25羟维生素D与妊娠期高血压疾病的相关性研究

发布时间：2018-07-21 20:04

【摘要】：目的探讨血清25羟维生素D水平与妊娠期高血压疾病之间的相关性。方法采用电化学发光免疫分析法检测163名妊娠期高血压疾病患者(其中A组妊娠期高血压56人、B组轻度子痫前期62人和C组重度子痫前期45人)及86名正常妊娠孕妇(对照组)在不同孕周时的血清25羟维生素D水平,分析25羟维生素D与妊娠期高血压疾病的相关性。结果在妊娠12~18周、30~36周时,对照组25羟维生素D水平为(19.2±3.14)和(23.5±2.15)ng/m L;A组为(18.6±2.35)和(20.3±2.13)ng/m L;B组为(12.4±0.34)和(17.5±1.46)ng/m L;C组为(9.6±1.45)和(11.1±2.26)ng/m L。A组与对照组的25羟维生素D水平差异无统计学意义(P0.05),B、C两组25羟维生素D水平均明显低于对照组(P0.01)。结论 25羟维生素D的下降与子痫前期的发病相关,且早于子痫前期临床症状的出现,有预测子痫前期发生的作用。
[Abstract]:Objective to investigate the correlation between serum 25 hydroxyvitamin D level and hypertensive disorder complicating pregnancy. Methods Electrochemiluminescence immunoassay (ECL) was used to detect 163 patients with hypertensive disorder complicating pregnancy (including 56 patients with hypertension complicating pregnancy and 62 patients with mild preeclampsia in group B and 45 patients with severe preeclampsia in group C) and 86 normal pregnancies. Serum 25 hydroxyvitamin D levels in pregnant women (control group) at different gestational weeks, To analyze the correlation between 25 hydroxyvitamin D and hypertensive disorder complicating pregnancy. Results at the 12th week of gestation, 30 weeks after gestation, The levels of 25 hydroxyvitamin D in the control group were (19.2 卤3.14) and (23.5 卤2.15) ng/m / L, respectively (18.6 卤2.35) and (20.3 卤2.13) ng/m / L (12.4 卤0.34) and (17.5 卤1.46) ng/m / L, respectively, which were significantly lower than those in the control group (9.6 卤1.45) and (11.1 卤2.26) ng/m L.A (P 0.05). Conclusion the decrease of 25 hydroxyvitamin D is associated with preeclampsia and is earlier than that of preeclampsia, which can predict the occurrence of preeclampsia.
【作者单位】：温州市中西医结合医院(温州市儿童医院);温州医科大学附属第一医院;
【分类号】：R714.246

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