渗透树脂、含氟制剂及GC护牙素治疗正畸早期釉质脱矿的比较研究
发布时间：2018-07-24 10:06
【摘要】：目的:正畸过程中普遍存在釉质脱矿现象,釉质脱矿不仅造成釉质白斑,影响美观,而且随脱矿加重会形成早期龋。多种治疗制剂已被应用于临床,近年来也有大量相关研究,但研究对象多局限于两种制剂、缺乏对不同原理制剂的系统比较;研究内容多集中于治疗效果,对作用的时效性、持续性等特点的研究较少。研究对象和内容的局限性,使各种制剂间可比性下降,影响了对临床治疗的参考价值。因此,本实验选取了不同作用原理的常见有效制剂进行比较,并选取三个时间点,对渗透树脂、含氟制剂、GC护牙素治疗效果进行定性及定量检测,将不同制剂作用时效性、持续性及治疗效果进行了对比,旨在为临床治疗提供参考依据。材料与方法:1.材料准备:收集50颗前磨牙随机均匀分组,设置A组为对照组,B、C、D、E为实验组。2.建立脱矿模型:样品浸于人工脱矿液中,37 ℃,2周,脱矿液每日更换。3.治疗制剂处理:A组人工唾液处理,B组ClinproTM White Varnish处理,C组ClinproTM XT Varnish处理,D组GC护牙素处理,E组Icon渗透树脂处理。均置入人工唾液中6周,每日更换人工唾液。4.肉眼观察脱矿前后及治疗前后釉质表面颜色和平滑度变化。5.治疗2周末、4周末、6周末利用显微硬度计测定表面显微硬度,利用SPSS 17软件对显微硬度值进行统计对比。6.治疗6周后,利用扫描电镜(SU8010)观察釉质表面形态。结果:1.肉眼观察:(1)釉质脱矿后各组均呈现明显的白垩色外观、表面粗糙;(2)不同制剂处理后,各组差异显著,A组釉质表面色泽和粗糙度轻微改善,再矿化效果D组B组C组,E组处理后,釉质脱矿即刻改善,效果最明显。2.显微硬度值比较:(1)组间对比表明,处理2周后,除B、C组无统计学差异外(p0.05),其余各组差异显著(p0.01),治疗4、6周,各组间均具有显著差异(p0.01);(2)组内对比表明,A组第2、第4周间无统计学差异(p0.05),其余各组差异显著(p0.01),B组第4、6周无差异(p0.05),其余差异显著(p0.01),C、D组三个时间点均差异显著(p0.01),E组三个时间点均无统计学差异(p0.05)。3.扫描电镜观察:(1)A组表面不平滑,少量沉积物分布,脱矿间隙较大,釉质末端有溶解和破坏;(2)B组表面不平滑,以小颗粒沉积物为主,脱矿间隙不明显,釉质末端被沉积颗粒覆盖;(3)C组表面不平滑,沉积颗粒较小,脱矿间隙不明显,少量釉质末端可见;(4)D组表面较平滑,沉积颗粒较小,无明显脱矿间隙,釉质末端较完整;(5)E组釉质表面较平滑,无明显脱矿间隙,可见紧密排列的杆状树脂突。结论:1.作用的时效性:人工唾液最缓慢;含氟试剂前两周作用缓慢,四周后明显;GC护牙素早期即作用明显;Icon渗透树脂可即刻恢复釉质表面色泽和形态;治疗时效性为Icon渗透树脂GC护牙素ClinproTM XT VarnishClinproTM White Varnish人工唾液。2.作用的持续性:人工唾液再矿化作用随时间轻度增加;4周后ClinproTM White Varnish再矿化作用不明显;ClinproTM XT Varnish和GC护牙素再矿化作用持续时间长;Icon渗透树脂即刻完成治疗且效果稳定。3.最终治疗效果:结合肉眼观察、扫描电镜、显微硬度,各种制剂治疗早期釉质脱矿的效果依次为Icon渗透树脂GC护牙素ClinproTM XT VarnishClinproTM White Varnish人工唾液。
[Abstract]:Objective: enamel demineralization is common in orthodontic process. Enamel demineralization not only causes enamel leukoplakia, but also causes early decayed enamel. A variety of treatment preparations have been applied to clinical and many related studies have been applied in recent years, but the research object is limited to two kinds of preparations and lack of systematic comparison of different principles. The research content concentrates on the effect of treatment, the research on the effect of timeliness, persistence and other characteristics is less. The limitations of the research object and content make the comparability between various preparations decrease and affect the reference value of the clinical treatment. Therefore, this experiment selects the common effective preparations of different action pros and choose three times. The effect of osmotic resin, fluorine containing preparation and GC in the treatment of dentin was measured qualitatively and quantitatively. The effect of aging, persistence and treatment of different preparations were compared. The purpose was to provide reference basis for clinical treatment. Materials and methods: 1. material preparation: collect 50 premolars randomly and evenly group, set A group as control group, B, C, D, E The demineralization model was established for the experimental group.2.: the samples were immersed in the artificial demineralization solution, 37 and 2 weeks, and the demineralized solution was changed daily for the treatment of.3. treatment preparations: group A artificial saliva treatment, group B ClinproTM White Varnish treatment, C group ClinproTM XT Varnish treatment, D group dentin treatment and infiltration resin treatment. They were all placed in artificial saliva for 6 weeks, daily replacement. Artificial saliva.4. eyes before and after demineralization and before and after demineralization and before and after the