基于逆向工程的宽颈动脉瘤介入治疗的数值模拟研究
发布时间：2019-02-24 10:18
【摘要】：临床上对窄颈动脉瘤已经有了比较成熟的实践经验,但是对于相对比较复杂的宽颈动脉瘤临床经验比较少。单纯植入支架治疗有时候达不到理想的临床效果,这时就需要支架辅助栓塞技术进行治疗。为了研究不同宽颈动脉瘤的治疗方法,验证单纯支架植入和支架辅助栓塞技术各自在治疗这些复杂颅内动脉瘤的效果。文章选取了侧壁和分叉两种宽颈动脉瘤进行研究。探究这两种动脉瘤在介入治疗前后血流动力学各项参数变化并探究出现这种差异的影响因素。利用逆向工程技术提取出侧壁动脉瘤和分叉动脉瘤的三维实体模型。对两例宽颈动脉瘤输入相同的入口血流速度(0.2m/s),通过有限元分析软件模拟分析其各自的血流动力学参数;对侧壁动脉瘤植入支架并设置相同的入口速度进行数值模拟分析,得出血流动力学参数,发现效果并不十分理想;然后在植入支架的基础上对动脉瘤内部进行栓塞,再次设置相同边界条件进行数值模拟分析并得出血流动力学参数。支架植入侧壁动脉瘤后其最大壁面剪切力由原来的50.17Pa变为32.72Pa,血流速度由最初的0.98m/s减小到0.59m/s,在一定程度上有所降低但是效果不太理想,支架辅助栓塞之后最大壁面剪切力变为10.45Pa,速度下降至0.32m/s,效果显著,说明支架辅助栓塞治疗侧壁动脉瘤有较好的效果。最后对分叉动脉瘤植入Y型支架进行数值模拟分析,和上述设置同样的边界条件进行模拟,得出植入支架后的各项血流动力学参数。分叉动脉瘤在Y型支架植入后最大壁面剪切力由原来的197.8Pa下降至67.9Pa,最大速度也由原来的0.58m/s下降至0.21m/s,下降程度明显说明单纯植入Y型支架对于治疗该类分叉动脉瘤就有较好的疗效。
[Abstract]:Clinical experience of narrow carotid aneurysm has been more mature, but for relatively complex wide carotid aneurysm clinical experience is relatively small. Stent implantation alone sometimes fails to achieve satisfactory clinical results. Stent-assisted embolization is required. In order to study the treatment methods of different wide carotid aneurysms, the effects of stenting alone and stent-assisted embolization in the treatment of these complex intracranial aneurysms were verified. Two types of wide carotid aneurysms, lateral wall and bifurcation, were selected for study. To explore the changes of hemodynamic parameters before and after interventional therapy and to explore the factors that influence the difference between the two types of aneurysms. Three-dimensional solid models of lateral aneurysms and bifurcation aneurysms were extracted by reverse engineering. Two patients with wide carotid aneurysms were given the same inlet blood flow velocity (0.2m/s) and their hemodynamic parameters were simulated by finite element analysis software. Through numerical simulation and analysis of stenting and setting the same inlet velocity of lateral aneurysm, the hemodynamic parameters were obtained, and the results were not very satisfactory. Then the internal aneurysm was embolized on the basis of stent implantation, and the same boundary conditions were set again for numerical simulation and the hemodynamic parameters were obtained. The maximum wall shear force of stent implanted into lateral aneurysm changed from the original 50.17Pa to 32.72 Pa. the velocity of blood flow decreased from the initial 0.98m/s to 0.59 m / s, to some extent, but the effect was not very good. After stent-assisted embolization, the maximum wall shear force changed to 10.45 Paand the velocity decreased to 0.32 m / s, which indicated that stent-assisted embolization had a better effect on lateral aneurysms. Finally, the numerical simulation of Y-stent implantation in bifurcation aneurysms was carried out, and the same boundary conditions as above were used to simulate the hemodynamic parameters of the implanted stents. The maximum wall shear force decreased from the original 197.8Pa to 67.9 Pa, and the maximum velocity also decreased from the original 0.58m/s to 0.21 m / s after Y stent implantation. The degree of decline obviously indicates that Y-stent implantation alone is effective in the treatment of this type of bifurcation aneurysm.
