面向信息化的中药提取过程监控系统研究

发布时间：2018-05-30 08:02

本文选题：中药提取 + 监控系统　；参考：《天津科技大学》2015年硕士论文

【摘要】：中药提取过程是中药生产过程中的关键环节,药材的提取效果直接关系着中药产品的质量。随着2010版GMP的实施,对各个制药企业在生产设备、软件系统、人员与现场管理等方面都提出了新的更高的要求。但由于中药成分复杂以及对中药产品质量控制的新要求,研究中药提取过程参数与产品质量之间的关系仍然是中药提取过程监控系统研究的难点。由于直接指标无法在线测量,通过实现生产过程的数据信息化,研究过程参数与质量指标的关系,建立中药提取过程参数与产品质量指标之间的关系模型,间接获得产品质量指标,是实现质量指标智能检测的有效途径。而且,通过所建立的关系模型,还可控制相应的过程参数,最终实现质量控制。因此,研究面向信息化的中药提取过程监控系统,就要建立网络化开放型的数据库,实现生产过程数据的开放与共享,研究建立的过程参数与质量指标的关系,指导控制生产过程,最终达到质量控制的目的；构建网络化的监控系统,实现数据的信息化与资源共享,满足新版的GMP提出的要求,为中药企业的综合管控一体化建设奠定基础。本课题以中药水提取过程作为研究对象,通过了解中药提取和浓缩的工艺流程,分析了影响生产过程的关键参数,确定了系统检测与控制方案；构建了面向信息化的中药提取过程监控系统框架。同时,进行PLC控制系统设计和监控软件的设计开发,具有生产过程的实时和远程监控,用户管理、报警记录和报表管理等功能,实现生产过程数据的查询与存储以及过程操作的可追溯。系统的监控管理层与控制层之间采用工业以太网通讯协议进行通讯,为实现企业数据共享提供网络接口。在此基础上,研究了数据库技术和信息处理技术,实现了外部SQL数据库的构建和数据的开放,存储中药生产过程所涉及的生产过程类数据；同时对中药提取过程参数与提取率之间的关系进行了探讨性研究。并根据统计控制理论,拟合了过程参数与提取率的回归方程。最后使用C#语言进行面向信息化的信息管理平台的设计与开发,实现对过程数据的分析。本系统易于操作,人机界面友好,运行稳定,满足GMP要求。
[Abstract]:The extraction process of traditional Chinese medicine is a key link in the production of traditional Chinese medicine. The extraction effect of traditional Chinese medicine is directly related to the quality of traditional Chinese medicine products. With the implementation of GMP version 2010, new and higher requirements are put forward for each pharmaceutical enterprise in production equipment, software system, personnel and field management. However, due to the complexity of traditional Chinese medicine components and the new requirements for the quality control of traditional Chinese medicine products, the study of the relationship between the parameters of traditional Chinese medicine extraction process and the product quality is still a difficult point in the study of the monitoring system of the traditional Chinese medicine extraction process. Because the direct indexes can not be measured online, the relationship between the process parameters and the quality indexes is studied by realizing the data information of the production process, and the relationship model between the parameters of the traditional Chinese medicine extraction process and the product quality indexes is established. Indirectly obtaining product quality index is an effective way to realize intelligent detection of quality index. Furthermore, the corresponding process parameters can be controlled by the established relational model, and the quality control can be realized finally. Therefore, to study the information-oriented monitoring system of traditional Chinese medicine extraction process, it is necessary to establish a networked open database, to realize the opening and sharing of production process data, and to study the relationship between the established process parameters and the quality index. To guide and control the production process, to achieve the goal of quality control, to build a networked monitoring system, to realize the information and resource sharing of data, to meet the requirements of the new version of GMP, For the integrated management and control of Chinese medicine enterprises to lay the foundation for integration. This topic takes the traditional Chinese medicine water extraction process as the research object, through understanding the traditional Chinese medicine extraction and the concentration technological process, has analyzed the influence production process key parameter, has determined the system detection and the control plan; The framework of information-oriented monitoring system for traditional Chinese medicine extraction process is constructed. At the same time, PLC control system design and monitoring software design and development, with the production process of real-time and remote monitoring, user management, alarm records and report management, and other functions, Realize the query and storage of production process data and the traceability of procedure operation. The communication protocol of industrial Ethernet is adopted between the supervisory management and control layer of the system, which provides the network interface for the realization of enterprise data sharing. On this basis, the database technology and information processing technology are studied, the construction of external SQL database and the opening of data are realized, and the production process data related to the production process of traditional Chinese medicine are stored. At the same time, the relationship between extraction process parameters and extraction rate was studied. According to the statistical control theory, the regression equation between the process parameters and the extraction rate is fitted. Finally, the information management platform oriented to information is designed and developed with C # language to realize the analysis of process data. The system is easy to operate, friendly man-machine interface, stable operation, meet the requirements of GMP.
【学位授予单位】：天津科技大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：TP277

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