as well as the efficacy and safety of the plaster. The contents and data of this study were summarized and analyzed to further standardize the technical operation method of external application of traditional Chinese medicine in order to find an effective, safe, standardized and convenient method for external treatment of this disease. Methods: in this study, 60 patients with benign thyroid nodules (liver depression, phlegm and blood stasis) were randomly divided into two groups. The control group was treated with Prunella vulgaris granules. The clinical efficacy was evaluated after 12 weeks and 12 weeks. The changes of clinical symptoms and signs, as well as the changes of related indexes, including the diameter of the largest thyroid nodule and the thyroid function, were evaluated before and after treatment. Liver and kidney function, blood routine, safety index, TCM symptom score and curative effect score, and record. Control before and after treatment, improvement or no change, the experimental results were statistically analyzed. All the data were analyzed by SPSS 17.0 software. Results: there was no significant difference in sex, age, course of disease and the diameter of the largest nodule of thyroid nodule between the two groups before treatment (P 0.05), which indicated that the data of the two groups were comparable. There are differences in the total effective rate, the curative effect of TCM symptoms, the integral of TCM symptoms, the degree of reduction of thyroid nodules, and so on. Combined with the follow-up after the experimental study, the recurrence rate of traditional Chinese medicine combined with oral Prunella granulosa in the treatment of benign simple thyroid nodules was better than that of oral Prunella granulosa. Conclusion: from the preliminary clinical study, the clinical symptoms of benign simple thyroid nodules can be improved, the size of nodules and the recurrence rate can be reduced by external application of traditional Chinese medicine combined with oral administration of Prunella solani granules. This method is safe, economical, effective and reliable. Its mechanism is worthy of further study and can reduce the pain for the majority of patients.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259

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