选择性绿激光汽化术与前列腺电切术对治疗良性前列腺增生症临床疗效的Meta分析

发布时间：2018-07-26 15:42

【摘要】：目的:通过收集以往相关文献,比较选择性绿激光汽化术(Photoselective vaporizationof the prostate,PVP)与前列腺电切术(Transurethral resection of prostate,TURP)对治疗良性前列腺增生症(Benign prostate hyperpkia,BPH)的临床疗效。方法:按照Cochrane协作网工作手册的要求制定检索策略,计算机检索:英文检索:PubMed、Embase、Cochrane Library、Web of Scince等数据库;中文检索:万方、维普、CNKI、CBMdisc等数据库,收集比较PVP及TURP治疗BPH的随机对照试验文献,并由两位系统评价员分别进行独立文献筛查、质量评价和资料提取,并交叉核对。使用统计软件RevMan5.3完成Meta分析。结果:最终纳入12篇文献,均为随机对照试验,总样本量1451例,PVP组732例,TURP组719例。Meta分析结果:PVP组比TURP组住院时间短[(P0.01),95%CI为(-3.63~-2.13)],术后留置导尿管时间短[(P0.01),95%CI为(-2.42~-1.21)],术后血红蛋白下降少[(P0.0 1),95%CI为(-1.36~-0.71)],术后输血发生率低[(RR=0.1,P0.001),95%CI为(0.04~-0.26)];术后随访6个月及12个月IPSS及Qmax差异均无统计学意义(均P0.05)。结论:选择性绿激光汽化术与前列腺电切术均能显著改善轻、中度前列腺增生患者的症状,具有相似的临床疗效。但与TURP相比,PVP操作更安全,术后留置导尿时间及住院时间更短;远期疗效方面PVP与TURP无显著差异。
[Abstract]:Objective: to compare the clinical efficacy of selective green laser vaporization (Photoselective vaporizationof the prostata) and (Transurethral resection of prostata (TURP) in the treatment of benign prostatic hyperplasia (BPH). Methods: according to the requirements of the work manual of Cochrane Cooperative Network, the search strategy was formulated. The computer search was conducted to search the database of the Web of Scince, such as the Web of Scince, and so on, and the Chinese retrieval was done with the following databases: Wanfang, Vipric, CBMdisc, etc. The randomized controlled trials of PVP and TURP for BPH were collected and compared, and the independent literature screening, quality evaluation, data extraction and cross-check were carried out by two systematic evaluators. Use statistical software RevMan5.3 to complete Meta analysis. Results: twelve articles were included, all of which were randomized controlled trials. The results of Meta-analysis showed that the hospitalization time of TURP group was shorter than that of TURP group [(P0.01) 95 CI was (-3.63) -2.13], the duration of postoperative catheter was short [(-2.42 ~ 1.21) CI was (-2.42) -1.21], the hemoglobin decreased less [(P0.01) 95 CI was (-1.36 卤-0.71)], the incidence of blood transfusion was low [(RRR0.1P0.001) 95 CI was (0.04- 0.26)]; There was no significant difference in IPSS and Qmax after 6 months and 12 months follow-up (P 0.05). Conclusion: selective green laser vaporization and electroprostatectomy can significantly improve the symptoms of mild and moderate benign prostatic hyperplasia and have similar clinical efficacy. Compared with TURP, the operation of PVP was safer, the time of indwelling catheterization and hospital stay was shorter, and there was no significant difference between PVP and TURP in the long term effect.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R699.8

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