冠心病阿司匹林抵抗临床危险因素及中医证素分布研究

发布时间：2019-07-04 14:50

【摘要】：目的:分析冠心病阿司匹林抵抗(Aspirinresistance,AR)的患病率、相关危险因素及中医证素分布情况,为防治阿司匹林抵抗提供依据。方法:选取服用阿司匹林(1OOmg/晚)至少4周的经造影证实的冠心病患者100例,平均年龄68.95±8.91岁。根据花生四烯酸AA(1mmol/L)诱导的血小板聚集实验结果分为三组:血小板聚集率≥80%为阿司匹林抵抗,聚集率≥50%且80%为阿司匹林半抵抗(Aspirin semiresistance,ASR),聚集率50%为阿司匹林敏感(Aspirin sensitive,AS),并以文献资料研究、专家咨询为基础,对每位患者的中医证素类型(主要为气虚、痰浊、血瘀、气滞、阳虚、阴虚、寒凝7种)进行判定,比较三组的相关危险因素及中医证素分布。结果:冠心病患者中阿司匹林抵抗12例,阿司匹林抵抗组空腹血糖、肌酐、冠脉病变血管数及严重病变数较其他组高(P0.05),餐后2h胰岛素水平较其他组低(P0.05)。三组中医证素分布比较无统计学差异(P0.05)。二元回归分析显示空腹血糖水平是阿司匹林抵抗的危险因素。结论:冠心病阿司匹林抵抗具有较高发生率,空腹血糖水平与阿司匹林抵抗具有密切相关性,阿司匹林抵抗组虚证主要证素为气虚、阴虚,实证主要证素为血瘀、痰浊,阿司匹林敏感性不影响中医证素分布情况。
[Abstract]:Objective: to analyze the prevalence, risk factors and distribution of TCM syndromes of aspirin resistance (Aspirinresistance,AR) in coronary heart disease (CAD), so as to provide evidence for the prevention and treatment of aspirin resistance. Methods: 100 patients with coronary heart disease confirmed by radiography with aspirin (1OOmg/) for at least 4 weeks were selected, with an average age of 68.95 卤8.91 years. According to the results of platelet aggregation induced by arachidonic acid AA (1mmol/L), the platelet aggregation rate 鈮，

本文编号：2509998