[Abstract] Objective : To investigate the dexmedetomidine anesthesia for the prevention of postoperative delirium in elderly patients the clinical effect . Methods: 2011.06-2012.06 to our hospital for elective abdominal surgery intravenous anesthesia with endotracheal intubation of 100 patients , all patients were elderly, aged 60 and above ; randomly divided into observation group and control group, n = 50 cases ; The patients given before induction of general anesthesia Right dexmedetomidine 0.8ug/kg, continuous infusion for 10 minutes, followed by intubation . maintenance dose after intubation by 0.4ug/kg/h, stopping 30 minutes before surgery , control patients intravenous normal saline , the same sequence intubation ; observed in patients with sleep score, delirium incidence and duration of hospitalization .Results: The statistical observation group were sleep score was (2.18 ± 0.7), two cases of delirium in patients , the rate was 4.00% ; patients with sleep score of the control group (3.71 ± 0.9), 9 patients with delirium , the rate was 18.00 % ; two groups of patients with sleep scores and compare the incidence of delirium were statistically significant (P <0.05). Conclusion: elderly surgical patients with severe , continuous intravenous infusion of dexmedetomidine will be able to improve sleep quality , prevention of postoperative delirium in elderly patients the incidence of anesthesia , effectively reduce the incidence of delirium in patients suitable for promoting the use of clinical surgery .
Key words Dexmedetomidine ; Epidural anesthesia ; Delirium
谵妄是一种以兴奋性增高为主的高级神经中枢急性活动失调状态，临床上主要表现为意识模糊、定向力丧失、感觉错乱（幻觉、错觉）、躁动不安、语言杂乱等[1]。谵妄可发生于急性感染的发热期间，也可见于某些药物中毒、代谢循环障碍以及中枢神经系统疾病。在临床外科，老年重症患者的谵妄发生率比较高，有关研究显示危重患者发生率在35％—80％。 右美托嘧啶是一种高选择性的α2肾上腺素能受体激动药，，具有镇静、抗焦虑、镇痛等作用，适合用于ICU全身麻醉的手术患者气管插管和机械通气时的镇静。我院为探讨该药对预防老年患者全麻术后发生谵妄的临床效果而开展了此次研究，现报道如下：
1资料与方法
2结果
3讨论
参考文献
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174856
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