traditional Chinese medicine prevention post

  本文关键词：中医药预防ERCP术后胰腺炎的Meta分析，由笔耕文化传播整理发布。

中医药预防ERCP术后胰腺炎的Meta分析

Role of Traditional Chinese Medicine In Prevention of Post-ERCP Pancreatitis： A Meta-analysis

[1] [2] [3]

DENG Fang-fan, CAO Miao, ZHANG Wen-xing （1. Hu＇nan University of Chinese Medicine, Changsha Hu＇nan 410208, China; 2. The First Affiliated Hospital of Hu＇nan University of Ch

[1]湖南中医药大学,湖南长沙410208; [2]湖南中医药大学第一附属医院,湖南长沙410007

文章摘要：目的：评价中医药预防ERCP术后胰腺炎（post-ERCP pancreatitis,PEP）的有效性和安全性。方法：计算机检索Pub Med、CNKI、VIP和Wan Fang Data数据库,时间均为建库至2014年9月,收集中医药防治ERCP术后急性胰腺炎的随机对照试验。由两名研究者独立选择文献、提取资料,应用Cochrane系统评价手册（5.3.3版）标准结合Jadad评分法进行质量评价,使用Rev Man5.3.3软件进行统计分析。结果：经筛选最终纳入10篇文献进行Meta分析,共974例患者。Meta分析结果显示：（1）高淀粉酶血症发生率：两组差异均有统计学意义[OR：0.40 95%CI：0[0.28,0.56]Z=5.255,P〈0.001],说明治疗组术后高淀粉酶血症发生率小于对照组;（2）急性胰腺炎发生率：两组差异有统计学意义[OR：0.3295%CI：[0.18,0.56]Z=33.93,P〈0.001],治疗组术后急性胰腺炎发生率小于对照组;（3）其他指标：术后2~4 h血淀粉酶差异无统计学意义;术后12、24、48、72 h血淀粉酶水平、血淀粉酶恢复时间及腹痛（或临床症状）缓解时间、IL-6水平、CRP水平两组间差异有计学意义。结论：本系统评价结果显示,有较强证据表明中医药较单纯西医预防ERCP术后胰腺炎有优势,不良反应少。但是相关试验存在一定的方法学问题,质量较低,尚需更多研究进一步验证。

Abstr：Objective： To evaluate the effectiveness and safety of traditional Chinese medicine in the prevention of post-endoscopic retrograde cholangiopancreatography（ERCP） pancreatitis（PEP）. Methods： The following databases such as Pub Med, CNKI, Wanfangang VIP were searched to collect the randomized controlled trials（RCTs） on traditional Chinese medicine in the prevention of PEP from intiation establishment of database to September, 2014. The selection of studies, assessment of methodological quality and data extraction were performed independently by two reviewers according to the Cochrane systematic review methods and Jadad score system, and Meta-analyses were performed by using Rev Man 5.3.3 software. Results： A total of 10 RCTs involving 974 cases were included after the selection. The results of Meta-analyses indicated that compared with the control group, the experimental group for post ERCP incidence rate of hyperamylasemia was superior（OR：0.40 95%CI：[0.28,0.56] Z=5.255, P〈0.001）, incidence rate of acute pancreatitis（OR：0.32 95%CI：[0.18,0.56] Z=33.93,P 0.001）, with significant differences. There was no statistical difference on blood amylase of 2-4hours after the operation. blood amylase of 12, 24, 48 and 72 hours after the operation, the levels of IL-6 and CRP,the recovery time of blood amylase and the relief time of abdominal pain（or clinical symptom） were significantly different. Conclusions： The evaluation results showed that there was strong evidence indicated that traditional Chinese medicine have advantage over single therapy of western medicine, but there are some methodological problems in the studies. Due to the poor quality and method of the included studies, more well designed RCTs should be performed.

文章关键词：

Keyword：:traditional Chinese medicine prevention post-ERCP pancreatitis meta-analysis

  本文关键词：中医药预防ERCP术后胰腺炎的Meta分析，，由笔耕文化传播整理发布。