水稻tree1增变表型的分子遗传学研究

发布时间：2018-05-11 10:49

本文选题：水稻 + 异时性　；参考：《中国农业科学院》2017年博士后论文

【摘要】：生物体内DNA损伤错配修复系统是保证生物体内细胞基因组稳定和忠实性传递一条重要途径。人类中遗传性直肠癌研究表明损伤修复系统中MSH2基因突变会导致组织中细胞出现增变表型,但不断增变表型产生的分子机理并不清楚。水稻tree1是植物特有的MSH7基因突变而致的增变表型,表现为水稻植株分蘖增多,株高变矮,生长时期转换推迟等。分子遗传学分析发现tree1增变表型很大一部分与miR156b/c基因高转录水平紧密相关,而导致miR156b/c基因错误高转录表达推测可能是表观遗传基因OsLHP1突变造成的。
[Abstract]:In vivo DNA damage mismatch repair system is an important way to ensure the stability and faithfulness of cell genome. Studies on human hereditary rectal cancer show that mutations of MSH2 gene in the damage repair system may lead to phenotypic changes in tissues, but the molecular mechanism of increasing phenotypes is not clear. Rice tree1 is an increasing phenotype caused by plant specific MSH7 gene mutation, which is characterized by more tillers, shorter plant height and delayed growth period. Molecular genetic analysis showed that a large part of the phenotype of tree1 was closely related to the high transcriptional level of miR156b/c gene, and the mis-expression of miR156b/c gene might be caused by the OsLHP1 mutation of epigenetic gene.
【学位授予单位】：中国农业科学院
【学位级别】：博士后
【学位授予年份】：2017
【分类号】：S511

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