乌鲁木齐部分地区碘营养状态与甲状腺癌的相关性研究

发布时间：2018-08-13 19:10

【摘要】：目的:探讨乌鲁木齐部分地区碘营养状态与甲状腺癌的关系。方法:选取2014年3月-2014年12月在新疆医科大学第一附属医院血管甲状腺外科行手术治疗并经病理证实的甲状腺良性结节患者158例为甲状腺良性结节组、甲状腺癌患者156例为甲状腺癌组,及同期在新疆医科大学第二附属医院体检中心行甲状腺超声提示甲状腺形态正常者301例为甲状腺形态正常组。记录三组一般资料、尿碘及血清甲状腺功能、甲状腺自身抗体表达水平,并进行比较分析。甲状腺癌危险因素分析采用多因素Logistic回归分析。结果:三组性别、年龄间差异有统计学意义(P0.05);而民族间差异无统计学意义(P0.05)。三组血清总三碘甲腺原氨酸(TT _3)、总甲状腺素(TT4)、促甲状腺激素(TSH)、甲状腺球蛋白抗体(TgAb)、甲状腺过氧化物酶抗体(TPOAb)水平间差异均有统计学意义(P0.05)。615例受试者尿碘中位数为[261.50(221.50)]μg/L,其中甲状腺形态正常组为[257.60(169.35)]μg/L,甲状腺良性结节组为[261.05(263.42)]μg/L,甲状腺癌组为[297.90(374.40)]μg/L,三组间差异有统计学意义(P0.05);其中甲状腺癌组与甲状腺良性结节组、甲状腺形态正常组比较,甲状腺良性结节组与甲状腺形态正常组比较,差异均有统计学意义(P0.05)。多因素Logistic回归分析结果显示,碘过量、女性、血清TgAb异常是甲状腺癌的危险因素(P0.05)。结论:乌鲁木齐地区人群碘缺乏状态已纠正,并处于超适宜量水平,碘过量、女性、血清TgAb异常是甲状腺癌的危险因素,建议该地区人群饮食上控制含碘食物及碘盐的摄入。
[Abstract]:Objective: to investigate the relationship between iodine nutritional status and thyroid carcinoma in Urumqi. Methods: from March 2014 to December 2014, 158 patients with benign thyroid nodule were selected as thyroid benign nodule group, who were treated surgically and pathologically in the first affiliated Hospital of Xinjiang Medical University. 156 patients with thyroid cancer were diagnosed as thyroid carcinoma, and 301 patients with normal thyroid morphology were examined by thyroid ultrasound in the physical examination center of the second affiliated Hospital of Xinjiang Medical University. The general data of the three groups, urine iodine, serum thyroid function and thyroid autoantibody expression were recorded and compared. Multivariate Logistic regression analysis was used to analyze the risk factors of thyroid cancer. Results: there were significant differences in sex and age among the three groups (P0.05), but there was no significant difference among ethnic groups (P0.05). The levels of serum total triiodothyronine (TT _ 3), total thyroxine (TT4), thyroid stimulating hormone (TSH),) thyroglobulin antibody (TgAb),) thyroid peroxidase antibody (TPOAb) were significantly different among the three groups (P0.05). [261.50 (221.50)] 渭 g / L, including [257.60 (169.35) 渭 g / L, [261.05 (263.42) 渭 g / L, [297.90 (374.40)] 渭 g / L, in thyroid benign nodule group and thyroid carcinoma group, respectively (P0.05). The comparison of normal thyroid morphology group, thyroid benign nodule group and thyroid shape normal group, the difference was statistically significant (P0.05). Multivariate Logistic regression analysis showed that iodine overdose, female and serum TgAb abnormality were risk factors of thyroid carcinoma (P0.05). Conclusion: iodine deficiency status has been corrected in Urumqi area, and it is at the level of overdose. Iodine excess, female and serum TgAb abnormality are the risk factors of thyroid cancer. It is suggested that the intake of iodized food and iodized salt should be controlled in the diet of the population in Urumqi.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R736.1

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