我国极低出生体质量早产儿并发支气管肺发育不良危险因素的Meta分析

发布时间：2018-06-11 22:06

  本文选题：支气管肺发育不良 + 危险因素　； 参考：《安徽医学》2016年10期

【摘要】：目的运用循证医学探讨我国极低出生体质量早产儿并发支气管肺发育不良的危险因素。方法系统检索Pub Med、Embase、万方数据库、中国期刊全文数据、中国知网(CNKI)、中文科技期刊全文数据、Cochrane临床对照试验资料库、中国生物医学文献数据库(CBM),检索时间均从建库至2016年5月。按纳入排除标准进行随机对照试验的筛选、资料提取和文献质量评价,应用Stata 11.0软件进行meta分析。结果共纳入15篇对照试验研究,mate分析结果显示,胎膜早破(OR=1.90,95%CI:1.16~3.11),肺透明膜病(OR=6.46,95%CI:4.47~9.35),吸氧时间(RR=3.01,95%CI:1.34~4.69),肺部感染(OR=15.76,95%CI:7.51~33.07),生后窒息(OR=2.23,95%CI:1.09~4.57),产前感染(OR=3.41,95%CI:2.40~4.84),动脉导管未闭(OR=3.39,95%CI:2.04~5.64),胎龄(RR=-2.34,95%CI:-3.42~-1.27),出生体质量(RR=-2.08,95%CI:-2.91~-1.21)是极低出生体质量早产儿并发支气管肺发育不良的危险因素;产后使用肺表面活性物质(OR=4.09,95%CI:1.65~10.12)是其保护因素。结论应积极对极低出生体质量早产儿并发支气管肺发育不良危险因素采取预防措施,从而降低支气管肺发育不良的发生率,提高生存率及改善远期生活质量。
[Abstract]:Objective to explore the risk factors of bronchopulmonary dysplasia in very low birth weight preterm infants in China. Methods Pub Medbase, Wanfang database, full text data of Chinese journals, CNKII of China, Cochrane clinical controlled trial database of Chinese scientific and technological journals, CBMN of Chinese biomedical literature database were searched systematically. The retrieval time was from the establishment of the database to May 2016. According to exclusion criteria, random controlled trial screening, data extraction and literature quality evaluation were carried out, and meta analysis was carried out with Stata 11.0 software. Results A total of 15 controlled trials were included, and the results of mate analysis showed that, 鑳庤啘鏃╃牬(OR=1.90,95%CI:1.16~3.11),鑲洪，

本文编号：2006863