复旦大学发育生物学研究所

郑煜芳 博士

教授

电话: 021-65643718

E-mail: zhengyf@fudan.edu.cn

1993年进入清华大学生物科学与技术系，1999年获学士学位,1999年获理学硕士学位。1999年8月赴美国康奈尔大学医学院生理、生物物理和分子医学系，于2004年获博士学位。同年获美国耶鲁大学的Endowed Postdoctoral Fellowship，从事博士后研究。2007年起获聘为复旦大学副教授，硕导。2013年8月兼职复旦大学发育生物学研究所PI。2016年3月起任复旦大学附属妇产科医院生殖发育研究院副教授PI，2017年12月起任教授，PI。曾获得上海市浦江人才计划，复旦大学卓学人才计划等奖项。近五年承担的重要项目有国家自然基金委应急项目1项，上海市科委重点项目1项；参与基金委重点项目1项，参与973计划课题1项，863课题1项。

在在大脑皮层发育、神经干细胞分化和出生缺陷分子遗传机制等研究方向积累了较丰富的研究经验，，并取得了具有一定影响力的成果。实验室的研究方向为研究胚胎发育异常导致的：1）大脑神经干细胞发育及发育障碍相关疾病；2）神经管畸形和先心病的遗传分子和病理机制。

2015年 复旦大学 三八红旗手

2012年 复旦大学卓学计划

2012年 复旦大学生命科学学院 复星奖教金个人奖

2010,2012-2014年 复星医药奖教金“个人奖”四次

2010年 复旦大学生命科学学院 复星奖教金个人奖

2008年 上海市浦江人才计划，2010年结题获评优秀

1. Shi Z, Yang X, Li B, Chen S, Yang L, Chen L, Zhang T, Wang H, Zheng Y*. Novel mutation of LRP6 identified in Chinese Han population links canonical WNT signaling to neural tube defects. Birth Defects Res A 2017 Sep 29. doi: 10.1002/bdr2.1122.

2. Qiao X#, Liu Y#, Li P, Chen Z, Li H, Yang X, Finnell RH, Yang Z, Zhang T, Qiao B, Zheng Y*, Wang H*. Genetic analysis of rare coding mutations in CELSR1-3 in Chinese Congenital Heart and Neural Tube Defects. Clin Sci (Lond). 2016 Oct 18. 130(24): 2329-40, doi: 10.1042/CS20160686

3. Wang B#, Zheng Y#, Shi H, Du X, Zhang Y, Wei B, Luo M, Wang H, Wu X, Hua X, Sun M*, Xu X*. Zfp462 deficiency causes anxiety-like behaviors with excessive self-grooming in mice. Genes Brain Behav. 2016 Sep 13. doi: 10.1111/gbb.12339.

4. Liu B, Ma A, Zhang F, Wang Y, Li Z, Li Q, Xu Z, Zheng Y*. MAZ mediates the cross-talk between CT-1 and NOTCH1 signaling during gliogenesis. Scientific Reports, 2016 Feb 12;6:21534. doi: 10.1038/srep21534.

5. Li P, Li H, Zheng Y, Qiao B, Duan W, Huang L, Liu W, Wang H*. Variants in the Regulatory Region of WNT5A Reduced Risk of Cardiac Conotruncal Malformations in the Chinese Population. Scientific Reports, 2015 Aug 17;5:13120.

6. Li Q, Zhang Z, Li Z, Zhou M, Liu B, Pan L, Ma Z, Zheng Y*. ADAM17 is critical for multipolar exit and radial migration of neuronal intermediate progenitor cells in mice cerebral cortex. PLoS ONE 2013 June 3; 8(6): e65703.

7. Ma Z, Li Q, Zhang Z, Zheng Y*. A Disintegrin and Metalloprotease 10 in neuronal maturation and gliogenesis during cortex development. Neural Regen Res. 2013 8(1):24-30.

8. Peng C, Ye J, Yan S, Kong S, Shen Y, Li C, Li Q, Zheng Y, Deng K, Xu T, Tao W. Ablation of vacuole protein sorting 18 (vps18) gene leads to neurodegeneration and impaired neuronal migration by disrupting multiple vesicle transport pathways to lysosomes. J Biol Chem. 2012 Sep 21; 287(39):32861-73.

9. Li J, Liu B, Gao X, Ma Z, CaoSong T, Mei Y, Zheng Y*. Overexpression of Sigma-1 receptor inhibits ADAM10 and ADAM17 mediated shedding in vitro. Protein Cell 2012 Feb; 3(2): 153-9.

10. Zhang WB, Cheng MJ, Huang YT, Jiang W, Cong Q, Zheng YF*, Xu CJ*. A study in vitro on differentiation of bone marrow mesenchymal stem cells into endometrial epithelial cells in mice. Eur J Obstet Gynecol Reprod Biol. 2012 Feb; 160(2): 185-90.

11. Jin K, Xue C, Qian J, Zhu Y, Wu X, Yang Z, Yonezawa T, M. James C. Crabbe, Cao Y, Hasegawa M, Zhong Y*, Zheng Y*. Why does the giant panda eat bamboo? A comparative analysis of appetite-reward-related genes among mammals. PLoS ONE 2011; 6(7):e22602.

12. Zhang LP#, Zheng Y#, Li D, Zhong Y. Self-organizing Map of Gene Regulatory Networks for Cell Phenotypes during Reprogramming. Comput Biol Chem. 2011 Aug 10; 35(4):211-7.

13. Zhang X, Chen J, Zheng Y, Gao X, Kang Y, Zhang J, Cheng M, Sun H, Xu C* Follicle stimulating hormone peptide can facilitate paclitaxel nanoparticles target to ovarian carcinoma in vivo. Cancer Res 2009 Aug 15; 69(16):6506-14.

14. Kang Y, Zhang X, Jiang W, Wu C, Chen C, Gu J, Zheng Y*, and Xu C* The piggyBac transposon is an integrating non-viral gene transfer vector that enhances the efficiency of GDEPT. Cell Biol Int, 2009 Apr; 33: 509-515.

15. Ly A, Nikolaev A, Suresh G, Zheng Y, Tessier-Lavigne M, Stein E. DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1. Cell, 2008 Jun 27; 133: 1241-1254.

16. Zheng Y, Peschon J, Saftig P, Hartmann D, Blobel CP. Evaluation of the contribution of different ADAMs to TNFα shedding and of the function of the TNFα ectodomain in ensuring selective stimulated shedding by the TNFα convertase (TACE/ADAM17). J. Biol Chem. 2004 Oct 8; 279(41): 42898-906.

17. Zheng Y, Schlondorff J, Blobel CP. Evidence for regulation of the tumor necrosis factor alpha-convertase (TACE) by protein-tyrosine phosphatase PTPH1. J Biol Chem. 2002 Nov 8; 277(45): 42463-70.