【学位授予单位】：新疆大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R654.3;TP391.7
本文编号：2429456
[Abstract]:Clinical experience of narrow carotid aneurysm has been more mature, but for relatively complex wide carotid aneurysm clinical experience is relatively small. Stent implantation alone sometimes fails to achieve satisfactory clinical results. Stent-assisted embolization is required. In order to study the treatment methods of different wide carotid aneurysms, the effects of stenting alone and stent-assisted embolization in the treatment of these complex intracranial aneurysms were verified. Two types of wide carotid aneurysms, lateral wall and bifurcation, were selected for study. To explore the changes of hemodynamic parameters before and after interventional therapy and to explore the factors that influence the difference between the two types of aneurysms. Three-dimensional solid models of lateral aneurysms and bifurcation aneurysms were extracted by reverse engineering. Two patients with wide carotid aneurysms were given the same inlet blood flow velocity (0.2m/s) and their hemodynamic parameters were simulated by finite element analysis software. Through numerical simulation and analysis of stenting and setting the same inlet velocity of lateral aneurysm, the hemodynamic parameters were obtained, and the results were not very satisfactory. Then the internal aneurysm was embolized on the basis of stent implantation, and the same boundary conditions were set again for numerical simulation and the hemodynamic parameters were obtained. The maximum wall shear force of stent implanted into lateral aneurysm changed from the original 50.17Pa to 32.72 Pa. the velocity of blood flow decreased from the initial 0.98m/s to 0.59 m / s, to some extent, but the effect was not very good. After stent-assisted embolization, the maximum wall shear force changed to 10.45 Paand the velocity decreased to 0.32 m / s, which indicated that stent-assisted embolization had a better effect on lateral aneurysms. Finally, the numerical simulation of Y-stent implantation in bifurcation aneurysms was carried out, and the same boundary conditions as above were used to simulate the hemodynamic parameters of the implanted stents. The maximum wall shear force decreased from the original 197.8Pa to 67.9 Pa, and the maximum velocity also decreased from the original 0.58m/s to 0.21 m / s after Y stent implantation. The degree of decline obviously indicates that Y-stent implantation alone is effective in the treatment of this type of bifurcation aneurysm.
【学位授予单位】：新疆大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R654.3;TP391.7
【参考文献】
相关期刊论文 前10条
1 余永铭;;颅内宽颈动脉瘤血管内栓塞技术的现状与进展[J];微创医学;2015年03期
2 陈节;胡再虎;於永;崔明;;双微导管技术栓塞宽颈动脉瘤[J];安徽医学;2014年01期
3 刘明;刘肖;康红艳;邓小燕;;主动脉处的血流动力学特性及其生理意义[J];医用生物力学;2012年05期
4 孙安强;邓小燕;;冠状动脉支架血流动力学中的几个问题[J];生物物理学报;2011年08期
5 付文宇;孟宪龙;顾兆勇;乔爱科;;基于CT图像的胸主动脉瘤模型构建及分析[J];北京工业大学学报;2011年05期
6 黄俊;周正东;戴耀东;葛中远;张召长;;腹主动脉瘤的流固耦合分析方法研究[J];现代生物医学进展;2009年02期
7 宋江湖;陈国定;任延平;;考虑流固耦合作用的主动脉弓血液流动分析[J];中国生物医学工程学报;2008年03期
8 梁栋科;杨大智;;不同设计心血管支架的血流动力学分析[J];生物医学工程学杂志;2006年06期
9 赵丛海,杨新健,张金男,张晓龙,丁光宏,吴中学;一种经酶处理新型动脉瘤动物模型的建立[J];中华实验外科杂志;2005年07期
10 薛松,张密林,景小燕;药物支架的研究进展[J];应用科技;2004年01期
相关硕士学位论文 前1条
1 赵一博;弹性动脉局部狭窄血管内血流的ALE有限元分析[D];南华大学;2011年
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