treatment of enamel surface color and skid change.5. treatment 2 weekend, 4 weekend, the 6 weekend, the use of microhardness tester to determine the surface microhardness, the use of SPSS 17 software to compare the microhardness value of the microhardness values for 6 weeks after the.6. treatment, using scanning electron microscopy (SU8010) to observe the surface morphology of enamel. Results: 1 Naked eye observation: (1) after enamel demineralization, all groups showed obvious Cretaceous appearance and rough surface; (2) after the treatment of the different preparations, the differences were significant, the color and roughness of the enamel surface of group A was slightly improved, the remineralization effect of group D B group C, after E group treatment, the enamel demineralization immediately improved, the effect of the most obvious.2. microhardness was compared: (1) comparison among groups The results showed that after 2 weeks of treatment, there was no statistical difference in group C except B (P0.05), and the difference between the other groups was significant (P0.01), and there was significant difference between each group (P0.01). (2) there was no statistical difference between second and fourth weeks in group A (P0.05), and there was a significant difference between the other groups (P0.01), and there was no difference in 4,6 week (P0.05) in the B group. The rest of the difference was significant. The three time points of group D were significantly different (P0.01), and there was no statistical difference between the three time points of group E (P0.05).3. scanning electron microscope: (1) the surface of A group was not smooth, a small amount of sediment was distributed, the demineralization gap was larger, the end of the enamel was dissolved and destroyed; (2) the surface of the B group was not smooth, and the deposit gap was not obvious and the end of the enamel was sunk. (3) the surface of the C group is not smooth, the deposition particles are smaller, the demineralization gap is not obvious, the end of a small amount of enamel is visible; (4) the surface of the group of D is smooth, the deposition particles are smaller, there is no clear demineralization gap, the end of the enamel is more complete; (5) the enamel surface of group E is smooth, there is no obvious demineralization gap, and the close arrangement of rod form resin process can be seen. Conclusion: 1. effect. Timeliness: artificial saliva is the slowest; fluorine containing reagent is slow in two weeks and obvious after four weeks; GC amidin is obvious in the early stage; Icon permeation resin can instantly restore the color and shape of enamel surface; the therapeutic timeliness is the continuity of the role of Icon osmosis resin GC amidin ClinproTM XT VarnishClinproTM White Varnish artificial saliva.2.. The effect of the remineralization of the saliva was slightly increased with time, and the remineralization of ClinproTM White Varnish was not obvious after 4 weeks; the remineralization of ClinproTM XT Varnish and GC was prolonged for a long time; Icon osmosis resin immediately completed the treatment and the effect was stable.3. final treatment effect: combined with meat eye observation, scanning electron microscope, microhardness, and the treatment of various preparations. The effect of early enamel demineralization was Icon osmotic resin GC, dentin ClinproTM XT VarnishClinproTM White Varnish artificial saliva.
