右归丸加减方治疗肝肾亏虚型骨质疏松症的临床观察

发布时间：2018-06-24 04:53

本文选题：右归丸加减方 + 肝肾亏虚骨质疏松症　；参考：《黑龙江中医药大学》2017年硕士论文

【摘要】：目的:观察右归丸加减方治疗骨质疏松症的临床疗效,并与珍牡肾骨胶囊治疗骨质疏松症进行对比,从而引出右归丸加减方治疗骨质疏松的作用机理,探讨中医中药治疗骨质疏松症的缺点及不足,从而丰富骨质疏松症临床用药。方法:本研究在中医辨证论治、整体观念的指导下对肝肾亏虚型骨质疏松症患者服用右归丸加减方、珍牡肾骨胶囊后的临床疗效进行了细致的研究。将符合纳入标准的患者(60人)随机分为治疗组(30人),对照组(30人)。治疗组给予右归丸加减方,患者每次服用1丸,每日服用2次。早晚温水送服。对照组给予珍牡肾骨胶囊1粒日三次口服。连续服用两个月,观察患者病情。在观察试验开始前,分别详细记录每个患者临床症候、骨密度情况波动变化,统计用药后患者治愈率及用药半年后患者中医症候反弹情况。结果:记录数据提示:在观察试验之前临床症候、骨密度情况波动变化经统计学分析后无明显差异,说明两组可比性大。治疗组与对照组分别服用右归丸加减方与珍牡肾骨胶囊3个月后,再次详细记录每个患者临床症候、骨密度情况波动变化。记录数据提示:在观察试验之后临床症候变化幅度较大,统计学意义明显,骨密度情况变化幅度无明显差异。结论:通过数据分析可推测,右归丸加减方与珍牡肾骨胶囊在肝肾亏虚骨折疏松症患者治疗上都具有一定的疗效,且治疗组优于对照组。但两种药物都具有一定的失访率,且失访患者都为严重骨质疏松患者。可推测对于严重的骨质疏松患者的治疗,单独使用右归丸加减方或珍牡肾骨胶囊的疗效不佳,对于严重骨质疏松症的治疗结果不佳,应联合用药,辅助其他治疗方案。讨论部分对右归丸治疗骨质疏松症的药物机理进行了初步讨论,对本文选用的方剂剂型进行了分析,对于中医症型对于骨质疏松症的中医症状评分做出了思考,最后提出本次观察存在的不足,对中医特色治疗骨质疏松症结果做出肯定。
[Abstract]:Objective: to observe the clinical effect of Yougui Pill plus decoction in treating osteoporosis, and to compare it with Zhenmushengu capsule in the treatment of osteoporosis, so as to elicit the mechanism of the treatment of osteoporosis by adding and reducing prescription of Yougui Pill. To explore the shortcomings and deficiencies of traditional Chinese medicine (TCM) in the treatment of osteoporosis, so as to enrich the clinical use of Osteoporosis. Methods: under the guidance of TCM syndrome differentiation and holistic concept, the clinical efficacy of Zhenmu Shengu capsule (JMC) in patients with osteoporosis due to deficiency of liver and kidney was studied. 60 patients who met the inclusion criteria were randomly divided into treatment group (30 patients) and control group (30 patients). The treatment group was given the right Gui Pill plus or minus prescription, the patient took 1 pill twice a day. Morning and evening warm water delivery clothes. The control group was given Zhenmu Shengu capsule 3 times a day. Take it continuously for two months and observe the patient's condition. Before the beginning of the observation test, the clinical symptoms and bone mineral density of each patient were recorded in detail, and the cure rate of the patients and the rebound of TCM symptoms after half a year treatment were counted. Results: the recorded data showed that there was no significant difference between the two groups after statistical analysis of clinical symptoms and bone mineral density fluctuation, which indicated that the two groups were comparable. The treatment group and the control group were treated with Yougui Pill and Zhenjiangshengu capsule for 3 months. The clinical symptoms and bone mineral density of each patient were recorded in detail again. The results showed that the changes of clinical symptoms and bone mineral density were larger and statistically significant after the observation of the test. Conclusion: according to the analysis of data, it can be inferred that Yougui Pill plus subtraction prescription and Zhenzhen Mushengu capsule have certain curative effect on the patients with deficiency of liver and kidney fracture and osteoporosis, and the treatment group is superior to the control group. However, both drugs have a certain rate of loss of visits, and both of them are patients with severe osteoporosis. It can be inferred that for the treatment of severe osteoporosis patients, the curative effect of Yougui Pill or Zhenmushengu capsule alone is not good, and the treatment result of severe osteoporosis should be combined with other treatment schemes. In the part of discussion, the drug mechanism of Yougui Pill in treating osteoporosis was discussed, the formulation of prescription was analyzed, and the TCM symptom score of TCM syndrome type for osteoporosis was considered. Finally, the shortcomings of this observation are pointed out, and the results of TCM characteristic treatment of osteoporosis are confirmed.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259

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