【学位授予单位】：山东大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R783.5
本文编号：2141030
[Abstract]:Objective: enamel demineralization is common in orthodontic process. Enamel demineralization not only causes enamel leukoplakia, but also causes early decayed enamel. A variety of treatment preparations have been applied to clinical and many related studies have been applied in recent years, but the research object is limited to two kinds of preparations and lack of systematic comparison of different principles. The research content concentrates on the effect of treatment, the research on the effect of timeliness, persistence and other characteristics is less. The limitations of the research object and content make the comparability between various preparations decrease and affect the reference value of the clinical treatment. Therefore, this experiment selects the common effective preparations of different action pros and choose three times. The effect of osmotic resin, fluorine containing preparation and GC in the treatment of dentin was measured qualitatively and quantitatively. The effect of aging, persistence and treatment of different preparations were compared. The purpose was to provide reference basis for clinical treatment. Materials and methods: 1. material preparation: collect 50 premolars randomly and evenly group, set A group as control group, B, C, D, E The demineralization model was established for the experimental group.2.: the samples were immersed in the artificial demineralization solution, 37 and 2 weeks, and the demineralized solution was changed daily for the treatment of.3. treatment preparations: group A artificial saliva treatment, group B ClinproTM White Varnish treatment, C group ClinproTM XT Varnish treatment, D group dentin treatment and infiltration resin treatment. They were all placed in artificial saliva for 6 weeks, daily replacement. Artificial saliva.4. eyes before and after demineralization and before and after demineralization and before and after the treatment of enamel surface color and skid change.5. treatment 2 weekend, 4 weekend, the 6 weekend, the use of microhardness tester to determine the surface microhardness, the use of SPSS 17 software to compare the microhardness value of the microhardness values for 6 weeks after the.6. treatment, using scanning electron microscopy (SU8010) to observe the surface morphology of enamel. Results: 1 Naked eye observation: (1) after enamel demineralization, all groups showed obvious Cretaceous appearance and rough surface; (2) after the treatment of the different preparations, the differences were significant, the color and roughness of the enamel surface of group A was slightly improved, the remineralization effect of group D B group C, after E group treatment, the enamel demineralization immediately improved, the effect of the most obvious.2. microhardness was compared: (1) comparison among groups The results showed that after 2 weeks of treatment, there was no statistical difference in group C except B (P0.05), and the difference between the other groups was significant (P0.01), and there was significant difference between each group (P0.01). (2) there was no statistical difference between second and fourth weeks in group A (P0.05), and there was a significant difference between the other groups (P0.01), and there was no difference in 4,6 week (P0.05) in the B group. The rest of the difference was significant. The three time points of group D were significantly different (P0.01), and there was no statistical difference between the three time points of group E (P0.05).3. scanning electron microscope: (1) the surface of A group was not smooth, a small amount of sediment was distributed, the demineralization gap was larger, the end of the enamel was dissolved and destroyed; (2) the surface of the B group was not smooth, and the deposit gap was not obvious and the end of the enamel was sunk. (3) the surface of the C group is not smooth, the deposition particles are smaller, the demineralization gap is not obvious, the end of a small amount of enamel is visible; (4) the surface of the group of D is smooth, the deposition particles are smaller, there is no clear demineralization gap, the end of the enamel is more complete; (5) the enamel surface of group E is smooth, there is no obvious demineralization gap, and the close arrangement of rod form resin process can be seen. Conclusion: 1. effect. Timeliness: artificial saliva is the slowest; fluorine containing reagent is slow in two weeks and obvious after four weeks; GC amidin is obvious in the early stage; Icon permeation resin can instantly restore the color and shape of enamel surface; the therapeutic timeliness is the continuity of the role of Icon osmosis resin GC amidin ClinproTM XT VarnishClinproTM White Varnish artificial saliva.2.. The effect of the remineralization of the saliva was slightly increased with time, and the remineralization of ClinproTM White Varnish was not obvious after 4 weeks; the remineralization of ClinproTM XT Varnish and GC was prolonged for a long time; Icon osmosis resin immediately completed the treatment and the effect was stable.3. final treatment effect: combined with meat eye observation, scanning electron microscope, microhardness, and the treatment of various preparations. The effect of early enamel demineralization was Icon osmotic resin GC, dentin ClinproTM XT VarnishClinproTM White Varnish artificial saliva.
【学位授予单位】：山东大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R783.5
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